STRINGSTRING
MYH11 MYH11 EDNRA EDNRA CACNA1G CACNA1G POU4F1 POU4F1 HNRNPU HNRNPU LMNA LMNA ADAMTS9 ADAMTS9 MSC MSC LRRC10 LRRC10 PROX1 PROX1 FHOD3 FHOD3 ZFPM2 ZFPM2 TENM4 TENM4 NKX2-5 NKX2-5 ZFPM1 ZFPM1 MTOR MTOR GATA6 GATA6 WNT5A WNT5A FOXC2 FOXC2 TNNC1 TNNC1 SGCG SGCG ASB2 ASB2 ENG ENG BMP4 BMP4 LRP2 LRP2 EGLN1 EGLN1 TBX3 TBX3 BMPR1A BMPR1A NPPB NPPB ZMPSTE24 ZMPSTE24 MAP2K4 MAP2K4 TNNI1 TNNI1 ACTN2 ACTN2 NOTCH2 NOTCH2 TREX1 TREX1 MYH7 MYH7 S1PR1 S1PR1 DIPK2A DIPK2A FGFR2 FGFR2 NDRG4 NDRG4 RARB RARB TGFBR1 TGFBR1 TBX2 TBX2 DCUN1D2 DCUN1D2 SAV1 SAV1 MEF2A MEF2A ADRA1A ADRA1A LRRC10B LRRC10B SLC9A1 SLC9A1 HEY1 HEY1 C10orf113 C10orf113 ENSMMUP00000057513 ENSMMUP00000057513 MYL2 MYL2 MAML1 MAML1 MEF2C MEF2C OBSL1 OBSL1 CAV3 CAV3 MYLK2 MYLK2 MED1 MED1 WNT2 WNT2 SORBS2 SORBS2 HEY2 HEY2 SMAD7 SMAD7 JARID2 JARID2 ISL1 ISL1 SHOX2 SHOX2 TGFB2 TGFB2 NRG1 NRG1 KDM6B KDM6B BMP2 BMP2 DLL4 DLL4 GJB6 GJB6 CSRP3 CSRP3 NPRL3 NPRL3 PKP2 PKP2 PPP1R13L PPP1R13L RYR2 RYR2 HEG1 HEG1 NRAP NRAP IRX3 IRX3 TGFBR3 TGFBR3 GJA5 GJA5 MYL7 MYL7 FOXH1 FOXH1 PRMT1 PRMT1 MYO18B MYO18B BMP7 BMP7 COL11A1 COL11A1 SGCD SGCD WNT3A WNT3A GJA1 GJA1 GJC1 GJC1 TAZ TAZ FOXC1 FOXC1 NOG NOG MYL10 MYL10 ANKRD1 ANKRD1 ALPK2 ALPK2 SGCZ SGCZ NPPA NPPA PTEN PTEN TTN TTN WT1 WT1 FGF9 FGF9 TSC1 TSC1 ALPK3 ALPK3 MESP1 MESP1 NEBL NEBL TBX18 TBX18 HAND1 HAND1 CXADR CXADR AKAP13 AKAP13 PDGFRB PDGFRB CHD7 CHD7 BMP5 BMP5 TBX5 TBX5 RARA RARA TBX20 TBX20 XIRP2 XIRP2 MYOCD MYOCD TNNT2 TNNT2 MAPK11 MAPK11 BVES BVES MYL3 MYL3 DSP DSP BMP10 BMP10 SLC8A1 SLC8A1 MYBPC3 MYBPC3 SCN5A SCN5A ARID2 ARID2 FHL2 FHL2 NOTCH1 NOTCH1 ZIC3 ZIC3 GATA5 GATA5 CBY1 CBY1 HOPX HOPX PTCD2 PTCD2 SMAD4 SMAD4 SMAD1 SMAD1 ACVR1 ACVR1 VWA5B2 VWA5B2 IFT20 IFT20 GATA4 GATA4 ALDH1A2 ALDH1A2 ATG5 ATG5 SIRT6 SIRT6 VWA5A VWA5A NKX2-6 NKX2-6 DSG2 DSG2 PDLIM5 PDLIM5 WNT8A WNT8A TGFB1 TGFB1 PLEC PLEC SRF SRF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYH11Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2139 aa)
EDNRAUncharacterized protein; Belongs to the G-protein coupled receptor 1 family. (427 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2377 aa)
POU4F1POU domain protein. (423 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (825 aa)
LMNAPrelamin-A/C isoform 1; Belongs to the intermediate filament family. (663 aa)
ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif 9. (1935 aa)
MSCMusculin. (206 aa)
LRRC10Leucine-rich repeat-containing protein 10. (279 aa)
PROX1Prospero homeobox protein 1. (737 aa)
FHOD3Uncharacterized protein. (1655 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1177 aa)
TENM4Teneurin transmembrane protein 4. (2929 aa)
NKX2-5NK2 homeobox 5. (324 aa)
ZFPM1Zinc finger protein, FOG family member 1. (1024 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
GATA6Transcription factor GATA-6. (595 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (462 aa)
FOXC2Forkhead box C2. (471 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (213 aa)
SGCGSarcoglycan gamma. (346 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (790 aa)
ENGEndoglin. (672 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
LRP2LDL receptor related protein 2. (4660 aa)
EGLN1Uncharacterized protein. (426 aa)
TBX3T-box transcription factor 3. (743 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NPPBNatriuretic peptide B. (160 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
TNNI1Uncharacterized protein. (187 aa)
ACTN2Actinin alpha 2. (894 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa)
TREX1Three prime repair exonuclease 1. (474 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2036 aa)
S1PR1Sphingosine 1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
DIPK2ADivergent protein kinase domain 2A. (458 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
NDRG4NDRG family member 4. (494 aa)
RARBRetinoic acid receptor beta. (448 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
TBX2T-box transcription factor 2. (712 aa)
DCUN1D2Defective in cullin neddylation 1 domain containing 2. (1866 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
MEF2AMyocyte-specific enhancer factor 2A isoform 2. (503 aa)
ADRA1AAdrenoceptor alpha 1A. (445 aa)
LRRC10BLeucine rich repeat containing 10B. (292 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
HEY1Hairy/enhancer-of-split related with YRPW motif protein 1 isoform a. (304 aa)
C10orf113Chromosome 10 open reading frame 113. (155 aa)
ENSMMUP00000057513Uncharacterized protein. (260 aa)
MYL2Myosin light chain 2. (166 aa)
