STRINGSTRING
PHOSPHO2 PHOSPHO2 ARID5B ARID5B IHH IHH HOXC11 HOXC11 COL1A1 COL1A1 SIX4 SIX4 FMN1 FMN1 SP5 SP5 SOX6 SOX6 PKD1 PKD1 THRA THRA IFT140 IFT140 COL11A2 COL11A2 BMP7 BMP7 COL11A1 COL11A1 TEAD4 TEAD4 MMP13 MMP13 IFITM5 IFITM5 PPARGC1B PPARGC1B NEUROG1 NEUROG1 DHRS3 DHRS3 COL13A1 COL13A1 FOXC1 FOXC1 NOG NOG COMP COMP WDR60 WDR60 SERPINH1 SERPINH1 HHIP HHIP MAPK14 MAPK14 COL27A1 COL27A1 EXT1 EXT1 BMPR2 BMPR2 TBX15 TBX15 EIF4A3 EIF4A3 TGFBR2 TGFBR2 SKI SKI INPPL1 INPPL1 INSIG1 INSIG1 FBN2 FBN2 COL2A1 COL2A1 ACAN ACAN FUZ FUZ MYF5 MYF5 FLVCR1 FLVCR1 CHSY1 CHSY1 TGFB3 TGFB3 FREM1 FREM1 CER1 CER1 RARA RARA RARG RARG HOXA1 HOXA1 BMP1 BMP1 PLEKHA1 PLEKHA1 MMP16 MMP16 MMP14 MMP14 LTF LTF OTOR OTOR FGF8 FGF8 MEF2D MEF2D UNCX UNCX CHST11 CHST11 IFT80 IFT80 IRX5 IRX5 TRIP11 TRIP11 WNT7A WNT7A SPEF2 SPEF2 ACVR2B ACVR2B FGF18 FGF18 SMPD3 SMPD3 MTHFD1L MTHFD1L FOXN3 FOXN3 FGFR3 FGFR3 CSRNP1 CSRNP1 RAB33B RAB33B HOXB8 HOXB8 GRHL2 GRHL2 SFRP4 SFRP4 SETD2 SETD2 BMP6 BMP6 NIPBL NIPBL OSR2 OSR2 HOXB1 HOXB1 FGFR1 FGFR1 NODAL NODAL PAPPA2 PAPPA2 LTBP3 LTBP3 HOXD8 HOXD8 TGFB1 TGFB1 SIX2 SIX2 SFRP1 SFRP1 WWOX WWOX PSEN1 PSEN1 TBXT TBXT PEX7 PEX7 WDR19 WDR19 ZEB1 ZEB1 LOC704750 LOC704750 ACTN3 ACTN3 LRP5 LRP5 DLG1 DLG1 P2RX7 P2RX7 TIPARP TIPARP THBS3 THBS3 SLC39A1 SLC39A1 HOXC9 HOXC9 SMAD3 SMAD3 GLG1 GLG1 HAS2 HAS2 MEF2C MEF2C PAX5 PAX5 ZMPSTE24 ZMPSTE24 MEGF8 MEGF8 HOXA4 HOXA4 CITED4 CITED4 HOXD10 HOXD10 WDR48 WDR48 SGPL1 SGPL1 ANXA6 ANXA6 DSCAML1 DSCAML1 CCN2 CCN2 HOXD9 HOXD9 SMAD2 SMAD2 COL3A1 COL3A1 MGP MGP FGFR2 FGFR2 RARB RARB BMPR1B BMPR1B ATF2 ATF2 RFLNA RFLNA MED12 MED12 ENSMMUP00000049472 ENSMMUP00000049472 CITED2 CITED2 RDH10 RDH10 MMP2 MMP2 TMEM107 TMEM107 SATB2 SATB2 TGFBR1 TGFBR1 SCX SCX TBX1 TBX1 EYA1 EYA1 TFAP2A TFAP2A SOX5 SOX5 NLE1 NLE1 HOXD11 HOXD11 ALPL ALPL SOX11 SOX11 TRPV4 TRPV4 WNT10B WNT10B SCUBE2 SCUBE2 OSR1 OSR1 RYK RYK PRRX1 PRRX1 ANKRD12 ANKRD12 TSKU TSKU BARX2 BARX2 CTNNB1 CTNNB1 HOXA11 HOXA11 SHOX2 SHOX2 ALX4 ALX4 ABCB6 ABCB6 RFLNB RFLNB MATN1 MATN1 ENSMMUP00000065317 ENSMMUP00000065317 HOXB5 HOXB5 PAX1 PAX1 FGR FGR TCF15 TCF15 HOXC4 HOXC4 GLI3 GLI3 ACP5 ACP5 DLX2 DLX2 NAB2 NAB2 FGF6 FGF6 HOXB9 HOXB9 TIFAB TIFAB HOXB7 HOXB7 HOXB4 HOXB4 RUNX2 RUNX2 WNT9B WNT9B NKX3-2 NKX3-2 SMPD5 SMPD5 HOXA5 HOXA5 HOXA2 HOXA2 HOXB2 HOXB2 HOXD4 HOXD4 IMPAD1 IMPAD1 HOXA3 HOXA3 PCGF2 PCGF2 SOX9 SOX9 GSC GSC ZFAND5 ZFAND5 ALX3 ALX3 HOXD3 HOXD3 HOXB6 HOXB6 PRKRA PRKRA DLX5 DLX5 FOXC2 FOXC2 NPPC NPPC HOXC8 HOXC8 HYAL2 HYAL2 AXIN2 AXIN2 CDX1 CDX1 PHOSPHO1 PHOSPHO1 SIX1 SIX1 BMP4 BMP4 MSX1 MSX1 ANKRD11 ANKRD11 RAB23 RAB23 ATG9B ATG9B TBX4 TBX4 MDFI MDFI FGF4 FGF4 TMEM119 TMEM119 ACCS ACCS NAB1 NAB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PHOSPHO2Pyridoxal phosphate phosphatase PHOSPHO2. (241 aa)
ARID5BAT-rich interaction domain 5B. (1205 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
HOXC11Homeobox C11. (304 aa)
COL1A1Collagen alpha-1(I) chain preproprotein. (1464 aa)
SIX4SIX homeobox 4. (772 aa)
FMN1Formin 1. (1425 aa)
SP5Sp5 transcription factor. (398 aa)
SOX6SRY-box 6. (828 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4298 aa)
THRAThyroid hormone receptor alpha. (486 aa)
