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| | SLCO3A1 | Solute carrier organic anion transporter family member. (710 aa) |
| | TRIM32 | E3 ubiquitin-protein ligase TRIM32. (653 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | ENSMMUP00000078044 | Uncharacterized protein. (84 aa) |
| | S100A12 | S100 calcium binding protein A12; Belongs to the S-100 family. (90 aa) |
| | EP300 | Histone acetyltransferase p300. (2414 aa) |
| | TRIM21 | E3 ubiquitin-protein ligase TRIM21. (475 aa) |
| | ENSMMUP00000075586 | PPIase cyclophilin-type domain-containing protein. (165 aa) |
| | RNF31 | Uncharacterized protein. (1146 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (462 aa) |
| | ITGB2 | Integrin beta. (911 aa) |
| | PYCARD | Apoptosis-associated speck-like protein containing a CARD isoform a. (195 aa) |
| | PRKCI | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa) |
| | CLU | Clusterin; Belongs to the clusterin family. (489 aa) |
| | TRIM13 | Tripartite motif containing 13. (406 aa) |
| | ENSMMUP00000067677 | Nucleoplasmin domain-containing protein. (183 aa) |
| | EIF2AK2 | Eukaryotic translation initiation factor 2 alpha kinase 2. (554 aa) |
| | ANKRD42 | Ankyrin repeat domain 42. (509 aa) |
| | TRIM27 | Zinc finger protein RFP. (513 aa) |
| | TRIM5 | Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1- UBE2N (als [...] (496 aa) |
| | CTH | Uncharacterized protein. (434 aa) |
| | PSMA6 | Proteasome subunit alpha type. (246 aa) |
| | ENSMMUP00000048641 | Uncharacterized protein. (258 aa) |
| | S100A8 | Protein S100; Belongs to the S-100 family. (93 aa) |
| | ENSMMUP00000047529 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (143 aa) |
| | ERC1 | ELKS/RAB6-interacting/CAST family member 1. (1120 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1044 aa) |
| | LOC100430373 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (165 aa) |
| | MTDH | Metadherin. (612 aa) |
| | CIB1 | Calcium and integrin-binding protein 1. (191 aa) |
| | SPHK1 | Sphingosine kinase 1. (470 aa) |
| | ENSMMUP00000066266 | Uncharacterized protein. (188 aa) |
| | IRAK2 | Interleukin 1 receptor associated kinase 2. (666 aa) |
| | DDRGK1 | DDRGK domain-containing protein 1. (314 aa) |
| | AIM2 | Absent in melanoma 2. (343 aa) |
| | CX3CR1 | C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa) |
| | ZBTB7A | Zinc finger and BTB domain containing 7A. (692 aa) |
| | TRIM38 | Tripartite motif containing 38. (465 aa) |
| | RBCK1 | RanBP-type and C3HC4-type zinc finger-containing protein 1 isoform 2. (510 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) |
| | MAP3K13 | Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa) |
| | IRAK3 | Interleukin 1 receptor associated kinase 3. (596 aa) |
| | CARD11 | Caspase recruitment domain family member 11. (1154 aa) |
| | TRIM62 | Tripartite motif containing 62. (741 aa) |
| | TRAF1 | TNF receptor-associated factor. (416 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | CAT | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (533 aa) |
| | TRIM14 | Tripartite motif containing 14. (442 aa) |
| | TLR9 | TIR domain-containing protein. (1032 aa) |
| | NTRK1 | Tyrosine-protein kinase receptor. (816 aa) |
| | FLOT2 | Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa) |
| | NOD1 | Nucleotide binding oligomerization domain containing 1. (953 aa) |
| | TRIM6 | Uncharacterized protein. (559 aa) |
| | FER | Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa) |
| | FLOT1 | Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. (439 aa) |
| | CAV1 | Caveolin 1. (303 aa) |
| | MALT1 | MALT1 paracaspase. (824 aa) |
| | LTF | Lactotransferrin; Belongs to the transferrin family. (747 aa) |
| | APP | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (751 aa) |
| | LAMTOR5 | Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (169 aa) |
| | EDA2R | Ectodysplasin A2 receptor. (318 aa) |
| | RHEBL1 | Ras-like protein enriched in brain-like protein 1. (183 aa) |
| | NPM1 | Nucleophosmin isoform 1. (294 aa) |
| | PPIA | Peptidyl-prolyl cis-trans isomerase A, N-terminally processed; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding; Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. (165 aa) |
| | TRIML1 | Tripartite motif family like 1. (468 aa) |
| | PIDD1 | P53-induced death domain protein 1. (913 aa) |
| | RTKN2 | Rhotekin 2. (609 aa) |
| | NTSR1 | Neurotensin receptor type 1; Belongs to the G-protein coupled receptor 1 family. (418 aa) |
| | EDA | Ectodysplasin A; Belongs to the tumor necrosis factor family. (391 aa) |
| | TNFSF11 | Tumor necrosis factor ligand superfamily member. (317 aa) |
| | PRKD2 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa) |
| | RIPK4 | Receptor interacting serine/threonine kinase 4. (786 aa) |
