STRINGSTRING
SHANK1 SHANK1 JPH4 JPH4 SPART SPART FGF12 FGF12 BLOC1S4 BLOC1S4 TNNC1 TNNC1 USH1G USH1G MYLK3 MYLK3 NLGN2 NLGN2 MTOR MTOR VTI1A VTI1A PMP22 PMP22 GRIN2C GRIN2C TNNI3 TNNI3 POU4F2 POU4F2 ATP8A2 ATP8A2 PEX5 PEX5 TIFAB TIFAB DLG4 DLG4 AGTPBP1 AGTPBP1 AARS1 AARS1 JPH3 JPH3 TCF15 TCF15 R3HDM1 R3HDM1 CAMTA1 CAMTA1 SLC6A3 SLC6A3 GPR88 GPR88 HEXB HEXB TNR TNR CLN8 CLN8 STAC STAC UCN UCN MECP2 MECP2 ABL1 ABL1 FXN FXN SCN1A SCN1A ADCY5 ADCY5 ADARB1 ADARB1 RPS6KB1 RPS6KB1 TMEM150C TMEM150C MYCBP2 MYCBP2 CHRND CHRND PVALEF PVALEF ITPR1 ITPR1 NRXN1 NRXN1 DVL1 DVL1 GRIN2A GRIN2A GBX1 GBX1 R3HDM2 R3HDM2 TNNI1 TNNI1 HOXD10 HOXD10 TNNC2 TNNC2 STRA6 STRA6 ZMPSTE24 ZMPSTE24 PTPRQ PTPRQ STAC3 STAC3 VPS54 VPS54 CTNNA2 CTNNA2 POU4F1 POU4F1 PAFAH1B1 PAFAH1B1 EDNRA EDNRA GLRB GLRB MAP1A MAP1A HEXA HEXA CHD8 CHD8 CSMD1 CSMD1 USH1C USH1C RCSD1 RCSD1 DRD3 DRD3 GM2A GM2A PNKD PNKD CHRNA1 CHRNA1 IGDCC3 IGDCC3 CLRN1 CLRN1 PRKN PRKN MYH1 MYH1 SLURP1 SLURP1 MYO7A MYO7A CHRNB1 CHRNB1 MYH14 MYH14 HOMER1 HOMER1 REST REST GRIN3A GRIN3A TNNT3 TNNT3 SLITRK6 SLITRK6 DCTN1 DCTN1 NPAS1 NPAS1 GLRA1 GLRA1 APP APP DRD2 DRD2 CDH23 CDH23 HOXA1 HOXA1 GIGYF2 GIGYF2 HERC1 HERC1 LRRC45 LRRC45 PCDH15 PCDH15 PRRT2 PRRT2 BCR BCR PTEN PTEN CNTNAP1 CNTNAP1 BACE1 BACE1 KCNQ1 KCNQ1 PENK PENK ALDH1A3 ALDH1A3 COMP COMP CCDC78 CCDC78 SLC1A3 SLC1A3 GRIN2D GRIN2D ASCL1 ASCL1 SHANK3 SHANK3 SYNM SYNM TNNI2 TNNI2 NEUROG1 NEUROG1 GCH1 GCH1 RBFOX1 RBFOX1 NEFL NEFL HMX3 HMX3 CSMD2 CSMD2 HIPK2 HIPK2 GRID2 GRID2 FOXS1 FOXS1 HOXC10 HOXC10 JSRP1 JSRP1 STAC2 STAC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SHANK1SH3 and multiple ankyrin repeat domains 1. (2163 aa)
JPH4Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (628 aa)
SPARTSpartin. (666 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
BLOC1S4Biogenesis of lysosomal organelles complex 1 subunit 4. (216 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (213 aa)
USH1GUSH1 protein network component sans. (461 aa)
MYLK3VPS35 retromer complex component. (1442 aa)
NLGN2COesterase domain-containing protein. (836 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
VTI1At-SNARE coiled-coil homology domain-containing protein. (228 aa)
PMP22Peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system; Belongs to the PMP-22/EMP/MP20 family. (160 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (1317 aa)
TNNI3Troponin T1, slow skeletal type. (443 aa)
POU4F2POU domain protein. (408 aa)
ATP8A2Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1291 aa)
PEX5Peroxisomal biogenesis factor 5. (660 aa)
TIFABTIFA inhibitor. (204 aa)
DLG4Uncharacterized protein; Belongs to the MAGUK family. (972 aa)
AGTPBP1ATP/GTP binding protein 1. (1226 aa)
AARS1Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (968 aa)
JPH3Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (748 aa)
TCF15BHLH domain-containing protein. (197 aa)
R3HDM1R3H domain containing 1. (1134 aa)
CAMTA1Calmodulin binding transcription activator 1. (1673 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (631 aa)
GPR88G_PROTEIN_RECEP_F1_2 domain-containing protein. (384 aa)
HEXBBeta-hexosaminidase. (557 aa)
TNRUncharacterized protein. (1358 aa)
CLN8Protein CLN8. (286 aa)
STACSH3 and cysteine rich domain. (402 aa)
UCNUrocortin. (124 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
FXNFrataxin, mitochondrial isoform 1 preproprotein. (210 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2008 aa)
ADCY5Adenylate cyclase 5. (1263 aa)
ADARB1Adenosine deaminase RNA specific B1. (783 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (550 aa)
TMEM150CUncharacterized protein. (279 aa)
MYCBP2MYC binding protein 2. (4682 aa)
CHRNDCholinergic receptor nicotinic delta subunit. (573 aa)
PVALEFParvalbumin like EF-hand containing. (133 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform 3. (2758 aa)
NRXN1Uncharacterized protein. (1547 aa)
DVL1Dishevelled segment polarity protein 1. (695 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
GBX1Gastrulation brain homeobox 1. (362 aa)
R3HDM2R3H domain containing 2. (1043 aa)
TNNI1Uncharacterized protein. (187 aa)
HOXD10Homeobox D10. (340 aa)
