(17 nodes) Nephron tubule formation network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IRX3	Iroquois homeobox 3. (501 aa)
	OSR1	Odd-skipped related transcription factor 1. (266 aa)
	IRX2	Iroquois homeobox 2. (500 aa)
	HES5	Uncharacterized protein. (166 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	IRX1	Iroquois homeobox 1. (480 aa)
	WNT6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	SOX8	SRY-box transcription factor 8. (617 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
	SIX1	SIX homeobox 1. (284 aa)
	GDNF	Glial cell derived neurotrophic factor. (342 aa)
	HS2ST1	Heparan sulfate 2-O-sulfotransferase 1 isoform 1. (356 aa)
	PAX2	Paired box 2. (418 aa)
	GATA3	GATA binding protein 3. (444 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	HNF1B	Hepatocyte nuclear factor 1-beta. (557 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTNNB1	SOX8	ENSMMUP00000062910	ENSMMUP00000069626	Catenin beta-1.	SRY-box transcription factor 8.	0.567
CTNNB1	SOX9	ENSMMUP00000062910	ENSMMUP00000073101	Catenin beta-1.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.778
CTNNB1	WNT6	ENSMMUP00000062910	ENSMMUP00000064654	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.556
CTNNB1	WNT9B	ENSMMUP00000062910	ENSMMUP00000070542	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.424
GDNF	NOG	ENSMMUP00000024951	ENSMMUP00000007646	Glial cell derived neurotrophic factor.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.522
HES5	SOX9	ENSMMUP00000062247	ENSMMUP00000073101	Uncharacterized protein.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.448
IRX1	IRX2	ENSMMUP00000063817	ENSMMUP00000077002	Iroquois homeobox 1.	Iroquois homeobox 2.	0.522
IRX1	SIX1	ENSMMUP00000063817	ENSMMUP00000076949	Iroquois homeobox 1.	SIX homeobox 1.	0.412
IRX2	IRX1	ENSMMUP00000077002	ENSMMUP00000063817	Iroquois homeobox 2.	Iroquois homeobox 1.	0.522
IRX2	IRX3	ENSMMUP00000077002	ENSMMUP00000001856	Iroquois homeobox 2.	Iroquois homeobox 3.	0.528
IRX3	IRX2	ENSMMUP00000001856	ENSMMUP00000077002	Iroquois homeobox 3.	Iroquois homeobox 2.	0.528
NOG	GDNF	ENSMMUP00000007646	ENSMMUP00000024951	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	Glial cell derived neurotrophic factor.	0.522
NOG	SOX9	ENSMMUP00000007646	ENSMMUP00000073101	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.452
OSR1	PAX2	ENSMMUP00000058804	ENSMMUP00000012018	Odd-skipped related transcription factor 1.	Paired box 2.	0.431
PAX2	OSR1	ENSMMUP00000012018	ENSMMUP00000058804	Paired box 2.	Odd-skipped related transcription factor 1.	0.431
PAX2	SIX1	ENSMMUP00000012018	ENSMMUP00000076949	Paired box 2.	SIX homeobox 1.	0.678
SIX1	IRX1	ENSMMUP00000076949	ENSMMUP00000063817	SIX homeobox 1.	Iroquois homeobox 1.	0.412
SIX1	PAX2	ENSMMUP00000076949	ENSMMUP00000012018	SIX homeobox 1.	Paired box 2.	0.678
SOX8	CTNNB1	ENSMMUP00000069626	ENSMMUP00000062910	SRY-box transcription factor 8.	Catenin beta-1.	0.567
SOX9	CTNNB1	ENSMMUP00000073101	ENSMMUP00000062910	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	Catenin beta-1.	0.778