(35 nodes) Lung epithelium development network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KRAS	KRAS proto-oncogene, GTPase. (412 aa)
	TMEM38B	Trimeric intracellular cation channel type B. (291 aa)
	PKD1	Polycystin 1, transient receptor potential channel interacting. (4298 aa)
	THRA	Thyroid hormone receptor alpha. (486 aa)
	YAP1	Yes associated protein 1. (508 aa)
	FNDC3B	Fibronectin type III domain containing 3B. (1206 aa)
	ASCL1	Achaete-scute family bHLH transcription factor 1. (238 aa)
	SPDEF	SAM pointed domain containing ETS transcription factor. (335 aa)
	AGR2	Uncharacterized protein. (175 aa)
	GRHL2	Grainyhead like transcription factor 2. (625 aa)
	CREB1	Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa)
	ADAMTSL2	ADAMTS like 2. (958 aa)
	LOC114669852	Uncharacterized protein. (328 aa)
	STRA6	Stimulated by retinoic acid 6. (707 aa)
	RCN3	Uncharacterized protein. (326 aa)
	LTA4H	Leukotriene A(4) hydrolase; Belongs to the peptidase M1 family. (611 aa)
	NFIB	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (566 aa)
	RBBP9	Putative hydrolase RBBP9. (186 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	SAV1	Salvador family WW domain containing protein 1. (384 aa)
	KLF2	Kruppel like factor 2. (355 aa)
	AIMP2	Aminoacyl tRNA synthetase complex interacting multifunctional protein 2. (533 aa)
	PPP3R1	Uncharacterized protein. (171 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	NKX2-1	NK2 homeobox 1. (448 aa)
	HOXA5	Homeobox A5. (381 aa)
	FOXA1	Fork-head domain-containing protein. (470 aa)
	FOXJ1	Forkhead box J1. (421 aa)
	GATA6	Transcription factor GATA-6. (595 aa)
	THRB	Thyroid hormone receptor beta. (524 aa)
	WNT7B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	ERRFI1	ERBB receptor feedback inhibitor 1. (462 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGR2	FOXA1	ENSMMUP00000022436	ENSMMUP00000071089	Uncharacterized protein.	Fork-head domain-containing protein.	0.427
AGR2	SPDEF	ENSMMUP00000022436	ENSMMUP00000010266	Uncharacterized protein.	SAM pointed domain containing ETS transcription factor.	0.636
ASCL1	CREB1	ENSMMUP00000007582	ENSMMUP00000037790	Achaete-scute family bHLH transcription factor 1.	Cyclic AMP-responsive element-binding protein 1 isoform B.	0.514
ASCL1	NKX2-1	ENSMMUP00000007582	ENSMMUP00000066724	Achaete-scute family bHLH transcription factor 1.	NK2 homeobox 1.	0.521
ASCL1	SHH	ENSMMUP00000007582	ENSMMUP00000065431	Achaete-scute family bHLH transcription factor 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.614
BMP4	CTNNB1	ENSMMUP00000077296	ENSMMUP00000062910	Bone morphogenetic protein 4.	Catenin beta-1.	0.402
BMP4	FGF10	ENSMMUP00000077296	ENSMMUP00000053581	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.709
BMP4	GATA6	ENSMMUP00000077296	ENSMMUP00000073874	Bone morphogenetic protein 4.	Transcription factor GATA-6.	0.608
BMP4	SHH	ENSMMUP00000077296	ENSMMUP00000065431	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.747
BMP4	WNT2	ENSMMUP00000077296	ENSMMUP00000062667	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.474
CREB1	ASCL1	ENSMMUP00000037790	ENSMMUP00000007582	Cyclic AMP-responsive element-binding protein 1 isoform B.	Achaete-scute family bHLH transcription factor 1.	0.514
CREB1	CTNNB1	ENSMMUP00000037790	ENSMMUP00000062910	Cyclic AMP-responsive element-binding protein 1 isoform B.	Catenin beta-1.	0.678
CTNNB1	BMP4	ENSMMUP00000062910	ENSMMUP00000077296	Catenin beta-1.	Bone morphogenetic protein 4.	0.402
CTNNB1	CREB1	ENSMMUP00000062910	ENSMMUP00000037790	Catenin beta-1.	Cyclic AMP-responsive element-binding protein 1 isoform B.	0.678
CTNNB1	KLF2	ENSMMUP00000062910	ENSMMUP00000054426	Catenin beta-1.	Kruppel like factor 2.	0.417
CTNNB1	KRAS	ENSMMUP00000062910	ENSMMUP00000002635	Catenin beta-1.	KRAS proto-oncogene, GTPase.	0.637
CTNNB1	PKD1	ENSMMUP00000062910	ENSMMUP00000003803	Catenin beta-1.	Polycystin 1, transient receptor potential channel interacting.	0.408
CTNNB1	SHH	ENSMMUP00000062910	ENSMMUP00000065431	Catenin beta-1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.539
CTNNB1	WNT2	ENSMMUP00000062910	ENSMMUP00000062667	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.689
CTNNB1	WNT7B	ENSMMUP00000062910	ENSMMUP00000075667	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.476