(31 nodes) Smooth muscle cell differentiation network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TBX18	T-box transcription factor 18. (556 aa)
	MYOCD	Myocardin. (986 aa)
	NOTCH1	Notch receptor 1. (2556 aa)
	MRTFB	Myocardin related transcription factor B. (1135 aa)
	ACVR1	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
	SRF	Serum response factor. (508 aa)
	EDNRA	Uncharacterized protein; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	EFEMP2	EGF containing fibulin extracellular matrix protein 2. (576 aa)
	MEF2C	Myocyte-specific enhancer factor 2C isoform 1. (473 aa)
	EDNRB	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (527 aa)
	TBX2	T-box transcription factor 2. (712 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	HEY1	Hairy/enhancer-of-split related with YRPW motif protein 1 isoform a. (304 aa)
	MECP2	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
	MRTFA	Myocardin related transcription factor A. (1083 aa)
	NFATC4	Nuclear factor of activated T cells 4. (961 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	HEY2	Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
	FOXF1	Forkhead box F1. (432 aa)
	ADM	Adrenomedullin. (211 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	GATA6	Transcription factor GATA-6. (595 aa)
	TMEM204	Transmembrane protein 204. (226 aa)
	ENG	Endoglin. (672 aa)
	ITGA8	Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	RAMP2	Receptor activity-modifying protein 2. (175 aa)
	TBX3	T-box transcription factor 3. (743 aa)
	COMP	Cartilage oligomeric matrix protein. (757 aa)
	MESP1	Mesoderm posterior bHLH transcription factor 1. (272 aa)
	QKI	KH domain-containing protein. (333 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVR1	BMP4	ENSMMUP00000024342	ENSMMUP00000077296	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.988
ACVR1	ENG	ENSMMUP00000024342	ENSMMUP00000076624	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Endoglin.	0.569
ADM	RAMP2	ENSMMUP00000065934	ENSMMUP00000002868	Adrenomedullin.	Receptor activity-modifying protein 2.	0.999
BMP4	ACVR1	ENSMMUP00000077296	ENSMMUP00000024342	Bone morphogenetic protein 4.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.988
BMP4	CTNNB1	ENSMMUP00000077296	ENSMMUP00000062910	Bone morphogenetic protein 4.	Catenin beta-1.	0.402
BMP4	FGF10	ENSMMUP00000077296	ENSMMUP00000053581	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.709
BMP4	FOXF1	ENSMMUP00000077296	ENSMMUP00000063792	Bone morphogenetic protein 4.	Forkhead box F1.	0.622
BMP4	GATA6	ENSMMUP00000077296	ENSMMUP00000073874	Bone morphogenetic protein 4.	Transcription factor GATA-6.	0.608
BMP4	NOTCH1	ENSMMUP00000077296	ENSMMUP00000022401	Bone morphogenetic protein 4.	Notch receptor 1.	0.509
BMP4	TBX3	ENSMMUP00000077296	ENSMMUP00000079291	Bone morphogenetic protein 4.	T-box transcription factor 3.	0.604
COMP	ITGA8	ENSMMUP00000008575	ENSMMUP00000076931	Cartilage oligomeric matrix protein.	Integrin subunit alpha 8; Belongs to the integrin alpha chain family.	0.737
CTNNB1	BMP4	ENSMMUP00000062910	ENSMMUP00000077296	Catenin beta-1.	Bone morphogenetic protein 4.	0.402
CTNNB1	MEF2C	ENSMMUP00000062910	ENSMMUP00000042872	Catenin beta-1.	Myocyte-specific enhancer factor 2C isoform 1.	0.707
CTNNB1	NOTCH1	ENSMMUP00000062910	ENSMMUP00000022401	Catenin beta-1.	Notch receptor 1.	0.683
CTNNB1	WNT4	ENSMMUP00000062910	ENSMMUP00000068014	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.677
EDNRA	EDNRB	ENSMMUP00000034731	ENSMMUP00000051513	Uncharacterized protein; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	0.974
EDNRB	EDNRA	ENSMMUP00000051513	ENSMMUP00000034731	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein; Belongs to the G-protein coupled receptor 1 family.	0.974
EFEMP2	NFATC4	ENSMMUP00000037554	ENSMMUP00000060544	EGF containing fibulin extracellular matrix protein 2.	Nuclear factor of activated T cells 4.	0.484
ENG	ACVR1	ENSMMUP00000076624	ENSMMUP00000024342	Endoglin.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.569
FGF10	BMP4	ENSMMUP00000053581	ENSMMUP00000077296	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.709