TNNC2Troponin C2, fast skeletal type. (345 aa)
STRA6Stimulated by retinoic acid 6. (707 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
PTPRQProtein tyrosine phosphatase receptor type Q. (2299 aa)
STAC3SH3 and cysteine-rich domain-containing protein 3. (364 aa)
VPS54Uncharacterized protein. (973 aa)
CTNNA2Catenin alpha 2. (953 aa)
POU4F1POU domain protein. (423 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (411 aa)
EDNRAUncharacterized protein; Belongs to the G-protein coupled receptor 1 family. (427 aa)
GLRBGlycine receptor subunit beta isoform A; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (497 aa)
MAP1AMicrotubule associated protein 1A. (3012 aa)
HEXABeta-hexosaminidase. (554 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2581 aa)
CSMD1CUB and Sushi multiple domains 1. (3564 aa)
USH1CUSH1 protein network component harmonin. (899 aa)
RCSD1RCSD domain containing 1. (475 aa)
DRD3G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (400 aa)
GM2AGM2 ganglioside activator. (227 aa)
PNKDPNKD metallo-beta-lactamase domain containing. (415 aa)
CHRNA1Cholinergic receptor nicotinic alpha 1 subunit. (502 aa)
IGDCC3Immunoglobulin superfamily DCC subclass member 3. (813 aa)
CLRN1Clarin 1. (245 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
MYH1Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1940 aa)
SLURP1Secreted LY6/PLAUR domain containing 1. (103 aa)
MYO7AMyosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2215 aa)
CHRNB1Cholinergic receptor nicotinic beta 1 subunit. (501 aa)
MYH14Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2035 aa)
HOMER1Homer scaffold protein 1. (374 aa)
RESTRE1 silencing transcription factor. (1095 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1115 aa)
TNNT3Troponin T3, fast skeletal type. (289 aa)
SLITRK6SLIT and NTRK like family member 6. (841 aa)
DCTN1CAP-Gly domain-containing protein. (1433 aa)
NPAS1Neuronal PAS domain protein 1. (591 aa)
GLRA1Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (449 aa)
APPAmyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (751 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (490 aa)
CDH23Cadherin related 23. (3354 aa)
HOXA1Homeobox protein Hox-1F. (335 aa)
GIGYF2PERQ amino acid-rich with GYF domain-containing protein 2 isoform b. (1302 aa)
HERC1HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. (4853 aa)
LRRC45Leucine rich repeat containing 45. (670 aa)
PCDH15Protocadherin related 15. (1960 aa)
PRRT2Proline-rich transmembrane protein 2 isoform 1. (340 aa)
BCRBCR activator of RhoGEF and GTPase. (1271 aa)
PTENUncharacterized protein. (589 aa)
CNTNAP1Uncharacterized protein. (1382 aa)
BACE1Beta-secretase 1 isoform A preproprotein; Belongs to the peptidase A1 family. (501 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (676 aa)
PENKProenkephalin. (300 aa)
ALDH1A3Aldehyde dehydrogenase family 1 member A3; Belongs to the aldehyde dehydrogenase family. (512 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
CCDC78Coiled-coil domain containing 78. (590 aa)
SLC1A3Amino acid transporter. (549 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (1336 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (238 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1730 aa)
SYNMSynemin; Belongs to the intermediate filament family. (1565 aa)
TNNI2Troponin I2, fast skeletal type. (182 aa)
NEUROG1Neurogenin 1. (237 aa)
GCH1GTP cyclohydrolase 1. (250 aa)
RBFOX1RNA binding protein fox-1 homolog 1; RNA-binding protein that regulates alternative splicing events. (428 aa)
NEFLNeurofilament light polypeptide; Belongs to the intermediate filament family. (543 aa)
HMX3H6 family homeobox 3. (357 aa)
CSMD2CUB and Sushi multiple domains 2. (3606 aa)
HIPK2Homeodomain interacting protein kinase 2. (1212 aa)
GRID2Glutamate ionotropic receptor delta type subunit 2. (1007 aa)
FOXS1Forkhead box S1. (330 aa)
HOXC10Homeobox protein Hox-C10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (342 aa)
JSRP1Junctional sarcoplasmic reticulum protein 1. (353 aa)
STAC2SH3 and cysteine rich domain 2. (411 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
Server load: low (14%) [HD]