(15 nodes) Cell differentiation involved in metanephros development network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	LGR4	Leucine-rich repeat-containing G-protein coupled receptor 4. (951 aa)
	SIX2	SIX homeobox 2. (292 aa)
	GDNF	Glial cell derived neurotrophic factor. (342 aa)
	SALL1	Spalt like transcription factor 1. (1324 aa)
	CD34	CD34 molecule. (385 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
	PAX2	Paired box 2. (418 aa)
	NPHS2	NPHS2 stomatin family member, podocin. (506 aa)
	OSR1	Odd-skipped related transcription factor 1. (266 aa)
	STAT1	Signal transducer and activator of transcription. (802 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (265 aa)
	LAMB2	Laminin subunit beta-2. (1798 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	TCF21	Transcription factor 21. (179 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	CD34	ENSMMUP00000077296	ENSMMUP00000019834	Bone morphogenetic protein 4.	CD34 molecule.	0.542
BMP4	GDNF	ENSMMUP00000077296	ENSMMUP00000024951	Bone morphogenetic protein 4.	Glial cell derived neurotrophic factor.	0.455
BMP4	PAX2	ENSMMUP00000077296	ENSMMUP00000012018	Bone morphogenetic protein 4.	Paired box 2.	0.400
BMP4	SMO	ENSMMUP00000077296	ENSMMUP00000015878	Bone morphogenetic protein 4.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.478
CD34	BMP4	ENSMMUP00000019834	ENSMMUP00000077296	CD34 molecule.	Bone morphogenetic protein 4.	0.542
GDNF	BMP4	ENSMMUP00000024951	ENSMMUP00000077296	Glial cell derived neurotrophic factor.	Bone morphogenetic protein 4.	0.455
NPHS2	PAX2	ENSMMUP00000005023	ENSMMUP00000012018	NPHS2 stomatin family member, podocin.	Paired box 2.	0.460
OSR1	PAX2	ENSMMUP00000058804	ENSMMUP00000012018	Odd-skipped related transcription factor 1.	Paired box 2.	0.431
PAX2	BMP4	ENSMMUP00000012018	ENSMMUP00000077296	Paired box 2.	Bone morphogenetic protein 4.	0.400
PAX2	NPHS2	ENSMMUP00000012018	ENSMMUP00000005023	Paired box 2.	NPHS2 stomatin family member, podocin.	0.460
PAX2	OSR1	ENSMMUP00000012018	ENSMMUP00000058804	Paired box 2.	Odd-skipped related transcription factor 1.	0.431
PAX2	SALL1	ENSMMUP00000012018	ENSMMUP00000022626	Paired box 2.	Spalt like transcription factor 1.	0.424
PAX2	SIX2	ENSMMUP00000012018	ENSMMUP00000031288	Paired box 2.	SIX homeobox 2.	0.612
PAX2	WNT4	ENSMMUP00000012018	ENSMMUP00000068014	Paired box 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.481
SALL1	PAX2	ENSMMUP00000022626	ENSMMUP00000012018	Spalt like transcription factor 1.	Paired box 2.	0.424
SALL1	SIX2	ENSMMUP00000022626	ENSMMUP00000031288	Spalt like transcription factor 1.	SIX homeobox 2.	0.603
SIX2	PAX2	ENSMMUP00000031288	ENSMMUP00000012018	SIX homeobox 2.	Paired box 2.	0.612
SIX2	SALL1	ENSMMUP00000031288	ENSMMUP00000022626	SIX homeobox 2.	Spalt like transcription factor 1.	0.603
SIX2	WNT4	ENSMMUP00000031288	ENSMMUP00000068014	SIX homeobox 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.442
SMO	BMP4	ENSMMUP00000015878	ENSMMUP00000077296	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	Bone morphogenetic protein 4.	0.478