STRINGSTRING
RANBP3L RANBP3L IHH IHH COL1A1 COL1A1 CTC1 CTC1 SH2B3 SH2B3 IGF1 IGF1 TMEM38B TMEM38B SP5 SP5 GP1BA GP1BA FOXP1 FOXP1 RYR1 RYR1 FLI1 FLI1 LEPR LEPR SLC38A10 SLC38A10 TEAD4 TEAD4 MMP13 MMP13 AMER1 AMER1 IFITM5 IFITM5 NEUROG1 NEUROG1 ABI1 ABI1 GJA1 GJA1 LEP LEP DHRS3 DHRS3 COL13A1 COL13A1 FOXC1 FOXC1 PLS3 PLS3 COMP COMP ZBTB16 ZBTB16 THPO THPO SERPINH1 SERPINH1 DCHS1 DCHS1 MAPK14 MAPK14 COL27A1 COL27A1 SEMA4D SEMA4D EXT1 EXT1 TP53 TP53 BMPR2 BMPR2 TGFBR2 TGFBR2 SH3PXD2B SH3PXD2B PTPN6 PTPN6 LOC694289 LOC694289 SKI SKI INPPL1 INPPL1 INSIG1 INSIG1 MEIS1 MEIS1 AKAP13 AKAP13 EPYC EPYC COL2A1 COL2A1 MIGA2 MIGA2 CHSY1 CHSY1 ANXA2 ANXA2 TGFB3 TGFB3 FREM1 FREM1 CER1 CER1 LRRC17 LRRC17 RARA RARA RARG RARG BGN BGN MMP16 MMP16 LRRK1 LRRK1 MYOC MYOC MMP14 MMP14 FLNA FLNA MAPK11 MAPK11 LTF LTF PIP4K2A PIP4K2A MPIG6B MPIG6B WNT1 WNT1 FGF8 FGF8 NPR2 NPR2 MEF2D MEF2D XYLT1 XYLT1 IFT80 IFT80 TNFSF11 TNFSF11 RPL13 RPL13 TRIP11 TRIP11 SMAD1 SMAD1 FGF18 FGF18 SMPD3 SMPD3 FOXN3 FOXN3 FGFR3 FGFR3 OSTN OSTN SRC SRC EVC EVC SFRP4 SFRP4 CCDC154 CCDC154 BMP6 BMP6 OSR2 OSR2 P3H1 P3H1 SPNS2 SPNS2 PAPPA2 PAPPA2 SULF1 SULF1 LTBP3 LTBP3 PHEX PHEX TGFB1 TGFB1 CCN4 CCN4 TBXT TBXT PEX7 PEX7 SRF SRF LOC704750 LOC704750 ACTN3 ACTN3 LRP5 LRP5 THBS3 THBS3 TRIM45 TRIM45 GP1BB GP1BB DDR2 DDR2 SBDS SBDS GLG1 GLG1 HAS2 HAS2 MEF2C MEF2C ZMPSTE24 ZMPSTE24 MEGF8 MEGF8 CITED4 CITED4 ANXA6 ANXA6 RHOA RHOA COL3A1 COL3A1 SNX10 SNX10 FGFR2 FGFR2 RARB RARB BMPR1B BMPR1B ATF2 ATF2 PLXNB1 PLXNB1 CITED2 CITED2 PTPN11 PTPN11 IFT172 IFT172 TMEM107 TMEM107 SCX SCX TFAP2A TFAP2A ITGB6 ITGB6 ASXL1 ASXL1 PTPRC PTPRC NSD2 NSD2 HOXD11 HOXD11 PPIB PPIB ALPL ALPL TRPV4 TRPV4 SLC10A7 SLC10A7 SCUBE2 SCUBE2 MAP2K6 MAP2K6 SMAD5 SMAD5 ECM1 ECM1 ADAMTS12 ADAMTS12 GPR68 GPR68 KIT KIT BNC2 BNC2 TSKU TSKU MED1 MED1 ATP6AP1 ATP6AP1 GP9 GP9 HOXA11 HOXA11 SHOX2 SHOX2 MINPP1 MINPP1 ABCB6 ABCB6 TTC9 TTC9 FAM20C FAM20C MATN1 MATN1 BMP2 BMP2 DYM DYM PAX1 PAX1 PHOSPHO2 PHOSPHO2 PITX2 PITX2 GLI3 GLI3 ACP5 ACP5 NAB2 NAB2 TIFAB TIFAB BBX BBX HOXB4 HOXB4 MCPH1 MCPH1 RUNX2 RUNX2 SMPD5 SMPD5 NOTUM NOTUM SULF2 SULF2 TGM2 TGM2 IMPAD1 IMPAD1 SOX9 SOX9 ZFPM1 ZFPM1 CHAD CHAD DLX5 DLX5 NPPC NPPC PDGFC PDGFC WASF2 WASF2 AXIN2 AXIN2 CDX1 CDX1 PHOSPHO1 PHOSPHO1 ENG ENG EP300 EP300 BMP4 BMP4 MSX1 MSX1 RAB23 RAB23 ATG9B ATG9B SBDS-2 SBDS-2 ADAMTS7 ADAMTS7 FGF4 FGF4 TMEM119 TMEM119 ACCS ACCS NAB1 NAB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RANBP3LRanBD1 domain-containing protein. (490 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
COL1A1Collagen alpha-1(I) chain preproprotein. (1464 aa)
CTC1CST telomere replication complex component 1. (1267 aa)
SH2B3SH2B adaptor protein 3. (570 aa)
IGF1Insulin like growth factor 1. (208 aa)
TMEM38BTrimeric intracellular cation channel type B. (291 aa)
SP5Sp5 transcription factor. (398 aa)
GP1BAGlycoprotein Ib platelet subunit alpha. (754 aa)
FOXP1Fork-head domain-containing protein. (695 aa)
RYR1Ryanodine receptor 1. (4928 aa)
FLI1Fli-1 proto-oncogene, ETS transcription factor. (475 aa)
LEPRLeptin receptor; Receptor for hormone LEP/leptin (By similarity). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductiv [...] (1163 aa)
SLC38A10Solute carrier family 38 member 10. (1152 aa)
TEAD4TUB like protein 3; Belongs to the TUB family. (728 aa)
MMP13Matrix metallopeptidase 13. (471 aa)
AMER1APC membrane recruitment protein 1. (1136 aa)
IFITM5Interferon induced transmembrane protein 5. (132 aa)
NEUROG1Neurogenin 1. (237 aa)
ABI1Abl interactor 1 isoform a. (508 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
DHRS3Short-chain dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
COL13A1Collagen type XIII alpha 1 chain. (717 aa)
FOXC1Forkhead box C1. (551 aa)
PLS3Uncharacterized protein. (637 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
ZBTB16Uncharacterized protein. (673 aa)
THPOThrombopoietin. (353 aa)