MAML1Mastermind like transcriptional coactivator 1. (1014 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform 1. (473 aa)
OBSL1Obscurin like 1. (1896 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (196 aa)
MYLK2Myosin light chain kinase 2. (603 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
SORBS2Sorbin and SH3 domain containing 2. (1246 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
SMAD7Mothers against decapentaplegic homolog. (462 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1281 aa)
ISL1ISL LIM homeobox 1. (413 aa)
SHOX2Short stature homeobox 2. (355 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
NRG1Neuregulin 1. (700 aa)
KDM6BLysine demethylase 6B. (1677 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (713 aa)
GJB6Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (261 aa)
CSRP3Cysteine and glycine rich protein 3. (253 aa)
NPRL3Nitrogen permease regulator 3-like protein isoform 1. (569 aa)
PKP2Plakophilin 2. (790 aa)
PPP1R13LProtein phosphatase 1 regulatory subunit 13 like. (828 aa)
RYR2Ryanodine receptor 2. (4967 aa)
HEG1Heart development protein with EGF like domains 1. (1486 aa)
NRAPNebulin related anchoring protein. (1731 aa)
IRX3Iroquois homeobox 3. (501 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
MYL7Myosin light chain 7. (251 aa)
FOXH1Forkhead box H1. (352 aa)
PRMT1Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
MYO18BMyosin XVIIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2565 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
COL11A1Collagen alpha-1(XI) chain isoform A preproprotein. (1806 aa)
SGCDSarcoglycan delta. (290 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
GJC1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (396 aa)
TAZTafazzin; Some isoforms may be involved in cardiolipin metabolism; Belongs to the taffazin family. (292 aa)
FOXC1Forkhead box C1. (551 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
MYL10Myosin light chain 10. (226 aa)
ANKRD1Ankyrin repeat domain 1. (318 aa)
ALPK2Alpha kinase 2. (2158 aa)
SGCZSarcoglycan zeta. (312 aa)
NPPANatriuretic peptide A. (153 aa)
PTENUncharacterized protein. (589 aa)
TTNTitin. (32000 aa)
WT1WT1 transcription factor. (517 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
TSC1TSC complex subunit 1. (1164 aa)
ALPK3Uncharacterized protein. (1855 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (272 aa)
NEBLNebulette. (1028 aa)
TBX18T-box transcription factor 18. (556 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
CXADRCXADR Ig-like cell adhesion molecule. (361 aa)
AKAP13A-kinase anchoring protein 13. (2899 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
CHD7Chromodomain-helicase-DNA-binding protein 7. (2998 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
TBX5T-box transcription factor 5. (518 aa)
RARARetinoic acid receptor alpha isoform 1. (462 aa)
TBX20T-box transcription factor TBX20. (447 aa)
XIRP2Xin actin binding repeat containing 2. (3550 aa)
MYOCDMyocardin. (986 aa)
TNNT2Troponin T2, cardiac type. (302 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
BVESBlood vessel epicardial substance. (360 aa)
MYL3Myosin light chain 3. (254 aa)
DSPDesmoplakin. (2871 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
SLC8A1J domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
MYBPC3Myosin binding protein C, cardiac. (1274 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2017 aa)
ARID2AT-rich interaction domain 2. (1836 aa)
FHL2Four and a half LIM domains 2. (396 aa)
NOTCH1Notch receptor 1. (2556 aa)
ZIC3Zic family member 3. (466 aa)
GATA5GATA binding protein 5. (397 aa)
CBY1Chibby family member 1, beta catenin antagonist. (268 aa)
HOPXHOP homeobox. (109 aa)
PTCD2Pentatricopeptide repeat domain 2. (364 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
VWA5B2Von Willebrand factor A domain-containing protein 5B2. (1243 aa)
IFT20Intraflagellar transport protein 20-like protein. (158 aa)
GATA4GATA binding protein 4. (443 aa)
ALDH1A2Retinal dehydrogenase 2 isoform 1; Belongs to the aldehyde dehydrogenase family. (518 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (317 aa)
SIRT6NAD-dependent deacetylase sirtuin-6. (355 aa)
VWA5AVon Willebrand factor A domain containing 5A. (813 aa)
NKX2-6NK2 homeobox 6. (301 aa)
DSG2Desmoglein 2. (1115 aa)
PDLIM5PDZ and LIM domain 5. (686 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PLECPlectin. (4862 aa)
SRFSerum response factor. (508 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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