(29 nodes) Camera-type eye photoreceptor cell differentiation network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RP1	RP1 axonemal microtubule associated. (2152 aa)
	ROM1	Rod outer segment membrane protein 1. (351 aa)
	NRL	Neural retina leucine zipper. (239 aa)
	HCN1	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1. (885 aa)
	SDK2	Sidekick cell adhesion molecule 2. (2172 aa)
	BBS4	Bardet-Biedl syndrome 4 protein. (519 aa)
	PDE6C	Phosphodiesterase. (858 aa)
	NOTCH1	Notch receptor 1. (2556 aa)
	RPGRIP1L	C2 domain-containing protein. (1273 aa)
	USH1C	USH1 protein network component harmonin. (899 aa)
	RPGRIP1	RPGR interacting protein 1. (1235 aa)
	PROM1	Prominin 1. (855 aa)
	NDUFB6	RING-type domain-containing protein. (1085 aa)
	LOC713290	Uncharacterized protein. (702 aa)
	STAT3	Signal transducer and activator of transcription. (871 aa)
	RORB	Nuclear receptor ROR-beta. (459 aa)
	BHLHE23	Basic helix-loop-helix family member e23. (241 aa)
	SOX8	SRY-box transcription factor 8. (617 aa)
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	TTC8	Tetratricopeptide repeat domain 8. (531 aa)
	GNAT2	G protein subunit alpha transducin 2. (354 aa)
	CRB2	Crumbs cell polarity complex component 2. (1287 aa)
	THY1	Thy-1 membrane glycoprotein; May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. (177 aa)
	NTRK2	Tyrosine-protein kinase receptor. (838 aa)
	THRB	Thyroid hormone receptor beta. (524 aa)
	CABP4	Calcium binding protein 4. (303 aa)
	NAGLU	N-acetyl-alpha-glucosaminidase. (743 aa)
	DSCAM	DS cell adhesion molecule. (2010 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BBS4	RPGRIP1L	ENSMMUP00000018003	ENSMMUP00000027094	Bardet-Biedl syndrome 4 protein.	C2 domain-containing protein.	0.463
BBS4	TTC8	ENSMMUP00000018003	ENSMMUP00000006136	Bardet-Biedl syndrome 4 protein.	Tetratricopeptide repeat domain 8.	0.982
CABP4	ROM1	ENSMMUP00000077715	ENSMMUP00000079457	Calcium binding protein 4.	Rod outer segment membrane protein 1.	0.538
CABP4	RPGRIP1	ENSMMUP00000077715	ENSMMUP00000033138	Calcium binding protein 4.	RPGR interacting protein 1.	0.556
GNAT2	PDE6C	ENSMMUP00000007670	ENSMMUP00000019304	G protein subunit alpha transducin 2.	Phosphodiesterase.	0.953
GNAT2	ROM1	ENSMMUP00000007670	ENSMMUP00000079457	G protein subunit alpha transducin 2.	Rod outer segment membrane protein 1.	0.575
GNAT2	RPGRIP1	ENSMMUP00000007670	ENSMMUP00000033138	G protein subunit alpha transducin 2.	RPGR interacting protein 1.	0.433
IHH	SOX9	ENSMMUP00000001060	ENSMMUP00000073101	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.613
NOTCH1	SOX9	ENSMMUP00000022401	ENSMMUP00000073101	Notch receptor 1.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.439
NOTCH1	STAT3	ENSMMUP00000022401	ENSMMUP00000043986	Notch receptor 1.	Signal transducer and activator of transcription.	0.601
NRL	THRB	ENSMMUP00000079996	ENSMMUP00000074676	Neural retina leucine zipper.	Thyroid hormone receptor beta.	0.406
PDE6C	GNAT2	ENSMMUP00000019304	ENSMMUP00000007670	Phosphodiesterase.	G protein subunit alpha transducin 2.	0.953
PDE6C	ROM1	ENSMMUP00000019304	ENSMMUP00000079457	Phosphodiesterase.	Rod outer segment membrane protein 1.	0.626
PDE6C	RPGRIP1	ENSMMUP00000019304	ENSMMUP00000033138	Phosphodiesterase.	RPGR interacting protein 1.	0.416
PROM1	RPGRIP1	ENSMMUP00000035407	ENSMMUP00000033138	Prominin 1.	RPGR interacting protein 1.	0.471
ROM1	CABP4	ENSMMUP00000079457	ENSMMUP00000077715	Rod outer segment membrane protein 1.	Calcium binding protein 4.	0.538
ROM1	GNAT2	ENSMMUP00000079457	ENSMMUP00000007670	Rod outer segment membrane protein 1.	G protein subunit alpha transducin 2.	0.575
ROM1	PDE6C	ENSMMUP00000079457	ENSMMUP00000019304	Rod outer segment membrane protein 1.	Phosphodiesterase.	0.626
RPGRIP1	CABP4	ENSMMUP00000033138	ENSMMUP00000077715	RPGR interacting protein 1.	Calcium binding protein 4.	0.556
RPGRIP1	GNAT2	ENSMMUP00000033138	ENSMMUP00000007670	RPGR interacting protein 1.	G protein subunit alpha transducin 2.	0.433