(14 nodes) I-SMAD binding network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AXIN1	Axin 1. (867 aa)
	INTS8	Integrator complex subunit 8. (995 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	SMAD6	Mothers against decapentaplegic homolog. (496 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	TGFB1I1	Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (485 aa)
	SMAD9	Mothers against decapentaplegic homolog. (467 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	SMAD7	Mothers against decapentaplegic homolog. (462 aa)
	SMURF1	E3 ubiquitin-protein ligase. (757 aa)
	AXIN2	Axin 2. (862 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN1	AXIN2	ENSMMUP00000000814	ENSMMUP00000076172	Axin 1.	Axin 2.	0.978
AXIN1	CTNNB1	ENSMMUP00000000814	ENSMMUP00000062910	Axin 1.	Catenin beta-1.	0.997
AXIN1	SMAD3	ENSMMUP00000000814	ENSMMUP00000041841	Axin 1.	Mothers against decapentaplegic homolog.	0.451
AXIN1	SMAD4	ENSMMUP00000000814	ENSMMUP00000024106	Axin 1.	Mothers against decapentaplegic homolog.	0.406
AXIN1	SMAD7	ENSMMUP00000000814	ENSMMUP00000063793	Axin 1.	Mothers against decapentaplegic homolog.	0.565
AXIN1	SMURF1	ENSMMUP00000000814	ENSMMUP00000068857	Axin 1.	E3 ubiquitin-protein ligase.	0.623
AXIN2	AXIN1	ENSMMUP00000076172	ENSMMUP00000000814	Axin 2.	Axin 1.	0.978
AXIN2	CTNNB1	ENSMMUP00000076172	ENSMMUP00000062910	Axin 2.	Catenin beta-1.	0.994
AXIN2	SMAD7	ENSMMUP00000076172	ENSMMUP00000063793	Axin 2.	Mothers against decapentaplegic homolog.	0.414
AXIN2	SMURF1	ENSMMUP00000076172	ENSMMUP00000068857	Axin 2.	E3 ubiquitin-protein ligase.	0.595
CTNNB1	AXIN1	ENSMMUP00000062910	ENSMMUP00000000814	Catenin beta-1.	Axin 1.	0.997
CTNNB1	AXIN2	ENSMMUP00000062910	ENSMMUP00000076172	Catenin beta-1.	Axin 2.	0.994
CTNNB1	SMAD1	ENSMMUP00000062910	ENSMMUP00000024174	Catenin beta-1.	Mothers against decapentaplegic homolog.	0.584
CTNNB1	SMAD2	ENSMMUP00000062910	ENSMMUP00000045810	Catenin beta-1.	Mothers against decapentaplegic homolog.	0.829
CTNNB1	SMAD3	ENSMMUP00000062910	ENSMMUP00000041841	Catenin beta-1.	Mothers against decapentaplegic homolog.	0.868
CTNNB1	SMAD4	ENSMMUP00000062910	ENSMMUP00000024106	Catenin beta-1.	Mothers against decapentaplegic homolog.	0.758
CTNNB1	SMAD6	ENSMMUP00000062910	ENSMMUP00000044372	Catenin beta-1.	Mothers against decapentaplegic homolog.	0.432
CTNNB1	SMAD7	ENSMMUP00000062910	ENSMMUP00000063793	Catenin beta-1.	Mothers against decapentaplegic homolog.	0.623
CTNNB1	SMAD9	ENSMMUP00000062910	ENSMMUP00000051464	Catenin beta-1.	Mothers against decapentaplegic homolog.	0.407
CTNNB1	SMURF1	ENSMMUP00000062910	ENSMMUP00000068857	Catenin beta-1.	E3 ubiquitin-protein ligase.	0.453