(20 nodes) Positive regulation of oligodendrocyte differentiation network (Macaca mulatta)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

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Your Input:
	MDK	Midkine. (143 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
	GSX2	GS homeobox 2. (304 aa)
	ACY3	Aspartoacylase-2. (319 aa)
	NKX6-1	NK6 homeobox 1. (366 aa)
	OLIG2	Oligodendrocyte transcription factor 2. (323 aa)
	TP73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (660 aa)
	DAG1	Dystroglycan preproprotein. (894 aa)
	PTPRZ1	Uncharacterized protein. (2319 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	PTN	Uncharacterized protein. (172 aa)
	TNFRSF1B	TNF receptor superfamily member 1B. (501 aa)
	ASPA	Uncharacterized protein. (329 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
	TENM4	Teneurin transmembrane protein 4. (2929 aa)
	NKX2-2	Homeobox domain-containing protein. (451 aa)
	NKX6-2	Homeobox protein Nkx-6.2. (277 aa)
	IL34	Uncharacterized protein. (364 aa)
	RHEB	Uncharacterized protein. (249 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GSX2	OLIG2	ENSMMUP00000057090	ENSMMUP00000023227	GS homeobox 2.	Oligodendrocyte transcription factor 2.	0.425
GSX2	SHH	ENSMMUP00000057090	ENSMMUP00000065431	GS homeobox 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.524
HDAC1	HDAC2	ENSMMUP00000013015	ENSMMUP00000057724	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.999
HDAC1	NKX2-2	ENSMMUP00000013015	ENSMMUP00000066573	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Homeobox domain-containing protein.	0.677
HDAC1	TP73	ENSMMUP00000013015	ENSMMUP00000021769	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.432
HDAC2	HDAC1	ENSMMUP00000057724	ENSMMUP00000013015	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.999
HDAC2	TP73	ENSMMUP00000057724	ENSMMUP00000021769	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.401
IL34	PTPRZ1	ENSMMUP00000065743	ENSMMUP00000016302	Uncharacterized protein.	Uncharacterized protein.	0.759
MDK	PTN	ENSMMUP00000059508	ENSMMUP00000080883	Midkine.	Uncharacterized protein.	0.708
MDK	PTPRZ1	ENSMMUP00000059508	ENSMMUP00000016302	Midkine.	Uncharacterized protein.	0.886
MTOR	RHEB	ENSMMUP00000073444	ENSMMUP00000065504	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.995
NKX2-2	HDAC1	ENSMMUP00000066573	ENSMMUP00000013015	Homeobox domain-containing protein.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.677
NKX2-2	NKX6-1	ENSMMUP00000066573	ENSMMUP00000027862	Homeobox domain-containing protein.	NK6 homeobox 1.	0.533
NKX2-2	NKX6-2	ENSMMUP00000066573	ENSMMUP00000066295	Homeobox domain-containing protein.	Homeobox protein Nkx-6.2.	0.521
NKX2-2	OLIG2	ENSMMUP00000066573	ENSMMUP00000023227	Homeobox domain-containing protein.	Oligodendrocyte transcription factor 2.	0.746
NKX2-2	SHH	ENSMMUP00000066573	ENSMMUP00000065431	Homeobox domain-containing protein.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.471
NKX6-1	NKX2-2	ENSMMUP00000027862	ENSMMUP00000066573	NK6 homeobox 1.	Homeobox domain-containing protein.	0.533
NKX6-2	NKX2-2	ENSMMUP00000066295	ENSMMUP00000066573	Homeobox protein Nkx-6.2.	Homeobox domain-containing protein.	0.521
OLIG2	GSX2	ENSMMUP00000023227	ENSMMUP00000057090	Oligodendrocyte transcription factor 2.	GS homeobox 2.	0.425
OLIG2	NKX2-2	ENSMMUP00000023227	ENSMMUP00000066573	Oligodendrocyte transcription factor 2.	Homeobox domain-containing protein.	0.746