| | TRAF6 | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa) |
| | AGER | Uncharacterized protein. (403 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (725 aa) |
| | PRKCZ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa) |
| | PRKCQ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (739 aa) |
| | NLRC4 | NLR family CARD domain containing 4. (1024 aa) |
| | TLR3 | Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa) |
| | PRKD1 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa) |
| | IL1RAP | Interleukin-1 receptor accessory protein; Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; bindin [...] (687 aa) |
| | TRIM68 | E3 ubiquitin-protein ligase TRIM68. (485 aa) |
| | ADAM8 | ADAM metallopeptidase domain 8. (823 aa) |
| | NTS | Neurotensin/neuromedin N. (170 aa) |
| | TRIML2 | Tripartite motif family like 2. (437 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1. (756 aa) |
| | TRIM52 | Tripartite motif containing 52. (276 aa) |
| | F6PMJ6_MACMU | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (165 aa) |
| | MTPN | Myotrophin. (118 aa) |
| | LOC716527 | Flotillin-2. (428 aa) |
| | IL18RAP | Interleukin 18 receptor accessory protein. (598 aa) |
| | RPS3 | 40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa) |
| | TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa) |
| | PLA2G1B | Phospholipase A(2). (148 aa) |
| | TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa) |
| | F6YD24_MACMU | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (165 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (489 aa) |
| | CD40LG | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (261 aa) |
| | BTK | Tyrosine-protein kinase. (659 aa) |
| | MID2 | Putative E3 ubiquitin-protein ligase MID2 isoform 1. (735 aa) |
| | TRIM37 | Uncharacterized protein. (983 aa) |
| | RPS6KA5 | Ribosomal protein S6 kinase. (802 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | STAT3 | Signal transducer and activator of transcription. (871 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (544 aa) |
| | UBE2N | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (210 aa) |
| | CD36 | CD36 molecule; Belongs to the CD36 family. (472 aa) |
| | ENSMMUP00000072883 | Nucleoplasmin domain-containing protein. (250 aa) |
| | LOC699631 | Proteasome subunit alpha type. (206 aa) |
| | CX3CL1 | C-X3-C motif chemokine ligand 1. (407 aa) |
| | TRADD | Tumor necrosis factor receptor type 1-associated DEATH domain protein. (308 aa) |
| | TRAPPC9 | Trafficking protein particle complex 9. (913 aa) |
| | AMH | Anti-Mullerian hormone. (561 aa) |
| | ENSMMUP00000071350 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (165 aa) |
| | ENSMMUP00000071080 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (165 aa) |
| | TIRAP | Toll/interleukin-1 receptor domain-containing adapter protein isoform a. (220 aa) |
| | TRIM22 | E3 ubiquitin-protein ligase TRIM22 isoform 1. (498 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa) |
| | CAPN3 | Calpain 3; Belongs to the peptidase C2 family. (821 aa) |
| | CLOCK | Clock circadian regulator. (852 aa) |
| | TFRC | Transferrin receptor protein 1. (760 aa) |
| | TNFRSF11A | TNF receptor superfamily member 11a. (615 aa) |
| | TRIM15 | Tripartite motif-containing protein 15; Belongs to the TRIM/RBCC family. (465 aa) |
| | CARD9 | Caspase recruitment domain family member 9. (535 aa) |
| | CD40 | Tumor necrosis factor receptor superfamily member 5 isoform 1. (278 aa) |
| | TRIM8 | Putative E3 ubiquitin-protein ligase TRIM8. (551 aa) |
| | ROR1 | Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa) |
| | ARHGEF2 | Rho/Rac guanine nucleotide exchange factor 2. (1245 aa) |
| | F7DC82_MACMU | Uncharacterized protein. (293 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) |
| | DHX9 | ATP-dependent RNA helicase A. (1275 aa) |
| | BCL10 | BCL10 immune signaling adaptor. (233 aa) |
| | TERF2IP | Telomeric repeat-binding factor 2-interacting protein 1. (400 aa) |
| | DHX33 | DEAH-box helicase 33. (766 aa) |
| | RNF25 | Ring finger protein 25. (463 aa) |
| | S100A9 | Protein S100; Belongs to the S-100 family. (114 aa) |
| | RPS6KA4 | Ribosomal protein S6 kinase. (772 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | CRNN | Cornulin. (494 aa) |
| | IL18R1 | Interleukin 18 receptor 1. (540 aa) |
| | CARD17 | Caspase recruitment domain family member 17. (110 aa) |
| | ALK | Tyrosine-protein kinase receptor. (1620 aa) |
| | AR | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (895 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (513 aa) |
| | TNFSF18 | Tumor necrosis factor ligand 2A. (199 aa) |
| | RAB7B | Ras-related protein Rab-7b. (199 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa) |
| | CARD14 | Caspase recruitment domain family member 14. (1004 aa) |
