STRINGSTRING
ITGA3 ITGA3 IRX3 IRX3 PLCE1 PLCE1 ERBB4 ERBB4 FMN1 FMN1 PKD1 PKD1 HNF1B HNF1B NPHS2 NPHS2 BMP7 BMP7 ENPEP ENPEP FOXC1 FOXC1 NOG NOG TEK TEK CALB1 CALB1 UMOD UMOD GATA3 GATA3 FGF2 FGF2 DCHS1 DCHS1 HS3ST3A1 HS3ST3A1 EXT1 EXT1 PKD2 PKD2 PAX2 PAX2 AHI1 AHI1 WT1 WT1 ANGPT2 ANGPT2 MPV17 MPV17 NUP160 NUP160 PBX1 PBX1 COMMD5 COMMD5 PDGFRB PDGFRB IQGAP1 IQGAP1 SMO SMO NID1 NID1 COL4A4 COL4A4 NOTCH3 NOTCH3 DCHS2 DCHS2 HS2ST1 HS2ST1 CD34 CD34 WNT1 WNT1 FGF8 FGF8 WNK4 WNK4 NOTCH1 NOTCH1 SALL1 SALL1 ANGPT1 ANGPT1 JAG1 JAG1 SMAD4 SMAD4 SEC61A1 SEC61A1 AQP11 AQP11 GDNF GDNF WWTR1 WWTR1 GPR4 GPR4 NPHS1 NPHS1 GREB1 GREB1 PTPRO PTPRO DLL1 DLL1 SULF1 SULF1 SIX2 SIX2 EDNRA EDNRA PROM1 PROM1 LGR4 LGR4 DLG1 DLG1 NUP107 NUP107 GREB1L GREB1L MEF2C MEF2C GPC3 GPC3 MTSS1 MTSS1 NOTCH2 NOTCH2 KIF26B KIF26B KIRREL3 KIRREL3 PTCH1 PTCH1 EDNRB EDNRB MAGI2 MAGI2 LAMB2 LAMB2 EYA1 EYA1 ASXL1 ASXL1 FOXD1 FOXD1 HOXD11 HOXD11 PGF PGF MYO1E MYO1E OSR1 OSR1 NUP85 NUP85 PECAM1 PECAM1 ENSMMUP00000062204 ENSMMUP00000062204 HES5 HES5 KLF15 KLF15 NUP133 NUP133 PODXL PODXL LZTS2 LZTS2 WNT11 WNT11 CTNNB1 CTNNB1 IRX1 IRX1 HOXA11 HOXA11 KLHL3 KLHL3 WNT6 WNT6 SHH SHH BMP2 BMP2 PDGFB PDGFB GLI3 GLI3 WNT4 WNT4 REX1BD REX1BD ADAMTS16 ADAMTS16 SOX8 SOX8 BCL2 BCL2 WNT9B WNT9B FOXJ1 FOXJ1 FGF1 FGF1 HEYL HEYL SULF2 SULF2 ENSMMUP00000072696 ENSMMUP00000072696 SOX9 SOX9 COL4A3 COL4A3 BASP1 BASP1 FOXC2 FOXC2 WNT7B WNT7B TCF21 TCF21 SIX1 SIX1 IRX2 IRX2 BMP4 BMP4 EGR1 EGR1 HS3ST3B1 HS3ST3B1 TFAP2B TFAP2B LOC114672614 LOC114672614 GZF1 GZF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1064 aa)
IRX3Iroquois homeobox 3. (501 aa)
PLCE1Phosphoinositide phospholipase C. (2317 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
FMN1Formin 1. (1425 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4298 aa)
HNF1BHepatocyte nuclear factor 1-beta. (557 aa)
NPHS2NPHS2 stomatin family member, podocin. (506 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
ENPEPAminopeptidase. (957 aa)
FOXC1Forkhead box C1. (551 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
CALB1Calbindin 1. (261 aa)
UMODUromodulin. (641 aa)
GATA3GATA binding protein 3. (444 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
DCHS1Dachsous cadherin-related 1. (3221 aa)
HS3ST3A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (406 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (969 aa)
PAX2Paired box 2. (418 aa)
AHI1Abelson helper integration site 1. (1196 aa)
WT1WT1 transcription factor. (517 aa)
ANGPT2Angiopoietin 2. (496 aa)
MPV17Protein Mpv17; Belongs to the peroxisomal membrane protein PXMP2/4 family. (176 aa)
NUP160Nucleoporin 160. (1432 aa)
PBX1Pre-B-cell leukemia transcription factor 1 isoform 1. (430 aa)
COMMD5COMM domain containing 5. (299 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1667 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
NID1Nidogen-1. (1247 aa)
COL4A4Collagen type IV alpha 4 chain. (1692 aa)
NOTCH3Notch receptor 3. (2321 aa)
DCHS2Dachsous cadherin-related 2. (3366 aa)
HS2ST1Heparan sulfate 2-O-sulfotransferase 1 isoform 1. (356 aa)
CD34CD34 molecule. (385 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
WNK4WNK lysine deficient protein kinase 4. (1242 aa)
NOTCH1Notch receptor 1. (2556 aa)
SALL1Spalt like transcription factor 1. (1324 aa)
ANGPT1Angiopoietin-1 isoform 1. (498 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SEC61A1Protein transport protein Sec61 subunit alpha isoform 1. (476 aa)
AQP11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
GDNFGlial cell derived neurotrophic factor. (342 aa)