SERPINH1Serpin H1; Belongs to the serpin family. (418 aa)
DCHS1Dachsous cadherin-related 1. (3221 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
COL27A1Collagen type XXVII alpha 1 chain. (1853 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
SH3PXD2BSH3 and PX domains 2B. (937 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (626 aa)
LOC694289Uncharacterized protein. (394 aa)
SKISKI proto-oncogene. (730 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1315 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (277 aa)
MEIS1Meis homeobox 1. (465 aa)
AKAP13A-kinase anchoring protein 13. (2899 aa)
EPYCEpiphycan. (322 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
MIGA2Mitoguardin 2. (680 aa)
CHSY1Hexosyltransferase. (802 aa)
ANXA2Annexin. (357 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
FREM1FRAS1 related extracellular matrix 1. (2177 aa)
CER1Cerberus-related protein. (267 aa)
LRRC17Leucine rich repeat containing 17. (441 aa)
RARARetinoic acid receptor alpha isoform 1. (462 aa)
RARGRetinoic acid receptor gamma. (454 aa)
BGNBiglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (506 aa)
MMP16Matrix metallopeptidase 16. (607 aa)
LRRK1Leucine rich repeat kinase 1. (2015 aa)
MYOCMyocilin. (491 aa)
MMP14Matrix metalloproteinase-14 preproprotein. (582 aa)
FLNAFilamin-A isoform 2. (2647 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
LTFLactotransferrin; Belongs to the transferrin family. (747 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (432 aa)
MPIG6BMegakaryocyte and platelet inhibitory receptor G6b. (241 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
NPR2Guanylate cyclase. (1047 aa)
MEF2DMyocyte-specific enhancer factor 2D. (521 aa)
XYLT1Xylosyltransferase 1. (959 aa)
IFT80Intraflagellar transport protein 80 homolog isoform a. (777 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
RPL1360S ribosomal protein L13; Belongs to the eukaryotic ribosomal protein eL13 family. (211 aa)
TRIP11Thyroid hormone receptor interactor 11. (1819 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
FOXN3Forkhead box N3. (519 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
OSTNOsteocrin. (133 aa)
SRCTyrosine-protein kinase. (644 aa)
EVCEvC ciliary complex subunit 1. (992 aa)
SFRP4Secreted frizzled-related protein 4; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling. Has phosphaturic effects by specifically inhibiting sodium- dependent phosphate uptake. (346 aa)
CCDC154Coiled-coil domain containing 154. (535 aa)
BMP6Bone morphogenetic protein 6. (511 aa)
OSR2Odd-skipped related transciption factor 2. (276 aa)
P3H1Prolyl 3-hydroxylase 1 isoform 1. (736 aa)
SPNS2Sphingolipid transporter 2. (561 aa)
PAPPA2Pappalysin 2. (1790 aa)
SULF1Sulfatase 1. (1120 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1185 aa)
PHEXPhosphate regulating endopeptidase homolog X-linked. (749 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CCN4WNT1-inducible-signaling pathway protein 1. (367 aa)
TBXTT-box transcription factor T. (430 aa)
PEX7Peroxisomal biogenesis factor 7. (323 aa)
SRFSerum response factor. (508 aa)
LOC704750Cytochrome P450 26B1; Belongs to the cytochrome P450 family. (512 aa)
ACTN3Uncharacterized protein. (942 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1612 aa)
THBS3Uncharacterized protein. (956 aa)
TRIM45Tripartite motif-containing protein 45 isoform 1. (580 aa)
GP1BBGlycoprotein Ib platelet subunit beta. (208 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (896 aa)
SBDSUncharacterized protein. (226 aa)
GLG1Golgi glycoprotein 1. (1212 aa)
HAS2Hyaluronan synthase 2. (552 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform 1. (473 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
MEGF8Multiple EGF like domains 8. (2789 aa)
CITED4Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4. (232 aa)
ANXA6Annexin. (673 aa)
