(60 nodes) Nephron tubule morphogenesis network (Macaca mulatta)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
	GZF1	GDNF inducible zinc finger protein 1. (819 aa)
	HS3ST3B1	Sulfotransferase; Belongs to the sulfotransferase 1 family. (390 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	IRX2	Iroquois homeobox 2. (500 aa)
	SIX1	SIX homeobox 1. (284 aa)
	TCF21	Transcription factor 21. (179 aa)
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
	BCL2	BCL2 apoptosis regulator. (241 aa)
	SOX8	SRY-box transcription factor 8. (617 aa)
	ADAMTS16	ADAM metallopeptidase with thrombospondin type 1 motif 16. (1275 aa)
	REX1BD	Uncharacterized protein. (657 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	GLI3	GLI family zinc finger 3. (1580 aa)
	BMP2	Bone morphogenetic protein 2. (396 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	WNT6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	KLHL3	BTB domain-containing protein. (612 aa)
	HOXA11	Homeobox A11. (311 aa)
	IRX1	Iroquois homeobox 1. (480 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	LZTS2	Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (669 aa)
	HES5	Uncharacterized protein. (166 aa)
	ENSMMUP00000062204	Uncharacterized protein. (81 aa)
	OSR1	Odd-skipped related transcription factor 1. (266 aa)
	PGF	Placental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
	HOXD11	Homeobox D11. (338 aa)
	FOXD1	Forkhead box D1. (468 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
	PTCH1	Patched 1. (1452 aa)
	KIF26B	Kinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2107 aa)
	GPC3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (603 aa)
	GREB1L	GREB1 like retinoic acid receptor coactivator. (1967 aa)
	DLG1	Disks large homolog 1 isoform 2; Belongs to the MAGUK family. (926 aa)
	LGR4	Leucine-rich repeat-containing G-protein coupled receptor 4. (951 aa)
	GREB1	Growth regulating estrogen receptor binding 1. (1949 aa)
	GDNF	Glial cell derived neurotrophic factor. (342 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	SALL1	Spalt like transcription factor 1. (1324 aa)
	WNK4	WNK lysine deficient protein kinase 4. (1242 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	HS2ST1	Heparan sulfate 2-O-sulfotransferase 1 isoform 1. (356 aa)
	COMMD5	COMM domain containing 5. (299 aa)
	PBX1	Pre-B-cell leukemia transcription factor 1 isoform 1. (430 aa)
	WT1	WT1 transcription factor. (517 aa)
	AHI1	Abelson helper integration site 1. (1196 aa)
	PAX2	Paired box 2. (418 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (969 aa)
	HS3ST3A1	Sulfotransferase; Belongs to the sulfotransferase 1 family. (406 aa)
	DCHS1	Dachsous cadherin-related 1. (3221 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
	GATA3	GATA binding protein 3. (444 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	HNF1B	Hepatocyte nuclear factor 1-beta. (557 aa)
	PKD1	Polycystin 1, transient receptor potential channel interacting. (4298 aa)
	FMN1	Formin 1. (1425 aa)
	IRX3	Iroquois homeobox 3. (501 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS16	IRX1	ENSMMUP00000069578	ENSMMUP00000063817	ADAM metallopeptidase with thrombospondin type 1 motif 16.	Iroquois homeobox 1.	0.440
ADAMTS16	IRX3	ENSMMUP00000069578	ENSMMUP00000001856	ADAM metallopeptidase with thrombospondin type 1 motif 16.	Iroquois homeobox 3.	0.483
BCL2	CTNNB1	ENSMMUP00000069881	ENSMMUP00000062910	BCL2 apoptosis regulator.	Catenin beta-1.	0.528
BCL2	FGF2	ENSMMUP00000069881	ENSMMUP00000009729	BCL2 apoptosis regulator.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.507
BCL2	SMAD4	ENSMMUP00000069881	ENSMMUP00000024106	BCL2 apoptosis regulator.	Mothers against decapentaplegic homolog.	0.443
BMP2	BMP4	ENSMMUP00000065891	ENSMMUP00000077296	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.940
BMP2	FGF1	ENSMMUP00000065891	ENSMMUP00000071478	Bone morphogenetic protein 2.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.525
BMP2	FGF2	ENSMMUP00000065891	ENSMMUP00000009729	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.733
BMP2	FGF8	ENSMMUP00000065891	ENSMMUP00000020713	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.592
BMP2	GPC3	ENSMMUP00000065891	ENSMMUP00000045159	Bone morphogenetic protein 2.	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.400
BMP2	NOG	ENSMMUP00000065891	ENSMMUP00000007646	Bone morphogenetic protein 2.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.997
BMP2	PTCH1	ENSMMUP00000065891	ENSMMUP00000051035	Bone morphogenetic protein 2.	Patched 1.	0.517
BMP2	SHH	ENSMMUP00000065891	ENSMMUP00000065431	Bone morphogenetic protein 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.481
BMP2	SMAD4	ENSMMUP00000065891	ENSMMUP00000024106	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.824
BMP2	SOX9	ENSMMUP00000065891	ENSMMUP00000073101	Bone morphogenetic protein 2.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.493
BMP2	WNT4	ENSMMUP00000065891	ENSMMUP00000068014	Bone morphogenetic protein 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.410
BMP4	BMP2	ENSMMUP00000077296	ENSMMUP00000065891	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.940
BMP4	CTNNB1	ENSMMUP00000077296	ENSMMUP00000062910	Bone morphogenetic protein 4.	Catenin beta-1.	0.402
BMP4	FGF1	ENSMMUP00000077296	ENSMMUP00000071478	Bone morphogenetic protein 4.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.578
BMP4	FGF2	ENSMMUP00000077296	ENSMMUP00000009729	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.787