STRINGSTRING
NOLC1 NOLC1 MAPK3 MAPK3 TBX1 TBX1 TBX2 TBX2 LIF LIF KLHL12 KLHL12 SLC9A1 SLC9A1 SHC4 SHC4 PTPRC PTPRC HESX1 HESX1 MSI2 MSI2 SOX11 SOX11 HIF1A HIF1A OSR1 OSR1 PHF19 PHF19 EZH2 EZH2 KIT KIT CORO1C CORO1C MED1 MED1 EDN1 EDN1 CTNNB1 CTNNB1 ISL1 ISL1 TGFB2 TGFB2 NRG1 NRG1 EGK_08539 EGK_08539 LRP6 LRP6 FN1 FN1 EDNRB EDNRB RDH10 RDH10 CITED2 CITED2 GPM6A GPM6A SEMA3E SEMA3E EPCAM EPCAM HMGA2 HMGA2 FGFR2 FGFR2 ERCC2 ERCC2 SEMA7A SEMA7A OTUD5 OTUD5 ANXA6 ANXA6 CITED4 CITED4 ZFP36 ZFP36 ETV4 ETV4 MEF2C MEF2C JARID2 JARID2 FOXO4 FOXO4 F6UCW2_MACMU F6UCW2_MACMU SEMA3F SEMA3F ECE2 ECE2 SEMA4A SEMA4A TAPT1 TAPT1 SHH SHH SOX10 SOX10 NRTN NRTN ENSMMUP00000065918 ENSMMUP00000065918 ENSMMUP00000066500 ENSMMUP00000066500 DMRTA2 DMRTA2 SOX17 SOX17 PHOX2B PHOX2B PITX2 PITX2 SP7 SP7 ENSMMUP00000067976 ENSMMUP00000067976 ENSMMUP00000068054 ENSMMUP00000068054 WNT10A WNT10A SETD6 SETD6 ESR1 ESR1 SOX8 SOX8 TP63 TP63 ZNF281 ZNF281 NRP1 NRP1 CYP26C1 CYP26C1 RADIL RADIL EDNRA EDNRA HAND2 HAND2 SEMA6A SEMA6A SRF SRF TBXT TBXT SFRP1 SFRP1 SEMA4B SEMA4B SEMA6B SEMA6B PEF1 PEF1 METTL5 METTL5 WNT8A WNT8A SEMA3D SEMA3D SETD2 SETD2 WNT3 WNT3 SEMA5A SEMA5A SEMA3B SEMA3B NRP2 NRP2 ALDH1A2 ALDH1A2 PHACTR4 PHACTR4 GDNF GDNF SEMA3G SEMA3G ACVR1 ACVR1 WNT7A WNT7A SMAD4 SMAD4 JAG1 JAG1 ZIC3 ZIC3 NOTCH1 NOTCH1 REST REST MTF2 MTF2 SNAI2 SNAI2 SFRP2 SFRP2 RET RET CDH2 CDH2 EPOP EPOP MYOCD MYOCD FBXL17 FBXL17 LMBR1L LMBR1L UFL1 UFL1 MAPK1 MAPK1 SMO SMO RPS7 RPS7 SEMA3C SEMA3C CHD2 CHD2 HTR2B HTR2B SEMA4G SEMA4G SEMA5B SEMA5B PAX2 PAX2 MEOX1 MEOX1 CDK6 CDK6 TP53 TP53 EXT1 EXT1 SEMA4D SEMA4D MAPK14 MAPK14 SEMA6C SEMA6C SEMA4C SEMA4C GBX2 GBX2 NOG NOG FOXC1 FOXC1 SEMA4F SEMA4F NELFB NELFB KBTBD8 KBTBD8 BATF BATF HNF1B HNF1B SH2B3 SH2B3 XRCC5 XRCC5 FAM172A FAM172A ELL3 ELL3 ERBB4 ERBB4 SOX18 SOX18 BCL2 BCL2 HOXB4 HOXB4 ENSMMUP00000070232 ENSMMUP00000070232 RUNX2 RUNX2 FOXA1 FOXA1 PHF5A PHF5A HOXD4 HOXD4 EOMES EOMES SOX9 SOX9 GSC GSC EDN3 EDN3 PSMD11 PSMD11 GATA6 GATA6 FRZB FRZB CMC4 CMC4 FOXC2 FOXC2 MLLT3 MLLT3 ENSMMUP00000075843 ENSMMUP00000075843 TCOF1 TCOF1 OVOL2 OVOL2 MSX1 MSX1 EFNB1 EFNB1 ENSMMUP00000077734 ENSMMUP00000077734 PUM1 PUM1 KITLG KITLG CDX2 CDX2 TBX3 TBX3 PWWP2A PWWP2A BMPR1A BMPR1A ENSMMUP00000080573 ENSMMUP00000080573 SEMA3A SEMA3A FGF19 FGF19 ENSMMUP00000081054 ENSMMUP00000081054
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOLC1Nucleolar and coiled-body phosphoprotein 1. (702 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
TBX1T-box transcription factor 1. (496 aa)
TBX2T-box transcription factor 2. (712 aa)
LIFLIF interleukin 6 family cytokine. (206 aa)
KLHL12BTB domain-containing protein. (606 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
SHC4Src-like proteiny 2 domain-containing-transforming protein C4. (630 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1310 aa)
HESX1HESX homeobox 1. (185 aa)
MSI2Musashi RNA binding protein 2. (340 aa)
SOX11Transcription factor SOX. (441 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (826 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
PHF19PHD finger protein 19. (599 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (832 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (527 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
EDN1Preproendothelin-1. (211 aa)
CTNNB1Catenin beta-1. (781 aa)
ISL1ISL LIM homeobox 1. (413 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
NRG1Neuregulin 1. (700 aa)
EGK_08539Uncharacterized protein. (283 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
