STRINGSTRING
NOG NOG EGLN1 EGLN1 BMPR2 BMPR2 TGFBR2 TGFBR2 FZD2 FZD2 SOX4 SOX4 RBM15 RBM15 NOTCH1 NOTCH1 TBX3 TBX3 BMPR1A BMPR1A ACVR1 ACVR1 NOS3 NOS3 FGFRL1 FGFRL1 CITED4 CITED4 ROBO1 ROBO1 FGFR2 FGFR2 CITED2 CITED2 TGFBR1 TGFBR1 SAV1 SAV1 NSD2 NSD2 HEY1 HEY1 SOX11 SOX11 ROBO2 ROBO2 WNT11 WNT11 HEY2 HEY2 SMAD7 SMAD7 TGFB2 TGFB2 PROX1 PROX1 SLIT3 SLIT3 HEYL HEYL ZFPM2 ZFPM2 NKX2-5 NKX2-5 ZFPM1 ZFPM1 WNT5A WNT5A BMP4 BMP4 SMAD4 SMAD4 TGFBR3 TGFBR3 SLIT2 SLIT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
EGLN1Uncharacterized protein. (426 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
SOX4Transcription factor SOX. (467 aa)
RBM15RNA binding motif protein 15. (925 aa)
NOTCH1Notch receptor 1. (2556 aa)
TBX3T-box transcription factor 3. (743 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
FGFRL1Fibroblast growth factor receptor like 1. (504 aa)
CITED4Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4. (232 aa)
ROBO1Roundabout guidance receptor 1. (1691 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
NSD2Uncharacterized protein. (1362 aa)
HEY1Hairy/enhancer-of-split related with YRPW motif protein 1 isoform a. (304 aa)
SOX11Transcription factor SOX. (441 aa)
ROBO2Roundabout guidance receptor 2. (1394 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
SMAD7Mothers against decapentaplegic homolog. (462 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PROX1Prospero homeobox protein 1. (737 aa)
SLIT3Slit guidance ligand 3. (1530 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (477 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1177 aa)
NKX2-5NK2 homeobox 5. (324 aa)
ZFPM1Zinc finger protein, FOG family member 1. (1024 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (462 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
SLIT2Slit guidance ligand 2. (1529 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.