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| | SFRP4 | Secreted frizzled-related protein 4; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling. Has phosphaturic effects by specifically inhibiting sodium- dependent phosphate uptake. (346 aa) |
| | AMER2 | APC membrane recruitment protein 2. (550 aa) |
| | DKK4 | Dickkopf WNT signaling pathway inhibitor 4. (224 aa) |
| | PTPRO | Uncharacterized protein. (1216 aa) |
| | PRKN | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa) |
| | AMFR | Autocrine motility factor receptor. (643 aa) |
| | NKD2 | NKD inhibitor of WNT signaling pathway 2. (477 aa) |
| | CTHRC1 | Collagen triple helix repeat containing 1. (243 aa) |
| | LATS2 | Non-specific serine/threonine protein kinase. (1086 aa) |
| | WWTR1 | WW domain containing transcription regulator 1. (432 aa) |
| | RBMS3 | RNA binding motif single stranded interacting protein 3. (522 aa) |
| | CBY1 | Chibby family member 1, beta catenin antagonist. (268 aa) |
| | NOTCH1 | Notch receptor 1. (2556 aa) |
| | SOSTDC1 | Sclerostin domain containing 1. (206 aa) |
| | SNAI2 | Protein snail-like protein 2. (268 aa) |
| | DDIT3 | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (192 aa) |
| | APC | APC regulator of WNT signaling pathway. (2871 aa) |
| | CSNK1A1L | Casein kinase I isoform alpha-like protein; Belongs to the protein kinase superfamily. (337 aa) |
| | TNN | Tenascin N. (1299 aa) |
| | AXIN1 | Axin 1. (867 aa) |
| | DACT1 | Dishevelled binding antagonist of beta catenin 1. (837 aa) |
| | JADE1 | Uncharacterized protein. (858 aa) |
| | TLE6 | TLE family member 6, subcortical maternal complex member. (574 aa) |
| | FZD4 | Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa) |
| | AMER1 | APC membrane recruitment protein 1. (1136 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (462 aa) |
| | MLLT3 | MLLT3 super elongation complex subunit. (600 aa) |
| | AXIN2 | Axin 2. (862 aa) |
| | SOX9 | Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa) |
| | SFRP2 | Secreted frizzled-related protein 2. (295 aa) |
| | BICC1 | BicC family RNA binding protein 1. (1138 aa) |
| | PTPRU | Protein tyrosine phosphatase receptor type U. (1536 aa) |
| | SIAH2 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (324 aa) |
| | DKKL1 | Uncharacterized protein. (242 aa) |
| | G3BP1 | G3BP stress granule assembly factor 1. (546 aa) |
| | CAV1 | Caveolin 1. (303 aa) |
| | EMD | Emerin. (258 aa) |
| | MCC | MCC regulator of WNT signaling pathway. (1014 aa) |
| | STK4 | Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...] (487 aa) |
| | LMBR1L | Uncharacterized protein; Belongs to the LIMR family. (489 aa) |
| | UBAC2 | UBA domain-containing protein. (426 aa) |
| | CYLD | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa) |
| | FUZ | Fuzzy planar cell polarity protein. (445 aa) |
| | DKK1 | Dickkopf WNT signaling pathway inhibitor 1. (266 aa) |
| | TBX18 | T-box transcription factor 18. (556 aa) |
| | MESP1 | Mesoderm posterior bHLH transcription factor 1. (272 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa) |
| | IGFBP4 | Insulin-like growth factor-binding protein 4. (258 aa) |
| | TRIM2 | Transmembrane 131 like. (1724 aa) |
| | SOX13 | SRY-box 13. (621 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | TMEM88 | Transmembrane protein 88. (159 aa) |
| | LOC706619 | Uncharacterized protein. (805 aa) |
| | SCYL2 | SCY1-like protein 2. (929 aa) |
| | FZD6 | Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa) |
| | TLE2 | TLE family member 2, transcriptional corepressor. (844 aa) |
| | EGR1 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (545 aa) |
| | ANKRD6 | ANK_REP_REGION domain-containing protein. (827 aa) |
| | CSNK1A1 | Casein kinase I isoform alpha isoform 1; Belongs to the protein kinase superfamily. (365 aa) |