FN1Fibronectin isoform 1 preproprotein. (2477 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (527 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
GPM6ANeuronal membrane glycoprotein M6-a isoform 2. (278 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
EPCAMEpithelial cell adhesion molecule; May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity). Belongs to the EPCAM family. (314 aa)
HMGA2High mobility group AT-hook 2. (147 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
ERCC2TFIIH basal transcription factor complex helicase XPD subunit isoform 1. (760 aa)
SEMA7ASemaphorin-7A isoform 1 preproprotein; Belongs to the semaphorin family. (664 aa)
OTUD5OTU deubiquitinase 5. (566 aa)
ANXA6Annexin. (673 aa)
CITED4Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4. (232 aa)
ZFP36ZFP36 ring finger protein. (332 aa)
ETV4ETS variant 4. (684 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform 1. (473 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1281 aa)
FOXO4Fork head domain transcription factor AFX1. (505 aa)
F6UCW2_MACMU40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (785 aa)
ECE2EEF1AKMT4-ECE2 readthrough. (883 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (760 aa)
TAPT1Transmembrane anterior posterior transformation 1. (790 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
SOX10SRY-box transcription factor 10. (467 aa)
NRTNNeurturin preproprotein. (197 aa)
ENSMMUP00000065918Uncharacterized protein. (117 aa)
ENSMMUP00000066500Uncharacterized protein. (236 aa)
DMRTA2DMRT like family A2. (538 aa)
SOX17SRY-box transcription factor 17. (414 aa)
PHOX2BPaired like homeobox 2B. (314 aa)
PITX2Homeobox protein. (354 aa)
SP7Uncharacterized protein. (431 aa)
ENSMMUP00000067976Uncharacterized protein. (120 aa)
ENSMMUP00000068054Uncharacterized protein. (102 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
SETD6SET domain containing 6, protein lysine methyltransferase. (610 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
SOX8SRY-box transcription factor 8. (617 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
ZNF281Zinc finger protein 281. (809 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa)
RADILRap associating with DIL domain. (1071 aa)
EDNRAUncharacterized protein; Belongs to the G-protein coupled receptor 1 family. (427 aa)
HAND2BHLH domain-containing protein. (186 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1047 aa)
SRFSerum response factor. (508 aa)
TBXTT-box transcription factor T. (430 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (831 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (948 aa)
PEF1Uncharacterized protein. (283 aa)
METTL5MTS domain-containing protein. (209 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (778 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2565 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
SEMA5AUncharacterized protein. (1080 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (748 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (925 aa)
ALDH1A2Retinal dehydrogenase 2 isoform 1; Belongs to the aldehyde dehydrogenase family. (518 aa)
PHACTR4Phosphatase and actin regulator. (817 aa)
GDNFGlial cell derived neurotrophic factor. (342 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (782 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
ZIC3Zic family member 3. (466 aa)
NOTCH1Notch receptor 1. (2556 aa)
RESTRE1 silencing transcription factor. (1095 aa)
