STRINGSTRING
LEF1 LEF1 SMAD3 SMAD3 ACVRL1 ACVRL1 ACTA1 ACTA1 NOS3 NOS3 ACVR1 ACVR1 SMAD4 SMAD4 ACTA2 ACTA2 ACTG2 ACTG2 GATA5 GATA5 NOTCH1 NOTCH1 SNAI2 SNAI2 FGF8 FGF8 MDM2 MDM2 TBX20 TBX20 BMP5 BMP5 MDM4 MDM4 TGFBR2 TGFBR2 DCHS1 DCHS1 TAF10 TAF10 ACTC1 ACTC1 NOG NOG FOXC1 FOXC1 WNT3A WNT3A BMP7 BMP7 ROBO1 ROBO1 SMAD2 SMAD2 TBX2 TBX2 HNF1A HNF1A HEY1 HEY1 OSR1 OSR1 ROBO2 ROBO2 WNT11 WNT11 HEY2 HEY2 CPLANE2 CPLANE2 FOXF1 FOXF1 ISL1 ISL1 TGFB2 TGFB2 SNAI1 SNAI1 BMP2 BMP2 EXOC4 EXOC4 TMEM100 TMEM100 HEYL HEYL SOX9 SOX9 WNT5A WNT5A FOXC2 FOXC2 LOC721299 LOC721299 ENG ENG MSX1 MSX1 TBX3 TBX3 BMPR1A BMPR1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LEF1Lymphoid enhancer binding factor 1. (414 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
ACTA1Actin alpha 1, skeletal muscle. (377 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ACTA2Uncharacterized protein. (396 aa)
ACTG2Actin gamma 2, smooth muscle. (376 aa)
GATA5GATA binding protein 5. (397 aa)
NOTCH1Notch receptor 1. (2556 aa)
SNAI2Protein snail-like protein 2. (268 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
TBX20T-box transcription factor TBX20. (447 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (495 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
DCHS1Dachsous cadherin-related 1. (3221 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
ACTC1Actin alpha cardiac muscle 1. (377 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
FOXC1Forkhead box C1. (551 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
ROBO1Roundabout guidance receptor 1. (1691 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
TBX2T-box transcription factor 2. (712 aa)
HNF1AHNF1 homeobox A. (657 aa)
HEY1Hairy/enhancer-of-split related with YRPW motif protein 1 isoform a. (304 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
ROBO2Roundabout guidance receptor 2. (1394 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
CPLANE2Ciliogenesis and planar polarity effector 2. (258 aa)
FOXF1Forkhead box F1. (432 aa)
ISL1ISL LIM homeobox 1. (413 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
EXOC4Exocyst complex component 4 isoform a. (974 aa)
TMEM100Transmembrane protein 100. (134 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (477 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (462 aa)
FOXC2Forkhead box C2. (471 aa)
LOC721299Uncharacterized protein; Belongs to the actin family. (372 aa)
ENGEndoglin. (672 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
TBX3T-box transcription factor 3. (743 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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