(14 nodes) Metanephric mesenchyme development network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	BMP7	Bone morphogenetic protein 7. (431 aa)
	SIX4	SIX homeobox 4. (772 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
	WT1	WT1 transcription factor. (517 aa)
	PAX2	Paired box 2. (418 aa)
	SIX1	SIX homeobox 1. (284 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (969 aa)
	BASP1	Brain acid soluble protein 1. (227 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	TCF21	Transcription factor 21. (179 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	OSR1	Odd-skipped related transcription factor 1. (266 aa)
	STAT1	Signal transducer and activator of transcription. (802 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BASP1	WT1	ENSMMUP00000074196	ENSMMUP00000012938	Brain acid soluble protein 1.	WT1 transcription factor.	0.437
BMP7	PAX2	ENSMMUP00000005446	ENSMMUP00000012018	Bone morphogenetic protein 7.	Paired box 2.	0.419
BMP7	SHH	ENSMMUP00000005446	ENSMMUP00000065431	Bone morphogenetic protein 7.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.519
BMP7	SMAD4	ENSMMUP00000005446	ENSMMUP00000024106	Bone morphogenetic protein 7.	Mothers against decapentaplegic homolog.	0.584
BMP7	WNT4	ENSMMUP00000005446	ENSMMUP00000068014	Bone morphogenetic protein 7.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.488
BMP7	WT1	ENSMMUP00000005446	ENSMMUP00000012938	Bone morphogenetic protein 7.	WT1 transcription factor.	0.513
OSR1	PAX2	ENSMMUP00000058804	ENSMMUP00000012018	Odd-skipped related transcription factor 1.	Paired box 2.	0.431
PAX2	BMP7	ENSMMUP00000012018	ENSMMUP00000005446	Paired box 2.	Bone morphogenetic protein 7.	0.419
PAX2	OSR1	ENSMMUP00000012018	ENSMMUP00000058804	Paired box 2.	Odd-skipped related transcription factor 1.	0.431
PAX2	SHH	ENSMMUP00000012018	ENSMMUP00000065431	Paired box 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.466
PAX2	SIX1	ENSMMUP00000012018	ENSMMUP00000076949	Paired box 2.	SIX homeobox 1.	0.678
PAX2	SIX4	ENSMMUP00000012018	ENSMMUP00000002189	Paired box 2.	SIX homeobox 4.	0.474
PAX2	WNT4	ENSMMUP00000012018	ENSMMUP00000068014	Paired box 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.481
PAX2	WT1	ENSMMUP00000012018	ENSMMUP00000012938	Paired box 2.	WT1 transcription factor.	0.692
PDGFRB	STAT1	ENSMMUP00000015166	ENSMMUP00000057114	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	Signal transducer and activator of transcription.	0.464
SHH	BMP7	ENSMMUP00000065431	ENSMMUP00000005446	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Bone morphogenetic protein 7.	0.519
SHH	PAX2	ENSMMUP00000065431	ENSMMUP00000012018	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Paired box 2.	0.466
SIX1	PAX2	ENSMMUP00000076949	ENSMMUP00000012018	SIX homeobox 1.	Paired box 2.	0.678
SIX1	WT1	ENSMMUP00000076949	ENSMMUP00000012938	SIX homeobox 1.	WT1 transcription factor.	0.533
SIX4	PAX2	ENSMMUP00000002189	ENSMMUP00000012018	SIX homeobox 4.	Paired box 2.	0.474