MTF2Metal-response element-binding transcription factor 2 isoform a. (593 aa)
SNAI2Protein snail-like protein 2. (268 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1115 aa)
CDH2Cadherin-2 preproprotein; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
EPOPElongin BC and polycomb repressive complex 2 associated protein. (379 aa)
MYOCDMyocardin. (986 aa)
FBXL17F-box and leucine rich repeat protein 17. (702 aa)
LMBR1LUncharacterized protein; Belongs to the LIMR family. (489 aa)
UFL1E3 UFM1-protein ligase 1. (793 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
RPS740S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
SEMA3CSemaphorin-3C; Belongs to the semaphorin family. (751 aa)
CHD2Chromodomain-helicase-DNA-binding protein 2 isoform 1. (1828 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (844 aa)
SEMA5BSemaphorin 5B. (1113 aa)
PAX2Paired box 2. (418 aa)
MEOX1Mesenchyme homeobox 1. (254 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (335 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
SEMA6CSema domain-containing protein; Belongs to the semaphorin family. (962 aa)
SEMA4CUncharacterized protein; Belongs to the semaphorin family. (833 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
FOXC1Forkhead box C1. (551 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (770 aa)
NELFBNegative elongation factor complex member B. (580 aa)
KBTBD8Kelch repeat and BTB domain containing 8. (601 aa)
BATFBasic leucine zipper ATF-like transcription factor. (137 aa)
HNF1BHepatocyte nuclear factor 1-beta. (557 aa)
SH2B3SH2B adaptor protein 3. (570 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
FAM172AFamily with sequence similarity 172 member A. (466 aa)
ELL3Elongation factor for RNA polymerase II 3. (399 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
SOX18SRY-box transcription factor 18. (384 aa)
BCL2BCL2 apoptosis regulator. (241 aa)
HOXB4Homeobox B4. (251 aa)
ENSMMUP00000070232Uncharacterized protein. (121 aa)
RUNX2RUNX family transcription factor 2. (647 aa)
FOXA1Fork-head domain-containing protein. (470 aa)
PHF5APHD finger-like domain-containing protein 5A. (110 aa)
HOXD4Homeobox D4. (255 aa)
EOMESEomesodermin. (703 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
GSCGoosecoid homeobox. (259 aa)
EDN3Endothelin 3. (257 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (454 aa)
GATA6Transcription factor GATA-6. (595 aa)
FRZBSecreted frizzled-related protein 3. (325 aa)
CMC4Uncharacterized protein. (92 aa)
FOXC2Forkhead box C2. (471 aa)
MLLT3MLLT3 super elongation complex subunit. (600 aa)
ENSMMUP00000075843Uncharacterized protein. (341 aa)
TCOF1LisH domain-containing protein. (1652 aa)
OVOL2Transcription factor Ovo-like 2. (275 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
EFNB1EPH-related receptor tyrosine kinase ligand 2; Belongs to the ephrin family. (346 aa)
ENSMMUP00000077734Uncharacterized protein. (122 aa)
PUM1Pumilio RNA binding family member 1. (1188 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (283 aa)
CDX2Caudal-type homeobox protein 2. (313 aa)
TBX3T-box transcription factor 3. (743 aa)
PWWP2APWWP domain containing 2A. (755 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ENSMMUP00000080573Uncharacterized protein. (121 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (772 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
ENSMMUP00000081054Uncharacterized protein. (321 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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