IFT140Intraflagellar transport 140. (1462 aa)
COL11A2Collagen type XI alpha 2 chain. (1676 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
COL11A1Collagen alpha-1(XI) chain isoform A preproprotein. (1806 aa)
TEAD4TUB like protein 3; Belongs to the TUB family. (728 aa)
MMP13Matrix metallopeptidase 13. (471 aa)
IFITM5Interferon induced transmembrane protein 5. (132 aa)
PPARGC1BPPARG coactivator 1 beta. (1023 aa)
NEUROG1Neurogenin 1. (237 aa)
DHRS3Short-chain dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
COL13A1Collagen type XIII alpha 1 chain. (717 aa)
FOXC1Forkhead box C1. (551 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
WDR60WD repeat domain 60. (1067 aa)
SERPINH1Serpin H1; Belongs to the serpin family. (418 aa)
HHIPHedgehog-interacting protein. (700 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
COL27A1Collagen type XXVII alpha 1 chain. (1853 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
TBX15T-box transcription factor 15. (635 aa)
EIF4A3Eukaryotic initiation factor 4A-III; Belongs to the DEAD box helicase family. (411 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
SKISKI proto-oncogene. (730 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1315 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (277 aa)
FBN2Fibrillin 2. (2912 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
ACANAggrecan. (2266 aa)
FUZFuzzy planar cell polarity protein. (445 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
FLVCR1Feline leukemia virus subgroup C cellular receptor 1. (555 aa)
CHSY1Hexosyltransferase. (802 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
FREM1FRAS1 related extracellular matrix 1. (2177 aa)
CER1Cerberus-related protein. (267 aa)
RARARetinoic acid receptor alpha isoform 1. (462 aa)
RARGRetinoic acid receptor gamma. (454 aa)
HOXA1Homeobox protein Hox-1F. (335 aa)
BMP1Metalloendopeptidase. (986 aa)
PLEKHA1Pleckstrin homology domain-containing family A member 1 isoform 1. (404 aa)
MMP16Matrix metallopeptidase 16. (607 aa)
MMP14Matrix metalloproteinase-14 preproprotein. (582 aa)
LTFLactotransferrin; Belongs to the transferrin family. (747 aa)
OTOROtoraplin. (128 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
MEF2DMyocyte-specific enhancer factor 2D. (521 aa)
UNCXHomeobox domain-containing protein. (167 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
IFT80Intraflagellar transport protein 80 homolog isoform a. (777 aa)
IRX5Iroquois homeobox 5. (694 aa)
TRIP11Thyroid hormone receptor interactor 11. (1819 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
SPEF2Calponin-homology (CH) domain-containing protein. (1822 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
MTHFD1LMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (976 aa)
FOXN3Forkhead box N3. (519 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
CSRNP1CSRNP_N domain-containing protein. (644 aa)
RAB33BRas-related protein Rab-33B. (229 aa)
HOXB8Homeobox B8. (242 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
