(16 nodes) Trachea development network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HYDIN	HYDIN axonemal central pair apparatus protein. (5114 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
	RARA	Retinoic acid receptor alpha isoform 1. (462 aa)
	RARG	Retinoic acid receptor gamma. (454 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
	EDA	Ectodysplasin A; Belongs to the tumor necrosis factor family. (391 aa)
	SRF	Serum response factor. (508 aa)
	LEF1	Lymphoid enhancer binding factor 1. (414 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	FOXF1	Forkhead box F1. (432 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	HOXA5	Homeobox A5. (381 aa)
	RSPO2	Uncharacterized protein. (243 aa)
	WNT7B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	CTNNB1	ENSMMUP00000077296	ENSMMUP00000062910	Bone morphogenetic protein 4.	Catenin beta-1.	0.402
BMP4	FOXF1	ENSMMUP00000077296	ENSMMUP00000063792	Bone morphogenetic protein 4.	Forkhead box F1.	0.622
BMP4	LEF1	ENSMMUP00000077296	ENSMMUP00000044196	Bone morphogenetic protein 4.	Lymphoid enhancer binding factor 1.	0.519
BMP4	SHH	ENSMMUP00000077296	ENSMMUP00000065431	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.747
BMP4	TGFBR2	ENSMMUP00000077296	ENSMMUP00000013111	Bone morphogenetic protein 4.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.529
CTNNB1	BMP4	ENSMMUP00000062910	ENSMMUP00000077296	Catenin beta-1.	Bone morphogenetic protein 4.	0.402
CTNNB1	LEF1	ENSMMUP00000062910	ENSMMUP00000044196	Catenin beta-1.	Lymphoid enhancer binding factor 1.	0.992
CTNNB1	MAPK1	ENSMMUP00000062910	ENSMMUP00000016444	Catenin beta-1.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.555
CTNNB1	MAPK3	ENSMMUP00000062910	ENSMMUP00000053373	Catenin beta-1.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.661
CTNNB1	RARA	ENSMMUP00000062910	ENSMMUP00000016393	Catenin beta-1.	Retinoic acid receptor alpha isoform 1.	0.536
CTNNB1	SHH	ENSMMUP00000062910	ENSMMUP00000065431	Catenin beta-1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.539
CTNNB1	TGFBR2	ENSMMUP00000062910	ENSMMUP00000013111	Catenin beta-1.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.513
CTNNB1	WNT7B	ENSMMUP00000062910	ENSMMUP00000075667	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.476
FOXF1	BMP4	ENSMMUP00000063792	ENSMMUP00000077296	Forkhead box F1.	Bone morphogenetic protein 4.	0.622
FOXF1	RSPO2	ENSMMUP00000063792	ENSMMUP00000070766	Forkhead box F1.	Uncharacterized protein.	0.524
FOXF1	SHH	ENSMMUP00000063792	ENSMMUP00000065431	Forkhead box F1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.606
FOXF1	SRF	ENSMMUP00000063792	ENSMMUP00000033647	Forkhead box F1.	Serum response factor.	0.564
LEF1	BMP4	ENSMMUP00000044196	ENSMMUP00000077296	Lymphoid enhancer binding factor 1.	Bone morphogenetic protein 4.	0.519
LEF1	CTNNB1	ENSMMUP00000044196	ENSMMUP00000062910	Lymphoid enhancer binding factor 1.	Catenin beta-1.	0.992
LEF1	SHH	ENSMMUP00000044196	ENSMMUP00000065431	Lymphoid enhancer binding factor 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.436