(40 nodes) Embryonic cranial skeleton morphogenesis network (Macaca mulatta)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IRX5	Iroquois homeobox 5. (694 aa)
	RDH10	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
	TBX1	T-box transcription factor 1. (496 aa)
	TFAP2A	Transcription factor AP-2 alpha. (445 aa)
	PRRX1	Uncharacterized protein. (245 aa)
	GLI3	GLI family zinc finger 3. (1580 aa)
	DLX2	Distal-less homeobox 2. (344 aa)
	RUNX2	RUNX family transcription factor 2. (647 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
	HOXA2	Homeobox A2. (374 aa)
	ALX3	ALX homeobox 3. (343 aa)
	FOXC2	Forkhead box C2. (471 aa)
	SIX1	SIX homeobox 1. (284 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	MED12	Mediator complex subunit 12. (2178 aa)
	FGFR2	Fibroblast growth factor receptor. (841 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	PAX5	Paired box 5. (407 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	SLC39A1	Uncharacterized protein. (386 aa)
	WDR19	WD_REPEATS_REGION domain-containing protein. (1348 aa)
	SIX2	SIX homeobox 2. (292 aa)
	NODAL	Nodal growth differentiation factor. (347 aa)
	NIPBL	Nipped-B protein. (2804 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2565 aa)
	GRHL2	Grainyhead like transcription factor 2. (625 aa)
	MTHFD1L	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (976 aa)
	CHST11	Carbohydrate sulfotransferase. (352 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	MMP14	Matrix metalloproteinase-14 preproprotein. (582 aa)
	MMP16	Matrix metallopeptidase 16. (607 aa)
	HOXA1	Homeobox protein Hox-1F. (335 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
	EIF4A3	Eukaryotic initiation factor 4A-III; Belongs to the DEAD box helicase family. (411 aa)
	TBX15	T-box transcription factor 15. (635 aa)
	TEAD4	TUB like protein 3; Belongs to the TUB family. (728 aa)
	IFT140	Intraflagellar transport 140. (1462 aa)
	SIX4	SIX homeobox 4. (772 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALX3	TBX15	ENSMMUP00000073205	ENSMMUP00000012127	ALX homeobox 3.	T-box transcription factor 15.	0.536
BMP4	DLX2	ENSMMUP00000077296	ENSMMUP00000068563	Bone morphogenetic protein 4.	Distal-less homeobox 2.	0.513
BMP4	FGF8	ENSMMUP00000077296	ENSMMUP00000020713	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.698
BMP4	FGFR2	ENSMMUP00000077296	ENSMMUP00000048184	Bone morphogenetic protein 4.	Fibroblast growth factor receptor.	0.509
BMP4	RUNX2	ENSMMUP00000077296	ENSMMUP00000070378	Bone morphogenetic protein 4.	RUNX family transcription factor 2.	0.678
BMP4	SMAD2	ENSMMUP00000077296	ENSMMUP00000045810	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.759
BMP4	SMAD3	ENSMMUP00000077296	ENSMMUP00000041841	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.651
BMP4	TFAP2A	ENSMMUP00000077296	ENSMMUP00000053446	Bone morphogenetic protein 4.	Transcription factor AP-2 alpha.	0.516
BMP4	TGFBR1	ENSMMUP00000077296	ENSMMUP00000051737	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.761
BMP4	TGFBR2	ENSMMUP00000077296	ENSMMUP00000013111	Bone morphogenetic protein 4.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.529
DLX2	BMP4	ENSMMUP00000068563	ENSMMUP00000077296	Distal-less homeobox 2.	Bone morphogenetic protein 4.	0.513
DLX2	FGF8	ENSMMUP00000068563	ENSMMUP00000020713	Distal-less homeobox 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.477
DLX2	IRX5	ENSMMUP00000068563	ENSMMUP00000022960	Distal-less homeobox 2.	Iroquois homeobox 5.	0.444
DLX2	RUNX2	ENSMMUP00000068563	ENSMMUP00000070378	Distal-less homeobox 2.	RUNX family transcription factor 2.	0.544
FGF8	BMP4	ENSMMUP00000020713	ENSMMUP00000077296	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.698
FGF8	DLX2	ENSMMUP00000020713	ENSMMUP00000068563	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Distal-less homeobox 2.	0.477
FGF8	FGFR2	ENSMMUP00000020713	ENSMMUP00000048184	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.999
FGF8	GLI3	ENSMMUP00000020713	ENSMMUP00000067447	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	GLI family zinc finger 3.	0.523
FGF8	TGFB3	ENSMMUP00000020713	ENSMMUP00000015831	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.444
FGFR2	BMP4	ENSMMUP00000048184	ENSMMUP00000077296	Fibroblast growth factor receptor.	Bone morphogenetic protein 4.	0.509