(19 nodes) Pericardium development network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HEG1	Heart development protein with EGF like domains 1. (1486 aa)
	TBX20	T-box transcription factor TBX20. (447 aa)
	BMP7	Bone morphogenetic protein 7. (431 aa)
	WT1	WT1 transcription factor. (517 aa)
	BMP5	Bone morphogenetic protein 5. (454 aa)
	TBX5	T-box transcription factor 5. (518 aa)
	NOTCH1	Notch receptor 1. (2556 aa)
	RPGRIP1L	C2 domain-containing protein. (1273 aa)
	NKX2-6	NK2 homeobox 6. (301 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2565 aa)
	HAND2	BHLH domain-containing protein. (186 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	CCM2	PID domain-containing protein. (485 aa)
	BMP2	Bone morphogenetic protein 2. (396 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (713 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1345 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (462 aa)
	FLRT3	Fibronectin-like domain-containing leucine-rich transmembrane protein 3. (649 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP2	BMP5	ENSMMUP00000065891	ENSMMUP00000015562	Bone morphogenetic protein 2.	Bone morphogenetic protein 5.	0.602
BMP2	BMP7	ENSMMUP00000065891	ENSMMUP00000005446	Bone morphogenetic protein 2.	Bone morphogenetic protein 7.	0.830
BMP2	HAND2	ENSMMUP00000065891	ENSMMUP00000034525	Bone morphogenetic protein 2.	BHLH domain-containing protein.	0.410
BMP2	SMAD2	ENSMMUP00000065891	ENSMMUP00000045810	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.694
BMP2	SMAD3	ENSMMUP00000065891	ENSMMUP00000041841	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.514
BMP5	BMP2	ENSMMUP00000015562	ENSMMUP00000065891	Bone morphogenetic protein 5.	Bone morphogenetic protein 2.	0.602
BMP5	SMAD2	ENSMMUP00000015562	ENSMMUP00000045810	Bone morphogenetic protein 5.	Mothers against decapentaplegic homolog.	0.411
BMP7	BMP2	ENSMMUP00000005446	ENSMMUP00000065891	Bone morphogenetic protein 7.	Bone morphogenetic protein 2.	0.830
BMP7	SMAD2	ENSMMUP00000005446	ENSMMUP00000045810	Bone morphogenetic protein 7.	Mothers against decapentaplegic homolog.	0.656
BMP7	SMAD3	ENSMMUP00000005446	ENSMMUP00000041841	Bone morphogenetic protein 7.	Mothers against decapentaplegic homolog.	0.564
BMP7	WT1	ENSMMUP00000005446	ENSMMUP00000012938	Bone morphogenetic protein 7.	WT1 transcription factor.	0.513
CCM2	HEG1	ENSMMUP00000045974	ENSMMUP00000001553	PID domain-containing protein.	Heart development protein with EGF like domains 1.	0.481
CCM2	SETD2	ENSMMUP00000045974	ENSMMUP00000027795	PID domain-containing protein.	SET domain containing 2, histone lysine methyltransferase.	0.416
DLL4	NOTCH1	ENSMMUP00000066068	ENSMMUP00000022401	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.999
HAND2	BMP2	ENSMMUP00000034525	ENSMMUP00000065891	BHLH domain-containing protein.	Bone morphogenetic protein 2.	0.410
HAND2	TBX20	ENSMMUP00000034525	ENSMMUP00000016474	BHLH domain-containing protein.	T-box transcription factor TBX20.	0.702
HAND2	TBX5	ENSMMUP00000034525	ENSMMUP00000015631	BHLH domain-containing protein.	T-box transcription factor 5.	0.839
HEG1	CCM2	ENSMMUP00000001553	ENSMMUP00000045974	Heart development protein with EGF like domains 1.	PID domain-containing protein.	0.481
NKX2-6	TBX20	ENSMMUP00000027454	ENSMMUP00000016474	NK2 homeobox 6.	T-box transcription factor TBX20.	0.508
NKX2-6	TBX5	ENSMMUP00000027454	ENSMMUP00000015631	NK2 homeobox 6.	T-box transcription factor 5.	0.407