WWTR1WW domain containing transcription regulator 1. (432 aa)
GPR4G protein-coupled receptor 4; Belongs to the G-protein coupled receptor 1 family. (362 aa)
NPHS1NPHS1 adhesion molecule, nephrin. (1221 aa)
GREB1Growth regulating estrogen receptor binding 1. (1949 aa)
PTPROUncharacterized protein. (1216 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
SULF1Sulfatase 1. (1120 aa)
SIX2SIX homeobox 2. (292 aa)
EDNRAUncharacterized protein; Belongs to the G-protein coupled receptor 1 family. (427 aa)
PROM1Prominin 1. (855 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4. (951 aa)
DLG1Disks large homolog 1 isoform 2; Belongs to the MAGUK family. (926 aa)
NUP107Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (925 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1967 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform 1. (473 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (603 aa)
MTSS1MTSS I-BAR domain containing 1. (799 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa)
KIF26BKinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2107 aa)
KIRREL3Kirre like nephrin family adhesion molecule 3. (778 aa)
PTCH1Patched 1. (1452 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (527 aa)
MAGI2Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1452 aa)
LAMB2Laminin subunit beta-2. (1798 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
ASXL1ASXL transcriptional regulator 1. (1541 aa)
FOXD1Forkhead box D1. (468 aa)
HOXD11Homeobox D11. (338 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
MYO1EMyosin-Ie; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1108 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
NUP85Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (656 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (834 aa)
ENSMMUP00000062204Uncharacterized protein. (81 aa)
HES5Uncharacterized protein. (166 aa)
KLF15Krueppel-like factor 15. (416 aa)
NUP133Nucleoporin 133. (1157 aa)
PODXLPodocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (522 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (669 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
CTNNB1Catenin beta-1. (781 aa)
IRX1Iroquois homeobox 1. (480 aa)
HOXA11Homeobox A11. (311 aa)
KLHL3BTB domain-containing protein. (612 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (265 aa)
GLI3GLI family zinc finger 3. (1580 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
REX1BDUncharacterized protein. (657 aa)
ADAMTS16ADAM metallopeptidase with thrombospondin type 1 motif 16. (1275 aa)
SOX8SRY-box transcription factor 8. (617 aa)
BCL2BCL2 apoptosis regulator. (241 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
FOXJ1Forkhead box J1. (421 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (477 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. (948 aa)
ENSMMUP00000072696Uncharacterized protein. (103 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
COL4A3Collagen type IV alpha 3 chain. (1674 aa)
BASP1Brain acid soluble protein 1. (227 aa)
FOXC2Forkhead box C2. (471 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
TCF21Transcription factor 21. (179 aa)
SIX1SIX homeobox 1. (284 aa)
IRX2Iroquois homeobox 2. (500 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (545 aa)
HS3ST3B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (390 aa)
TFAP2BTranscription factor AP-2 beta. (504 aa)
LOC114672614Uncharacterized protein. (137 aa)
GZF1GDNF inducible zinc finger protein 1. (819 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
Server load: low (16%) [HD]