(27 nodes) Homeostasis of number of cells within a tissue network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
	KRAS	KRAS proto-oncogene, GTPase. (412 aa)
	CSF1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (555 aa)
	BAX	Uncharacterized protein. (279 aa)
	FH	Fumarate hydratase, mitochondrial. (510 aa)
	IL20RB	Fibronectin type-III domain-containing protein. (311 aa)
	LRRC45	Leucine rich repeat containing 45. (670 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
	GIGYF2	PERQ amino acid-rich with GYF domain-containing protein 2 isoform b. (1302 aa)
	GATA1	GATA binding protein 1. (413 aa)
	NOTCH1	Notch receptor 1. (2556 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	PRDM14	PR domain-containing protein 14. (571 aa)
	LIPA	Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (399 aa)
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
	BCL2	BCL2 apoptosis regulator. (241 aa)
	ILDR2	Immunoglobulin like domain containing receptor 2. (643 aa)
	CORO1A	Coronin; Belongs to the WD repeat coronin family. (461 aa)
	SASH3	Uncharacterized protein. (384 aa)
	F2R	Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
	IL7	Uncharacterized protein. (184 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	KLHL10	Kelch like family member 10. (608 aa)
	PRDX5	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (272 aa)
	GATA2	GATA binding protein 2. (480 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (573 aa)
	VPS54	Uncharacterized protein. (973 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT3	BCL2	ENSMMUP00000026292	ENSMMUP00000069881	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 apoptosis regulator.	0.929
AKT3	NOS3	ENSMMUP00000026292	ENSMMUP00000026905	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nitric oxide synthase; Produces nitric oxide (NO).	0.955
BAX	BCL2	ENSMMUP00000005212	ENSMMUP00000069881	Uncharacterized protein.	BCL2 apoptosis regulator.	0.840
BCL2	AKT3	ENSMMUP00000069881	ENSMMUP00000026292	BCL2 apoptosis regulator.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.929
BCL2	BAX	ENSMMUP00000069881	ENSMMUP00000005212	BCL2 apoptosis regulator.	Uncharacterized protein.	0.840
BCL2	IL7	ENSMMUP00000069881	ENSMMUP00000053290	BCL2 apoptosis regulator.	Uncharacterized protein.	0.643
BCL2	KRAS	ENSMMUP00000069881	ENSMMUP00000002635	BCL2 apoptosis regulator.	KRAS proto-oncogene, GTPase.	0.649
BCL2	NOTCH1	ENSMMUP00000069881	ENSMMUP00000022401	BCL2 apoptosis regulator.	Notch receptor 1.	0.457
CORO1A	SASH3	ENSMMUP00000060683	ENSMMUP00000055927	Coronin; Belongs to the WD repeat coronin family.	Uncharacterized protein.	0.416
CSF1	IL7	ENSMMUP00000003609	ENSMMUP00000053290	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Uncharacterized protein.	0.552
GATA1	GATA2	ENSMMUP00000021633	ENSMMUP00000038968	GATA binding protein 1.	GATA binding protein 2.	0.725
GATA2	GATA1	ENSMMUP00000038968	ENSMMUP00000021633	GATA binding protein 2.	GATA binding protein 1.	0.725
GATA2	PRDM14	ENSMMUP00000038968	ENSMMUP00000078546	GATA binding protein 2.	PR domain-containing protein 14.	0.432
IL20RB	IL7	ENSMMUP00000009698	ENSMMUP00000053290	Fibronectin type-III domain-containing protein.	Uncharacterized protein.	0.657
IL20RB	NOS3	ENSMMUP00000009698	ENSMMUP00000026905	Fibronectin type-III domain-containing protein.	Nitric oxide synthase; Produces nitric oxide (NO).	0.476
IL7	BCL2	ENSMMUP00000053290	ENSMMUP00000069881	Uncharacterized protein.	BCL2 apoptosis regulator.	0.643
IL7	CSF1	ENSMMUP00000053290	ENSMMUP00000003609	Uncharacterized protein.	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	0.552
IL7	IL20RB	ENSMMUP00000053290	ENSMMUP00000009698	Uncharacterized protein.	Fibronectin type-III domain-containing protein.	0.657
KRAS	BCL2	ENSMMUP00000002635	ENSMMUP00000069881	KRAS proto-oncogene, GTPase.	BCL2 apoptosis regulator.	0.649
KRAS	NOTCH1	ENSMMUP00000002635	ENSMMUP00000022401	KRAS proto-oncogene, GTPase.	Notch receptor 1.	0.427