43 items (Macaca mulatta) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	UBE2T	Ubiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (206 aa)
	ITCH	E3 ubiquitin-protein ligase. (918 aa)
	PRPF19	Pre-mRNA processing factor 19. (512 aa)
	UBE2S	Ubiquitin-conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (222 aa)
	UBE2E2	Ubiquitin-conjugating enzyme E2 E2; Belongs to the ubiquitin-conjugating enzyme family. (201 aa)
	ENSMMUP00000078057	Uncharacterized protein. (116 aa)
	TRIM21	E3 ubiquitin-protein ligase TRIM21. (475 aa)
	FBXW9	F-box and WD repeat domain containing 9. (502 aa)
	NEDD4	NEDD4 E3 ubiquitin protein ligase. (1319 aa)
	RNF186	Ring finger protein 186. (227 aa)
	PELI1	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
	HECTD1	E3 ubiquitin-protein ligase HECTD1. (2610 aa)
	ARIH2	RBR-type E3 ubiquitin transferase. (470 aa)
	UBE2G1	Ubiquitin conjugating enzyme E2 G1; Belongs to the ubiquitin-conjugating enzyme family. (187 aa)
	ENSMMUP00000062234	RBR-type E3 ubiquitin transferase. (228 aa)
	RNF152	RING finger protein 152. (203 aa)
	RNF126	Ring finger protein 126. (417 aa)
	ENSMMUP00000058534	UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa)
	TRAF1	TNF receptor-associated factor. (416 aa)
	RNF4	E3 ubiquitin ligase RNF4 isoform 1. (190 aa)
	UBE2N	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (210 aa)
	TRIM27	Zinc finger protein RFP. (513 aa)
	TRIM5	Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1- UBE2N (als [...] (496 aa)
	STUB1	STIP1 homology and U-box containing protein 1. (539 aa)
	RNF213	Ring finger protein 213. (5248 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
	UBE2O	Ubiquitin-conjugating enzyme E2 O. (1293 aa)
	RNF5	E3 ubiquitin-protein ligase RNF5. (180 aa)
	PRKN	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
	TRAF6	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa)
	TRIM56	E3 ubiquitin-protein ligase TRIM56. (755 aa)
	RNF115	E3 ubiquitin-protein ligase RNF115. (304 aa)
	TRAF3IP2	SEFIR domain-containing protein. (572 aa)
	WWP2	E3 ubiquitin-protein ligase. (870 aa)
	PELI3	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (469 aa)
	RNF168	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (661 aa)
	RNF135	Ring finger protein 135. (435 aa)
	UBE2E3	Ubiquitin-conjugating enzyme E2 E3; Belongs to the ubiquitin-conjugating enzyme family. (207 aa)
	BFAR	Bifunctional apoptosis regulator. (450 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (513 aa)
	ZFP91	Uncharacterized protein. (573 aa)
	UBE2V2	Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARIH2	ITCH	ENSMMUP00000065415	ENSMMUP00000016958	RBR-type E3 ubiquitin transferase.	E3 ubiquitin-protein ligase.	0.432
ARIH2	RNF4	ENSMMUP00000065415	ENSMMUP00000055969	RBR-type E3 ubiquitin transferase.	E3 ubiquitin ligase RNF4 isoform 1.	0.538
ENSMMUP00000058534	PELI1	ENSMMUP00000058534	ENSMMUP00000072501	UBIQUITIN_CONJUGAT_2 domain-containing protein.	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.446
ENSMMUP00000058534	PELI3	ENSMMUP00000058534	ENSMMUP00000004509	UBIQUITIN_CONJUGAT_2 domain-containing protein.	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.446
ENSMMUP00000058534	PRKN	ENSMMUP00000058534	ENSMMUP00000026859	UBIQUITIN_CONJUGAT_2 domain-containing protein.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.564
ENSMMUP00000058534	RNF168	ENSMMUP00000058534	ENSMMUP00000005384	UBIQUITIN_CONJUGAT_2 domain-containing protein.	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...]	0.767
ENSMMUP00000058534	RNF4	ENSMMUP00000058534	ENSMMUP00000055969	UBIQUITIN_CONJUGAT_2 domain-containing protein.	E3 ubiquitin ligase RNF4 isoform 1.	0.617
ENSMMUP00000058534	STUB1	ENSMMUP00000058534	ENSMMUP00000043126	UBIQUITIN_CONJUGAT_2 domain-containing protein.	STIP1 homology and U-box containing protein 1.	0.437
ENSMMUP00000058534	TRAF6	ENSMMUP00000058534	ENSMMUP00000024012	UBIQUITIN_CONJUGAT_2 domain-containing protein.	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]	0.558
ENSMMUP00000058534	UBE2E2	ENSMMUP00000058534	ENSMMUP00000017167	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin-conjugating enzyme E2 E2; Belongs to the ubiquitin-conjugating enzyme family.	0.639
ENSMMUP00000058534	UBE2E3	ENSMMUP00000058534	ENSMMUP00000010574	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin-conjugating enzyme E2 E3; Belongs to the ubiquitin-conjugating enzyme family.	0.635
ENSMMUP00000058534	UBE2G1	ENSMMUP00000058534	ENSMMUP00000064233	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin conjugating enzyme E2 G1; Belongs to the ubiquitin-conjugating enzyme family.	0.748
ENSMMUP00000058534	UBE2N	ENSMMUP00000058534	ENSMMUP00000051689	UBIQUITIN_CONJUGAT_2 domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.989
ENSMMUP00000058534	UBE2O	ENSMMUP00000058534	ENSMMUP00000034030	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin-conjugating enzyme E2 O.	0.700
ENSMMUP00000058534	UBE2S	ENSMMUP00000058534	ENSMMUP00000021692	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin-conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family.	0.765
ENSMMUP00000058534	UBE2T	ENSMMUP00000058534	ENSMMUP00000018144	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family.	0.652
ENSMMUP00000078057	UBE2N	ENSMMUP00000078057	ENSMMUP00000051689	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.518
ITCH	ARIH2	ENSMMUP00000016958	ENSMMUP00000065415	E3 ubiquitin-protein ligase.	RBR-type E3 ubiquitin transferase.	0.432
ITCH	RNF4	ENSMMUP00000016958	ENSMMUP00000055969	E3 ubiquitin-protein ligase.	E3 ubiquitin ligase RNF4 isoform 1.	0.405
ITCH	TRAF6	ENSMMUP00000016958	ENSMMUP00000024012	E3 ubiquitin-protein ligase.	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]	0.679