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| | LACRT | Lacritin. (137 aa) |
| | ITGA4 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa) |
| | ARNT | Uncharacterized protein. (786 aa) |
| | IHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa) |
| | ZNF703 | Zinc finger protein 703. (591 aa) |
| | TACR1 | Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa) |
| | CLDN1 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa) |
| | IGF1 | Insulin like growth factor 1. (208 aa) |
| | EPGN | Epithelial mitogen. (154 aa) |
| | AREG | Amphiregulin. (252 aa) |
| | IQGAP3 | IQ motif containing GTPase activating protein 3. (1631 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (741 aa) |
| | YAP1 | Yes associated protein 1. (508 aa) |
| | VEGFC | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (421 aa) |
| | GHSR | Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa) |
| | MMP12 | Matrix metallopeptidase 12. (470 aa) |
| | ID1 | DNA-binding protein inhibitor ID-1 isoform a. (154 aa) |
| | CYP7B1 | Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (505 aa) |
| | CCR3 | C-C chemokine receptor type 3; Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1. (355 aa) |
| | VEGFA | PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (489 aa) |
| | ZBED9 | Zinc finger BED-type containing 9. (1325 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) |
| | NOG | Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa) |
| | HSF4 | Heat shock transcription factor 4. (475 aa) |
| | TEK | TEK receptor tyrosine kinase. (1124 aa) |
| | JAML | Uncharacterized protein. (443 aa) |
| | TNFSF12 | TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (356 aa) |
| | LAMB1 | Laminin subunit beta 1. (1786 aa) |
| | RPTOR | Regulatory associated protein of MTOR complex 1. (1335 aa) |
| | NF1 | Neurofibromin 1. (2867 aa) |
| | XBP1 | X-box binding protein 1. (376 aa) |
| | HMOX1 | Heme oxygenase 1. (288 aa) |
| | FGF2 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa) |
| | RREB1 | Ras responsive element binding protein 1. (1744 aa) |
| | FGFBP1 | Uncharacterized protein. (234 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa) |
| | CRNN | Cornulin. (494 aa) |
| | PAX2 | Paired box 2. (418 aa) |
| | C5AR2 | Complement component 5a receptor 2. (337 aa) |
| | FGF7 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa) |
| | FGF9 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1213 aa) |
| | APLNR | Apelin receptor; Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone. May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis. Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development. P [...] (380 aa) |
| | NR4A3 | Nuclear receptor subfamily 4 group A member 3. (717 aa) |
| | AR | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (895 aa) |
| | F7B371_MACMU | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (313 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (557 aa) |
| | VASH2 | Vasohibin 2. (355 aa) |
| | HTR2B | 5-hydroxytryptamine receptor 2B. (481 aa) |
| | BMP5 | Bone morphogenetic protein 5. (454 aa) |
| | SMO | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa) |
| | TGM1 | Transglutaminase 1. (818 aa) |
| | KDR | Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa) |
| | ATP7A | ATPase copper transporting alpha. (1500 aa) |
| | ADAM17 | Disintegrin and metalloproteinase domain-containing protein 17 preproprotein. (824 aa) |
| | VEGFB | Vascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa) |
| | NRARP | Notch-regulated ankyrin repeat-containing protein. (114 aa) |
| | SAAL1 | Serum amyloid A like 1. (529 aa) |
| | MAP2K5 | Dual specificity mitogen-activated protein kinase kinase 5 isoform A; Belongs to the protein kinase superfamily. (448 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (471 aa) |
| | LAMC1 | Laminin subunit gamma-1. (1608 aa) |
| | KDM5B | Lysine demethylase 5B. (1562 aa) |
| | CCL26 | C-C motif chemokine. (94 aa) |
| | VEGFD | Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (353 aa) |
| | SCN5A | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2017 aa) |
| | PKHD1 | PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (4072 aa) |
| | NOTCH1 | Notch receptor 1. (2556 aa) |
| | SPINK1 | Serine peptidase inhibitor, Kazal type 1. (79 aa) |
| | RESP18 | Regulated endocrine specific protein 18. (216 aa) |
| | PRKD2 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa) |
| | WNT7A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa) |
| | FLT4 | Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1362 aa) |
| | SCG2 | Uncharacterized protein. (617 aa) |
| | VIP | VIP peptides isoform 1 preproprotein. (170 aa) |
| | SIRT6 | NAD-dependent deacetylase sirtuin-6. (355 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | NRP2 | Neuropilin; Belongs to the neuropilin family. (925 aa) |
| | SEMA5A | Uncharacterized protein. (1080 aa) |
| | NKX2-6 | NK2 homeobox 6. (301 aa) |
| | RTN4 | Reticulon. (1193 aa) |
| | JCAD | Junctional cadherin 5 associated. (1356 aa) |
| | BMP6 | Bone morphogenetic protein 6. (511 aa) |
| | HRAS | Transforming protein p21. (189 aa) |
| | IRS2 | Insulin receptor substrate 2. (1394 aa) |
| | ESRP2 | Epithelial splicing regulatory protein 2. (715 aa) |
| | OSR2 | Odd-skipped related transciption factor 2. (276 aa) |
| | FGFR1 | Fibroblast growth factor receptor. (853 aa) |
| | PRKD1 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa) |
| | TCF7L2 | Transcription factor 7 like 2. (632 aa) |
| | NODAL | Nodal growth differentiation factor. (347 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa) |
