STRINGSTRING
SEMA3C SEMA3C IGFBP5 IGFBP5 HIF1A HIF1A MITF MITF F2R F2R EPAS1 EPAS1 HNF1A HNF1A FGF10 FGF10 IL7 IL7 LIF LIF MMP2 MMP2 SNX10 SNX10 NOTCH2 NOTCH2 THBS4 THBS4 MEF2C MEF2C AXL AXL TIMP1 TIMP1 NCDN NCDN IAPP IAPP ACVRL1 ACVRL1 IL23A IL23A PTH1R PTH1R LRP5 LRP5 LGR4 LGR4 NFKB1 NFKB1 EDNRA EDNRA TGFB1 TGFB1 LTBP3 LTBP3 TCIRG1 TCIRG1 CELA1 CELA1 CCDC154 CCDC154 NOS3 NOS3 SRC SRC RASSF2 RASSF2 ATG5 ATG5 CTHRC1 CTHRC1 PTK2B PTK2B ACVR2B ACVR2B TRAF6 TRAF6 JAG1 JAG1 TNFSF11 TNFSF11 DBH DBH CSPG4 CSPG4 FGF8 FGF8 HTR1B HTR1B RSPO3 RSPO3 MDM2 MDM2 CAV1 CAV1 FLNA FLNA LRRK1 LRRK1 P3H4 P3H4 ATP7A ATP7A CRB1 CRB1 SPP2 SPP2 TGFB3 TGFB3 CTNNB1 CTNNB1 CHD7 CHD7 TIE1 TIE1 BMPR2 BMPR2 EXT1 EXT1 TPP1 TPP1 UMOD UMOD VDR VDR TPH1 TPH1 FOXC1 FOXC1 GJA1 GJA1 BAX BAX WNT16 WNT16 ADRB2 ADRB2 IHH IHH PTN PTN EPHA2 EPHA2 AGTR2 AGTR2 ARG1 ARG1 EFNA2 EFNA2 FOXC2 FOXC2 LIPA LIPA HOXA3 HOXA3 NOL3 NOL3 CCR2 CCR2 ACP5 ACP5 ELF3 ELF3 BAK1 BAK1 BSX BSX GDF5 GDF5 DLL4 DLL4 LOC114675515 LOC114675515 RAB3D-2 RAB3D-2 LOC106998769 LOC106998769 PLG PLG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SEMA3CSemaphorin-3C; Belongs to the semaphorin family. (751 aa)
IGFBP5Insulin-like growth factor-binding protein 5. (272 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (826 aa)
MITFMicrophthalmia-associated transcription factor isoform 1. (520 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
EPAS1Endothelial PAS domain protein 1. (875 aa)
HNF1AHNF1 homeobox A. (657 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
IL7Uncharacterized protein. (184 aa)
LIFLIF interleukin 6 family cytokine. (206 aa)
MMP272 kDa type IV collagenase isoform a preproprotein. (660 aa)
SNX10Sorting nexin 10. (227 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa)
THBS4Thrombospondin 4. (987 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform 1. (473 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
TIMP1Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). (207 aa)
NCDNNeurochondrin isoform 1. (729 aa)
IAPPIslet amyloid polypeptide. (89 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
IL23AInterleukin-23 subunit alpha. (189 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (593 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1612 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4. (951 aa)
NFKB1Uncharacterized protein. (977 aa)
EDNRAUncharacterized protein; Belongs to the G-protein coupled receptor 1 family. (427 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1185 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (853 aa)
CELA1Chymotrypsin like elastase 1; Belongs to the peptidase S1 family. (258 aa)
CCDC154Coiled-coil domain containing 154. (535 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
SRCTyrosine-protein kinase. (644 aa)
RASSF2Ras association domain-containing protein 2. (326 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (317 aa)
CTHRC1Collagen triple helix repeat containing 1. (243 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
TRAF6TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
DBHDopamine beta-hydroxylase. (620 aa)
CSPG4Chondroitin sulfate proteoglycan 4. (2322 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
HTR1B5-hydroxytryptamine receptor 1B. (390 aa)
RSPO3R-spondin 3. (273 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
CAV1Caveolin 1. (303 aa)
FLNAFilamin-A isoform 2. (2647 aa)
LRRK1Leucine rich repeat kinase 1. (2015 aa)
P3H4Prolyl 3-hydroxylase family member 4 (non-enzymatic). (699 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
CRB1Crumbs cell polarity complex component 1. (1406 aa)
SPP2Secreted phosphoprotein 2. (242 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
CTNNB1Catenin beta-1. (781 aa)
CHD7Chromodomain-helicase-DNA-binding protein 7. (2998 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
TPP1Tripeptidyl peptidase 1. (572 aa)
UMODUromodulin. (641 aa)
VDRVitamin D receptor. (477 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
FOXC1Forkhead box C1. (551 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
BAXUncharacterized protein. (279 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily. (415 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
PTNUncharacterized protein. (172 aa)
EPHA2EPH receptor A2. (1033 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (365 aa)
ARG1Arginase. (322 aa)
EFNA2Ephrin A2; Belongs to the ephrin family. (213 aa)
FOXC2Forkhead box C2. (471 aa)
LIPALipase; Belongs to the AB hydrolase superfamily. Lipase family. (399 aa)
HOXA3Homeobox A3. (443 aa)
NOL3Nucleolar protein 3. (206 aa)
CCR2C-C chemokine receptor type 2; Key functional receptor for CCL2 but can also bind CCL7 and CCL12 (By similarity). Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (By similarity) Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B (By similarity). Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation (By similari [...] (360 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
ELF3E74 like ETS transcription factor 3. (371 aa)
BAK1Uncharacterized protein. (261 aa)
BSXBrain specific homeobox. (232 aa)
GDF5Growth differentiation factor 5. (499 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (713 aa)
LOC114675515Uncharacterized protein. (152 aa)
RAB3D-2Ras-related protein Rab-3D. (219 aa)
LOC106998769Uncharacterized protein. (158 aa)
PLGPlasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...] (810 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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