RHOARas homolog family member A. (209 aa)
COL3A1Collagen alpha-1(III) chain preproprotein. (1466 aa)
SNX10Sorting nexin 10. (227 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
RARBRetinoic acid receptor beta. (448 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
PLXNB1Plexin B1. (2140 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
IFT172Intraflagellar transport protein 172 homolog. (1749 aa)
TMEM107Transmembrane protein 107. (207 aa)
SCXScleraxis bHLH transcription factor. (201 aa)
TFAP2ATranscription factor AP-2 alpha. (445 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
ASXL1ASXL transcriptional regulator 1. (1541 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1310 aa)
NSD2Uncharacterized protein. (1362 aa)
HOXD11Homeobox D11. (338 aa)
PPIBPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
ALPLAlkaline phosphatase. (524 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (963 aa)
SLC10A7Sodium/bile acid cotransporter; Does not show transport activity towards bile acids or steroid sulfates; Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. (358 aa)
SCUBE2Signal peptide, CUB domain and EGF like domain containing 2. (1076 aa)
MAP2K6Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (335 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
ECM1Extracellular matrix protein 1 isoform 1. (540 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1598 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (365 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
BNC2Basonuclin 2. (1188 aa)
TSKUUncharacterized protein. (353 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (470 aa)
GP9Uncharacterized protein. (246 aa)
HOXA11Homeobox A11. (311 aa)
SHOX2Short stature homeobox 2. (355 aa)
MINPP1Uncharacterized protein. (635 aa)
ABCB6Uncharacterized protein. (1464 aa)
TTC9Tetratricopeptide repeat domain 9. (222 aa)
FAM20CFam20C domain-containing protein. (584 aa)
MATN1Matrilin 1. (495 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
DYMDymeclin. (724 aa)
PAX1Paired box 1. (535 aa)
PHOSPHO2Pyridoxal phosphate phosphatase PHOSPHO2. (241 aa)
PITX2Homeobox protein. (354 aa)
GLI3GLI family zinc finger 3. (1580 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
NAB2NGFI-A-binding protein 2. (525 aa)
TIFABTIFA inhibitor. (204 aa)
BBXBBX high mobility group box domain containing. (988 aa)
HOXB4Homeobox B4. (251 aa)
MCPH1Uncharacterized protein. (864 aa)
RUNX2RUNX family transcription factor 2. (647 aa)
SMPD5Uncharacterized protein. (381 aa)
NOTUMNotum, palmitoleoyl-protein carboxylesterase. (670 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. (948 aa)
TGM2Protein-glutamine gamma-glutamyltransferase 2 isoform a. (687 aa)
IMPAD1Inositol monophosphatase domain containing 1. (384 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
ZFPM1Zinc finger protein, FOG family member 1. (1024 aa)
CHADUncharacterized protein. (440 aa)
DLX5Distal-less homeobox 5. (289 aa)
NPPCC-type natriuretic peptide. (126 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (524 aa)
WASF2WASP family member 2. (498 aa)
AXIN2Axin 2. (862 aa)
CDX1Caudal type homeobox 1. (265 aa)
PHOSPHO1Phosphoethanolamine/phosphocholine phosphatase. (301 aa)
ENGEndoglin. (672 aa)
EP300Histone acetyltransferase p300. (2414 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
RAB23Ras-related protein Rab-23. (237 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (922 aa)
SBDS-2Uncharacterized protein. (250 aa)
ADAMTS7ADAM metallopeptidase with thrombospondin type 1 motif 7. (1691 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
TMEM119Uncharacterized protein. (280 aa)
ACCSExostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (857 aa)
NAB1Uncharacterized protein. (498 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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