| | LRG1 | Leucine rich alpha-2-glycoprotein 1. (383 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | GRN | Granulin precursor. (593 aa) |
| | EMC10 | Uncharacterized protein. (262 aa) |
| | HPN | Hepsin; Belongs to the peptidase S1 family. (471 aa) |
| | MYDGF | Myeloid derived growth factor. (205 aa) |
| | SFRP1 | Secreted frizzled-related protein 1. (314 aa) |
| | CDH3 | Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (829 aa) |
| | SIRT1 | Sirtuin 1. (743 aa) |
| | CXCL12 | C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa) |
| | NRP1 | Neuropilin; Belongs to the neuropilin family. (923 aa) |
| | SRSF6 | Serine and arginine rich splicing factor 6. (343 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) |
| | GATA2 | GATA binding protein 2. (480 aa) |
| | ACVRL1 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa) |
| | BTK | Tyrosine-protein kinase. (659 aa) |
| | FZD7 | Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (597 aa) |
| | HAS2 | Hyaluronan synthase 2. (552 aa) |
| | TNFAIP3 | Tumor necrosis factor alpha-induced protein 3. (790 aa) |
| | STAT3 | Signal transducer and activator of transcription. (871 aa) |
| | WDR48 | WD repeat domain 48. (745 aa) |
| | THBS4 | Thrombospondin 4. (987 aa) |
| | TGFA | Protransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. (166 aa) |
| | EGFR | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] (1210 aa) |
| | NOTCH2 | Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1044 aa) |
| | FGFR2 | Fibroblast growth factor receptor. (841 aa) |
| | DLX6 | Distal-less homeobox 6. (292 aa) |
| | STAT5A | Signal transducer and activator of transcription. (794 aa) |
| | MTA3 | Metastasis associated 1 family member 3. (621 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | ZNF304 | Uncharacterized protein. (659 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa) |
| | TBX1 | T-box transcription factor 1. (496 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa) |
| | ODAM | Odontogenic ameloblast-associated protein; Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface; Belongs to the ODAM family. (279 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | STXBP4 | Syntaxin-binding protein 4. (554 aa) |
| | PPP1R16B | Protein phosphatase 1 regulatory subunit 16B. (813 aa) |
| | SOX11 | Transcription factor SOX. (441 aa) |
| | HIF1A | Hypoxia-inducible factor 1-alpha isoform 1. (826 aa) |
| | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | AGTR1 | Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa) |
| | PGF | Placental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa) |
| | OSR1 | Odd-skipped related transcription factor 1. (266 aa) |
| | MDK | Midkine. (143 aa) |
| | ECM1 | Extracellular matrix protein 1 isoform 1. (540 aa) |
| | PTPRN | Protein tyrosine phosphatase receptor type N. (979 aa) |
| | PROK1 | Prokineticin 1. (159 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | GDF2 | Growth differentiation factor 2. (429 aa) |
| | MED1 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa) |
| | CCL24 | Uncharacterized protein. (231 aa) |
| | ANG | Angiogenin; Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) (By similarity). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo (By similarity). (146 aa) |
| | WNT2 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa) |
| | GHRL | Ghrelin and obestatin prepropeptide. (222 aa) |
| | CTNNB1 | Catenin beta-1. (781 aa) |
| | C5AR1 | C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. (362 aa) |
| | ERBB2 | Receptor protein-tyrosine kinase. (1437 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa) |
| | BMP2 | Bone morphogenetic protein 2. (396 aa) |
| | PDGFB | Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (265 aa) |
| | AGAP2 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform PIKE-L. (1192 aa) |
| | GPBAR1 | G protein-coupled bile acid receptor 1. (330 aa) |
| | BAD | Bcl2 antagonist of cell death. (167 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | PROX1 | Prospero homeobox protein 1. (737 aa) |
| | MST1 | Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa) |
| | FOXE3 | Forkhead box E3. (318 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa) |
| | RUNX2 | RUNX family transcription factor 2. (647 aa) |
| | B4GALT1 | Beta-1,4-galactosyltransferase 1. (398 aa) |
| | FGF1 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa) |
| | CYBA | Uncharacterized protein. (210 aa) |
| | NKX2-5 | NK2 homeobox 5. (324 aa) |
| | SOX9 | Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa) |
| | F3 | Tissue factor isoform 1. (296 aa) |
| | REG3A | Regenerating family member 3 alpha. (175 aa) |
| | NR4A1 | Nuclear receptor subfamily 4 group A member 1. (670 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (462 aa) |
| | DLX5 | Distal-less homeobox 5. (289 aa) |
| | JUN | Transcription factor AP-1; Belongs to the bZIP family. (334 aa) |
| | EGR3 | Early growth response 3. (349 aa) |
| | ARG1 | Arginase. (322 aa) |
| | IGF2 | Insulin like growth factor 2. (244 aa) |
| | REG3G | Regenerating family member 3 gamma. (174 aa) |
| | HTRA1 | Serine protease HTRA1. (481 aa) |
| | ST8SIA1 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (356 aa) |
| | BMP4 | Bone morphogenetic protein 4. (408 aa) |
| | HMX2 | Homeobox domain-containing protein. (273 aa) |
| | APELA | Uncharacterized protein. (54 aa) |
| | PDX1 | Pancreatic and duodenal homeobox 1. (281 aa) |
| | HLX | H2.0 like homeobox. (495 aa) |
| | SP1 | Uncharacterized protein. (845 aa) |
| | BMPR1A | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa) |
| | CCND1 | Uncharacterized protein; Belongs to the cyclin family. (303 aa) |
| | PTN | Uncharacterized protein. (172 aa) |
