(63 nodes) Artery morphogenesis network (Macaca mulatta)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	PRDM1	PR/SET domain 1. (820 aa)
	ANGPTL3	Angiopoietin like 3. (476 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	TFAP2B	Transcription factor AP-2 beta. (504 aa)
	LRP2	LDL receptor related protein 2. (4660 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	ENG	Endoglin. (672 aa)
	FOXC2	Forkhead box C2. (471 aa)
	ZMIZ1	Zinc finger MIZ-type containing 1. (1075 aa)
	PROX1	Prospero homeobox protein 1. (737 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (713 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	SMAD7	Mothers against decapentaplegic homolog. (462 aa)
	FOXF1	Forkhead box F1. (432 aa)
	HEY2	Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
	EDN1	Preproendothelin-1. (211 aa)
	PRRX1	Uncharacterized protein. (245 aa)
	HEY1	Hairy/enhancer-of-split related with YRPW motif protein 1 isoform a. (304 aa)
	LRP1	LDL receptor related protein 1. (4561 aa)
	LDLR	Uncharacterized protein. (918 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
	TBX1	T-box transcription factor 1. (496 aa)
	TBX2	T-box transcription factor 2. (712 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
	APOE	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
	COL3A1	Collagen alpha-1(III) chain preproprotein. (1466 aa)
	CITED4	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4. (232 aa)
	STRA6	Stimulated by retinoic acid 6. (707 aa)
	ACVRL1	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
	ADAMTS9	ADAM metallopeptidase with thrombospondin type 1 motif 9. (1935 aa)
	EFEMP2	EGF containing fibulin extracellular matrix protein 2. (576 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	EDNRA	Uncharacterized protein; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	HAND2	BHLH domain-containing protein. (186 aa)
	SRF	Serum response factor. (508 aa)
	ADGRF5	Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1383 aa)
	SEC24B	SEC24 homolog B, COPII coat complex component. (1277 aa)
	HPGD	15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	NOTCH1	Notch receptor 1. (2556 aa)
	ARID2	AT-rich interaction domain 2. (1836 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	MYLK	Myosin light chain kinase. (1914 aa)
	SOX4	Transcription factor SOX. (467 aa)
	NOTCH3	Notch receptor 3. (2321 aa)
	HOXA13	Homeobox A13. (226 aa)
	MYOCD	Myocardin. (986 aa)
	FKBP10	Peptidylprolyl isomerase. (582 aa)
	HOXA1	Homeobox protein Hox-1F. (335 aa)
	CHD7	Chromodomain-helicase-DNA-binding protein 7. (2998 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (969 aa)
	APOB	Apolipoprotein B. (4555 aa)
	NF1	Neurofibromin 1. (2867 aa)
	COMP	Cartilage oligomeric matrix protein. (757 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	FOXC1	Forkhead box C1. (551 aa)
	FOXH1	Forkhead box H1. (352 aa)
	GJA5	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
	NPRL3	Nitrogen permease regulator 3-like protein isoform 1. (569 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVRL1	BMP4	ENSMMUP00000039646	ENSMMUP00000077296	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.770
ACVRL1	BMPR1A	ENSMMUP00000039646	ENSMMUP00000079770	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.461
ACVRL1	BMPR2	ENSMMUP00000039646	ENSMMUP00000011799	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.980
ACVRL1	ENG	ENSMMUP00000039646	ENSMMUP00000076624	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Endoglin.	0.939
ACVRL1	SMAD7	ENSMMUP00000039646	ENSMMUP00000063793	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.675
ACVRL1	TGFB2	ENSMMUP00000039646	ENSMMUP00000064264	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.555
ACVRL1	TGFBR1	ENSMMUP00000039646	ENSMMUP00000051737	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.417
ADAMTS9	PDGFRB	ENSMMUP00000039566	ENSMMUP00000015166	ADAM metallopeptidase with thrombospondin type 1 motif 9.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.474
ANGPTL3	APOB	ENSMMUP00000080274	ENSMMUP00000010112	Angiopoietin like 3.	Apolipoprotein B.	0.772
ANGPTL3	APOE	ENSMMUP00000080274	ENSMMUP00000048554	Angiopoietin like 3.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.550
APOB	ANGPTL3	ENSMMUP00000010112	ENSMMUP00000080274	Apolipoprotein B.	Angiopoietin like 3.	0.772
APOB	APOE	ENSMMUP00000010112	ENSMMUP00000048554	Apolipoprotein B.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.996
APOB	LDLR	ENSMMUP00000010112	ENSMMUP00000052634	Apolipoprotein B.	Uncharacterized protein.	0.959
APOB	LRP1	ENSMMUP00000010112	ENSMMUP00000053745	Apolipoprotein B.	LDL receptor related protein 1.	0.512
APOB	LRP2	ENSMMUP00000010112	ENSMMUP00000077987	Apolipoprotein B.	LDL receptor related protein 2.	0.762
APOE	ANGPTL3	ENSMMUP00000048554	ENSMMUP00000080274	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Angiopoietin like 3.	0.550
APOE	APOB	ENSMMUP00000048554	ENSMMUP00000010112	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Apolipoprotein B.	0.996
APOE	EDN1	ENSMMUP00000048554	ENSMMUP00000062615	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Preproendothelin-1.	0.453
APOE	LDLR	ENSMMUP00000048554	ENSMMUP00000052634	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Uncharacterized protein.	0.515
APOE	LRP1	ENSMMUP00000048554	ENSMMUP00000053745	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	LDL receptor related protein 1.	0.989