(16 nodes) Mammary gland epithelial cell differentiation network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PRLR	Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (619 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1308 aa)
	ZNF703	Zinc finger protein 703. (591 aa)
	FOXB1	Forkhead box B1. (325 aa)
	HIF1A	Hypoxia-inducible factor 1-alpha isoform 1. (826 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
	AKT2	AKT serine/threonine kinase 2. (594 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	FOXF1	Forkhead box F1. (432 aa)
	HOXA5	Homeobox A5. (381 aa)
	LATS1	Large tumor suppressor kinase 1. (1224 aa)
	IRF6	Interferon regulatory factor 6 isoform 1. (467 aa)
	ID2	Inhibitor of DNA binding 2. (203 aa)
	CEBPB	CCAAT/enhancer-binding protein. (344 aa)
	PTCH1	Patched 1. (1452 aa)
	MGMT	Methylated-DNA--protein-cysteine methyltransferase. (238 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT2	ENSMMUP00000061388	ENSMMUP00000059674	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	AKT serine/threonine kinase 2.	0.968
AKT1	ERBB4	ENSMMUP00000061388	ENSMMUP00000002247	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Receptor protein-tyrosine kinase.	0.539
AKT1	HIF1A	ENSMMUP00000061388	ENSMMUP00000056541	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Hypoxia-inducible factor 1-alpha isoform 1.	0.621
AKT2	AKT1	ENSMMUP00000059674	ENSMMUP00000061388	AKT serine/threonine kinase 2.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.968
ERBB4	AKT1	ENSMMUP00000002247	ENSMMUP00000061388	Receptor protein-tyrosine kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.539
HIF1A	AKT1	ENSMMUP00000056541	ENSMMUP00000061388	Hypoxia-inducible factor 1-alpha isoform 1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.621
PTCH1	SMO	ENSMMUP00000051035	ENSMMUP00000015878	Patched 1.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.999
SMO	PTCH1	ENSMMUP00000015878	ENSMMUP00000051035	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	Patched 1.	0.999