(7 nodes) Bud elongation involved in lung branching network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SPRY2	Sprouty RTK signaling antagonist 2. (315 aa)
	YAP1	Yes associated protein 1. (508 aa)
	FGFR2	Fibroblast growth factor receptor. (841 aa)
	RDH10	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	SPRY1	Uncharacterized protein. (343 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	FGF10	ENSMMUP00000077296	ENSMMUP00000053581	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.709
BMP4	FGFR2	ENSMMUP00000077296	ENSMMUP00000048184	Bone morphogenetic protein 4.	Fibroblast growth factor receptor.	0.509
FGF10	BMP4	ENSMMUP00000053581	ENSMMUP00000077296	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.709
FGF10	FGFR2	ENSMMUP00000053581	ENSMMUP00000048184	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.999
FGFR2	BMP4	ENSMMUP00000048184	ENSMMUP00000077296	Fibroblast growth factor receptor.	Bone morphogenetic protein 4.	0.509
FGFR2	FGF10	ENSMMUP00000048184	ENSMMUP00000053581	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.999
SPRY1	SPRY2	ENSMMUP00000063316	ENSMMUP00000068217	Uncharacterized protein.	Sprouty RTK signaling antagonist 2.	0.558
SPRY2	SPRY1	ENSMMUP00000068217	ENSMMUP00000063316	Sprouty RTK signaling antagonist 2.	Uncharacterized protein.	0.558