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TGFBR3 TGFBR3 BMP7 BMP7 DHRS3 DHRS3 NOG NOG TP53 TP53 ENG ENG WNT5A WNT5A GATA6 GATA6 ZFPM1 ZFPM1 NKX2-5 NKX2-5 ZFPM2 ZFPM2 HEYL HEYL SLIT3 SLIT3 PROX1 PROX1 TGFB2 TGFB2 ISL1 ISL1 SMAD7 SMAD7 HEY2 HEY2 WNT11 WNT11 ROBO2 ROBO2 SOX11 SOX11 HEY1 HEY1 PARVA PARVA NSD2 NSD2 SAV1 SAV1 TBX1 TBX1 TBX2 TBX2 TGFBR1 TGFBR1 CITED2 CITED2 FGFR2 FGFR2 NOTCH2 NOTCH2 ROBO1 ROBO1 BMP4 BMP4 LRP2 LRP2 EGLN1 EGLN1 TBX3 TBX3 BMPR1A BMPR1A SEMA3C SEMA3C SMAD6 SMAD6 CITED4 CITED4 FGFRL1 FGFRL1 NRP1 NRP1 NOS3 NOS3 NRP2 NRP2 GATA4 GATA4 ACVR1 ACVR1 SMAD4 SMAD4 JAG1 JAG1 NOTCH1 NOTCH1 FGF8 FGF8 RBM15 RBM15 SOX4 SOX4 MDM2 MDM2 CCN1 CCN1 TBX20 TBX20 SMO SMO MKS1 MKS1 TBX5 TBX5 BMP5 BMP5 BMPR2 BMPR2 TGFBR2 TGFBR2 HAND1 HAND1 FZD2 FZD2 CHD7 CHD7 SLIT2 SLIT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
DHRS3Short-chain dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa)
ENGEndoglin. (672 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (462 aa)
GATA6Transcription factor GATA-6. (595 aa)
ZFPM1Zinc finger protein, FOG family member 1. (1024 aa)
NKX2-5NK2 homeobox 5. (324 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1177 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (477 aa)
SLIT3Slit guidance ligand 3. (1530 aa)
PROX1Prospero homeobox protein 1. (737 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ISL1ISL LIM homeobox 1. (413 aa)
SMAD7Mothers against decapentaplegic homolog. (462 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
ROBO2Roundabout guidance receptor 2. (1394 aa)
SOX11Transcription factor SOX. (441 aa)
HEY1Hairy/enhancer-of-split related with YRPW motif protein 1 isoform a. (304 aa)
PARVAParvin alpha. (372 aa)
NSD2Uncharacterized protein. (1362 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
TBX1T-box transcription factor 1. (496 aa)
TBX2T-box transcription factor 2. (712 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa)
ROBO1Roundabout guidance receptor 1. (1691 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
LRP2LDL receptor related protein 2. (4660 aa)
EGLN1Uncharacterized protein. (426 aa)
TBX3T-box transcription factor 3. (743 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SEMA3CSemaphorin-3C; Belongs to the semaphorin family. (751 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
CITED4Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4. (232 aa)
FGFRL1Fibroblast growth factor receptor like 1. (504 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (925 aa)
GATA4GATA binding protein 4. (443 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
NOTCH1Notch receptor 1. (2556 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
RBM15RNA binding motif protein 15. (925 aa)
SOX4Transcription factor SOX. (467 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
CCN1Cellular communication network factor 1. (381 aa)
TBX20T-box transcription factor TBX20. (447 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
TBX5T-box transcription factor 5. (518 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
CHD7Chromodomain-helicase-DNA-binding protein 7. (2998 aa)
SLIT2Slit guidance ligand 2. (1529 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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