STRINGSTRING
ZNF143 ZNF143 EREG EREG BMPR1A BMPR1A IL18 IL18 BMP4 BMP4 CALCRL CALCRL AIF1 AIF1 JUN JUN FOXJ2 FOXJ2 CYBA CYBA CX3CL1 CX3CL1 SMPD5 SMPD5 LDLRAP1 LDLRAP1 PDGFB PDGFB EDN1 EDN1 HBEGF HBEGF HES5 HES5 AKT1 AKT1 IGFBP5 IGFBP5 STAT1 STAT1 TNF TNF MAP3K5 MAP3K5 ITGA2 ITGA2 RPS6KB1 RPS6KB1 MMP2 MMP2 IL6 IL6 FGFR2 FGFR2 S1PR1 S1PR1 ID2 ID2 MFN2 MFN2 MNAT1 MNAT1 DDR2 DDR2 TLR4 TLR4 CCN4 CCN4 TGFB1 TGFB1 IL6R IL6R NPY5R NPY5R SRC SRC SMPD3 SMPD3 IRAK1 IRAK1 PTGS2 PTGS2 MEF2D MEF2D MMP9 MMP9 ALOX12 ALOX12 HTR1B HTR1B ERN1 ERN1 DNMT1 DNMT1 NOTCH3 NOTCH3 ADAMTS1 ADAMTS1 IGF1R IGF1R PDGFRB PDGFRB NR4A3 NR4A3 TERT TERT FRS2 FRS2 TGFBR2 TGFBR2 FGF9 FGF9 ELANE ELANE HMOX1 HMOX1 XBP1 XBP1 NF1 NF1 THBS1 THBS1 GJA1 GJA1 PIK3CA PIK3CA NOX1 NOX1 ITGB3 ITGB3 P2RY6 P2RY6 FOXP1 FOXP1 SERPINF2 SERPINF2 IGF1 IGF1 IRAK4 IRAK4 PHB PHB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZNF143Selenocysteine tRNA gene transcription-activating factor. (638 aa)
EREGProepiregulin. (169 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (472 aa)
AIF1Allograft inflammatory factor 1; Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation (By similarity). (147 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (334 aa)
FOXJ2Forkhead box J2. (586 aa)
CYBAUncharacterized protein. (210 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (407 aa)
SMPD5Uncharacterized protein. (381 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (320 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (265 aa)
EDN1Preproendothelin-1. (211 aa)
HBEGFEGF-like domain-containing protein. (214 aa)
HES5Uncharacterized protein. (166 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IGFBP5Insulin-like growth factor-binding protein 5. (272 aa)
STAT1Signal transducer and activator of transcription. (802 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1483 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1180 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (550 aa)
MMP272 kDa type IV collagenase isoform a preproprotein. (660 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (266 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
S1PR1Sphingosine 1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
ID2Inhibitor of DNA binding 2. (203 aa)
MFN2Mitofusin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (896 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
CCN4WNT1-inducible-signaling pathway protein 1. (367 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IL6RInterleukin 6 receptor. (536 aa)
NPY5RG_PROTEIN_RECEP_F1_2 domain-containing protein. (455 aa)
SRCTyrosine-protein kinase. (644 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (725 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
MEF2DMyocyte-specific enhancer factor 2D. (521 aa)
MMP9Uncharacterized protein. (707 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
HTR1B5-hydroxytryptamine receptor 1B. (390 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (978 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1717 aa)
NOTCH3Notch receptor 3. (2321 aa)
ADAMTS1A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein. (967 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (717 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1130 aa)
FRS2Fibroblast growth factor receptor substrate 2. (550 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (263 aa)
HMOX1Heme oxygenase 1. (288 aa)
XBP1X-box binding protein 1. (376 aa)
NF1Neurofibromin 1. (2867 aa)
THBS1Thrombospondin 1. (1170 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NOX1NADPH oxidase 1. (564 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (741 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
FOXP1Fork-head domain-containing protein. (695 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (594 aa)
IGF1Insulin like growth factor 1. (208 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
PHBProhibitin. (272 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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