(43 nodes) Lung morphogenesis network (Macaca mulatta)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	SEC24B	SEC24 homolog B, COPII coat complex component. (1277 aa)
	PLOD3	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3. (780 aa)
	DLG5	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1948 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	TCF21	Transcription factor 21. (179 aa)
	WNT7B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	FOXA1	Fork-head domain-containing protein. (470 aa)
	RSPO2	Uncharacterized protein. (243 aa)
	HOXA5	Homeobox A5. (381 aa)
	STK40	Serine/threonine-protein kinase 40. (435 aa)
	SPRY2	Sprouty RTK signaling antagonist 2. (315 aa)
	NKX2-1	NK2 homeobox 1. (448 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	FOXF1	Forkhead box F1. (432 aa)
	SPRY1	Uncharacterized protein. (343 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	HPS1	HPS1 biogenesis of lysosomal organelles complex 3 subunit 1. (700 aa)
	SOX11	Transcription factor SOX. (441 aa)
	AP3B1	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1111 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
	TBX2	T-box transcription factor 2. (712 aa)
	LIF	LIF interleukin 6 family cytokine. (206 aa)
	RDH10	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
	FGFR2	Fibroblast growth factor receptor. (841 aa)
	SRF	Serum response factor. (508 aa)
	NODAL	Nodal growth differentiation factor. (347 aa)
	ESRP2	Epithelial splicing regulatory protein 2. (715 aa)
	GRHL2	Grainyhead like transcription factor 2. (625 aa)
	CELSR1	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (1818 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	CTSZ	Cathepsin Z; Belongs to the peptidase C1 family. (303 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
	LAMA1	Uncharacterized protein. (528 aa)
	CTSH	Cathepsin H; Belongs to the peptidase C1 family. (335 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
	EXT1	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
	HHIP	Hedgehog-interacting protein. (700 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	DAG1	Dystroglycan preproprotein. (894 aa)
	YAP1	Yes associated protein 1. (508 aa)
	KRAS	KRAS proto-oncogene, GTPase. (412 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	CTNNB1	ENSMMUP00000077296	ENSMMUP00000062910	Bone morphogenetic protein 4.	Catenin beta-1.	0.402
BMP4	FGF10	ENSMMUP00000077296	ENSMMUP00000053581	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.709
BMP4	FGF8	ENSMMUP00000077296	ENSMMUP00000020713	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.698
BMP4	FGFR2	ENSMMUP00000077296	ENSMMUP00000048184	Bone morphogenetic protein 4.	Fibroblast growth factor receptor.	0.509
BMP4	FOXF1	ENSMMUP00000077296	ENSMMUP00000063792	Bone morphogenetic protein 4.	Forkhead box F1.	0.622
BMP4	LIF	ENSMMUP00000077296	ENSMMUP00000052203	Bone morphogenetic protein 4.	LIF interleukin 6 family cytokine.	0.605
BMP4	NOG	ENSMMUP00000077296	ENSMMUP00000007646	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.997
BMP4	SHH	ENSMMUP00000077296	ENSMMUP00000065431	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.747
BMP4	TGFBR2	ENSMMUP00000077296	ENSMMUP00000013111	Bone morphogenetic protein 4.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.529
BMP4	WNT2	ENSMMUP00000077296	ENSMMUP00000062667	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.474
CTNNB1	BMP4	ENSMMUP00000062910	ENSMMUP00000077296	Catenin beta-1.	Bone morphogenetic protein 4.	0.402
CTNNB1	FGF8	ENSMMUP00000062910	ENSMMUP00000020713	Catenin beta-1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.458
CTNNB1	FGFR2	ENSMMUP00000062910	ENSMMUP00000048184	Catenin beta-1.	Fibroblast growth factor receptor.	0.452
CTNNB1	KRAS	ENSMMUP00000062910	ENSMMUP00000002635	Catenin beta-1.	KRAS proto-oncogene, GTPase.	0.637
CTNNB1	MAPK1	ENSMMUP00000062910	ENSMMUP00000016444	Catenin beta-1.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.555
CTNNB1	MAPK3	ENSMMUP00000062910	ENSMMUP00000053373	Catenin beta-1.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.661
CTNNB1	SHH	ENSMMUP00000062910	ENSMMUP00000065431	Catenin beta-1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.539
CTNNB1	SOX11	ENSMMUP00000062910	ENSMMUP00000056348	Catenin beta-1.	Transcription factor SOX.	0.547
CTNNB1	TGFBR2	ENSMMUP00000062910	ENSMMUP00000013111	Catenin beta-1.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.513
CTNNB1	WNT2	ENSMMUP00000062910	ENSMMUP00000062667	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.689