STRINGSTRING
PKP2 PKP2 RYR2 RYR2 KCNE4 KCNE4 GJA1 GJA1 GJC1 GJC1 KCNJ3 KCNJ3 CACNB2 CACNB2 KCNQ1 KCNQ1 DMD DMD HCN2 HCN2 CACNA1C CACNA1C SLC8A1 SLC8A1 KCNIP2 KCNIP2 SCN5A SCN5A SCN10A SCN10A HCN4 HCN4 F6T365_MACMU F6T365_MACMU KCNH2 KCNH2 KCNA5 KCNA5 CACNA1G CACNA1G ANK2 ANK2 YWHAE YWHAE NUP155 NUP155 CACNA1D CACNA1D CACNA2D1 CACNA2D1 SCN1A SCN1A TRPM4 TRPM4 KCNN2 KCNN2 SCN1B SCN1B KCNJ5 KCNJ5 SCN2B SCN2B SCN4B SCN4B KCNE2 KCNE2 KCNE5 KCNE5 FGF12 FGF12 KCNJ8 KCNJ8 KCNE3 KCNE3 KCNJ2 KCNJ2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PKP2Plakophilin 2. (790 aa)
RYR2Ryanodine receptor 2. (4967 aa)
KCNE4Potassium voltage-gated channel subfamily E regulatory subunit 4. (170 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
GJC1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (396 aa)
KCNJ3G protein-activated inward rectifier potassium channel 1. (501 aa)
CACNB2SH3 domain-containing protein. (660 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (676 aa)
DMDUncharacterized protein. (3685 aa)
HCN2Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2. (888 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
SLC8A1J domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
KCNIP2Uncharacterized protein. (299 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2017 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1956 aa)
HCN4Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1203 aa)
F6T365_MACMU14_3_3 domain-containing protein. (74 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2. (1159 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (605 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2377 aa)
ANK2Ankyrin 2. (4045 aa)
YWHAE14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa)
NUP155Nucleoporin 155. (1449 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2008 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1215 aa)
KCNN2Potassium calcium-activated channel subfamily N member 2. (858 aa)
SCN1BSodium voltage-gated channel beta subunit 1. (402 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (469 aa)
SCN2BSodium voltage-gated channel beta subunit 2. (215 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (316 aa)
KCNE2Potassium voltage-gated channel subfamily E regulatory subunit 2. (123 aa)
KCNE5Potassium voltage-gated channel subfamily E regulatory subunit 5. (142 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
KCNJ8Potassium voltage-gated channel subfamily J member 8. (424 aa)
KCNE3Uncharacterized protein. (103 aa)
KCNJ2Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be bl [...] (427 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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