SFRP4Secreted frizzled-related protein 4; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling. Has phosphaturic effects by specifically inhibiting sodium- dependent phosphate uptake. (346 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2565 aa)
BMP6Bone morphogenetic protein 6. (511 aa)
NIPBLNipped-B protein. (2804 aa)
OSR2Odd-skipped related transciption factor 2. (276 aa)
HOXB1Homeobox protein Hox-B1; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures (By similarity); Belongs to the Antp homeobox family. Labial subfamily. (304 aa)
FGFR1Fibroblast growth factor receptor. (853 aa)
NODALNodal growth differentiation factor. (347 aa)
PAPPA2Pappalysin 2. (1790 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1185 aa)
HOXD8Homeobox D8. (292 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SIX2SIX homeobox 2. (292 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
WWOXWW domain containing oxidoreductase. (414 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa)
TBXTT-box transcription factor T. (430 aa)
PEX7Peroxisomal biogenesis factor 7. (323 aa)
WDR19WD_REPEATS_REGION domain-containing protein. (1348 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1126 aa)
LOC704750Cytochrome P450 26B1; Belongs to the cytochrome P450 family. (512 aa)
ACTN3Uncharacterized protein. (942 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1612 aa)
DLG1Disks large homolog 1 isoform 2; Belongs to the MAGUK family. (926 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (573 aa)
TIPARPUncharacterized protein. (657 aa)
THBS3Uncharacterized protein. (956 aa)
SLC39A1Uncharacterized protein. (386 aa)
HOXC9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (260 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
GLG1Golgi glycoprotein 1. (1212 aa)
HAS2Hyaluronan synthase 2. (552 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform 1. (473 aa)
PAX5Paired box 5. (407 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
MEGF8Multiple EGF like domains 8. (2789 aa)
HOXA4Homeobox A4. (320 aa)
CITED4Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4. (232 aa)
HOXD10Homeobox D10. (340 aa)
WDR48WD repeat domain 48. (745 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
ANXA6Annexin. (673 aa)
DSCAML1DS cell adhesion molecule like 1. (2113 aa)
CCN2Cellular communication network factor 2. (349 aa)
HOXD9Homeobox D9. (345 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
COL3A1Collagen alpha-1(III) chain preproprotein. (1466 aa)
MGPMatrix Gla protein; Associates with the organic matrix of bone and cartilage. (128 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
RARBRetinoic acid receptor beta. (448 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
RFLNAUncharacterized protein. (216 aa)
MED12Mediator complex subunit 12. (2178 aa)
ENSMMUP00000049472Uncharacterized protein. (370 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
MMP272 kDa type IV collagenase isoform a preproprotein. (660 aa)
TMEM107Transmembrane protein 107. (207 aa)
SATB2DNA-binding protein SATB. (732 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
SCXScleraxis bHLH transcription factor. (201 aa)
TBX1T-box transcription factor 1. (496 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
TFAP2ATranscription factor AP-2 alpha. (445 aa)
SOX5SRY-box 5. (827 aa)
NLE1Notchless protein homolog 1 isoform a. (485 aa)
HOXD11Homeobox D11. (338 aa)
ALPLAlkaline phosphatase. (524 aa)
SOX11Transcription factor SOX. (441 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (963 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
SCUBE2Signal peptide, CUB domain and EGF like domain containing 2. (1076 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
RYKReceptor like tyrosine kinase. (611 aa)
PRRX1Uncharacterized protein. (245 aa)
ANKRD12Ankyrin repeat domain 12. (2058 aa)
TSKUUncharacterized protein. (353 aa)
BARX2Homeobox domain-containing protein. (279 aa)
CTNNB1Catenin beta-1. (781 aa)
HOXA11Homeobox A11. (311 aa)
SHOX2Short stature homeobox 2. (355 aa)
ALX4ALX homeobox 4. (409 aa)
ABCB6Uncharacterized protein. (1464 aa)
RFLNBRefilin B. (216 aa)
MATN1Matrilin 1. (495 aa)
ENSMMUP00000065317Uncharacterized protein. (184 aa)
HOXB5Homeobox B5. (269 aa)
PAX1Paired box 1. (535 aa)
FGRTyrosine-protein kinase. (529 aa)
TCF15BHLH domain-containing protein. (197 aa)
HOXC4Homeobox protein Hox-3E. (264 aa)
GLI3GLI family zinc finger 3. (1580 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
DLX2Distal-less homeobox 2. (344 aa)
NAB2NGFI-A-binding protein 2. (525 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
HOXB9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (250 aa)
TIFABTIFA inhibitor. (204 aa)
HOXB7Homeobox B7. (217 aa)
HOXB4Homeobox B4. (251 aa)
RUNX2RUNX family transcription factor 2. (647 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
NKX3-2Homeobox domain-containing protein. (333 aa)
SMPD5Uncharacterized protein. (381 aa)
HOXA5Homeobox A5. (381 aa)
HOXA2Homeobox A2. (374 aa)
HOXB2Homeobox B2. (356 aa)
HOXD4Homeobox D4. (255 aa)
IMPAD1Inositol monophosphatase domain containing 1. (384 aa)
HOXA3Homeobox A3. (443 aa)
PCGF2Polycomb group RING finger protein 2. (344 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
GSCGoosecoid homeobox. (259 aa)
ZFAND5Zinc finger A20 domain-containing protein 2. (213 aa)
ALX3ALX homeobox 3. (343 aa)
HOXD3Homeobox D3. (432 aa)
HOXB6Homeobox B6. (224 aa)
PRKRAProtein activator of interferon induced protein kinase EIF2AK2. (308 aa)
DLX5Distal-less homeobox 5. (289 aa)
FOXC2Forkhead box C2. (471 aa)
NPPCC-type natriuretic peptide. (126 aa)
HOXC8Homeobox protein Hox-3A. (242 aa)
HYAL2Hyaluronidase. (473 aa)
AXIN2Axin 2. (862 aa)
CDX1Caudal type homeobox 1. (265 aa)
PHOSPHO1Phosphoethanolamine/phosphocholine phosphatase. (301 aa)
SIX1SIX homeobox 1. (284 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
ANKRD11Ankyrin repeat domain 11. (2624 aa)
RAB23Ras-related protein Rab-23. (237 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (922 aa)
TBX4Uncharacterized protein. (544 aa)
MDFIMyoD family inhibitor. (246 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
TMEM119Uncharacterized protein. (280 aa)
ACCSExostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (857 aa)
NAB1Uncharacterized protein. (498 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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