| | CCDC88C | Coiled-coil domain containing 88C. (2028 aa) |
| | INVS | Inversin. (1064 aa) |
| | SHISA6 | Shisa family member 6. (553 aa) |
| | IGFBP1 | Uncharacterized protein. (281 aa) |
| | LOC718731 | Dickkopf-like protein 1. (242 aa) |
| | NKX2-5 | NK2 homeobox 5. (324 aa) |
| | LATS1 | Large tumor suppressor kinase 1. (1224 aa) |
| | NOTUM | Notum, palmitoleoyl-protein carboxylesterase. (670 aa) |
| | SOST | Sclerostin. (213 aa) |
| | DRAXIN | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (349 aa) |
| | FRZB | Secreted frizzled-related protein 3. (325 aa) |
| | FRMD8 | FERM domain containing 8. (700 aa) |
| | NPHP4 | Nephrocystin 4. (1509 aa) |
| | DKK3 | Dickkopf-related protein 3. (350 aa) |
| | TCF7L2 | Transcription factor 7 like 2. (632 aa) |
| | STK11 | Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (433 aa) |
| | GLI1 | Zinc finger protein GLI1 isoform 1. (1106 aa) |
| | PFDN5 | Prefoldin subunit 5 isoform alpha. (154 aa) |
| | KREMEN1 | Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (492 aa) |
| | SFRP1 | Secreted frizzled-related protein 1. (314 aa) |
| | CHD8 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2581 aa) |
| | DAB2 | Differentially-expressed protein 2. (770 aa) |
| | FOXO1 | Forkhead box O1. (655 aa) |
| | LRP4 | Low-density lipoprotein receptor-related protein 4. (1905 aa) |
| | CTNND1 | Uncharacterized protein. (968 aa) |
| | FERMT1 | Fermitin family member 1. (677 aa) |
| | PRICKLE1 | Prickle planar cell polarity protein 1. (848 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (212 aa) |
| | TLE1 | TLE family member 1, transcriptional corepressor. (804 aa) |
| | DACT3 | Dishevelled binding antagonist of beta catenin 3. (631 aa) |
| | TLE3 | TLE family member 3, transcriptional corepressor. (901 aa) |
| | HECW1 | E3 ubiquitin-protein ligase HECW1. (1606 aa) |
| | TPBGL | Trophoblast glycoprotein like. (384 aa) |
| | OTUD5 | OTU deubiquitinase 5. (566 aa) |
| | STK3 | Uncharacterized protein. (519 aa) |
| | APOE | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa) |
| | TMEM64 | Transmembrane protein 64. (389 aa) |
| | APC2 | APC regulator of WNT signaling pathway 2. (2403 aa) |
| | RBX1 | E3 ubiquitin-protein ligase RBX1. (108 aa) |
| | MDK | Midkine. (143 aa) |
| | ENSMMUP00000059946 | Protein kinase domain-containing protein. (224 aa) |
| | GSK3B | Glycogen synthase kinase-3 beta isoform 1; Belongs to the protein kinase superfamily. (433 aa) |
| | SHISA3 | Shisa family member 3. (238 aa) |
| | ENSMMUP00000062204 | Uncharacterized protein. (81 aa) |
| | LZTS2 | Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (669 aa) |
| | WNT11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa) |
| | CTNNB1 | Catenin beta-1. (781 aa) |
| | SFRP5 | Secreted frizzled related protein 5. (449 aa) |
| | ENSMMUP00000063403 | Uncharacterized protein. (81 aa) |
| | SDHAF2 | Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (166 aa) |
| | ISL1 | ISL LIM homeobox 1. (413 aa) |
| | NKD1 | NKD inhibitor of WNT signaling pathway 1. (499 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa) |
| | SOX10 | SRY-box transcription factor 10. (467 aa) |
| | BMP2 | Bone morphogenetic protein 2. (396 aa) |
| | LIMD1 | LIM domains containing 1. (676 aa) |
| | SOX17 | SRY-box transcription factor 17. (414 aa) |
| | DAB2IP | DAB2 interacting protein. (1162 aa) |
| | IGFBP2 | Insulin like growth factor binding protein 2. (325 aa) |
| | GLI3 | GLI family zinc finger 3. (1580 aa) |
| | TLE7 | TLE family member 7. (441 aa) |
| | TMEM170B | Transmembrane protein 170B. (132 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (497 aa) |
| | DKK2 | Uncharacterized protein. (259 aa) |
| | NPPA | Natriuretic peptide A. (153 aa) |
| | NOG | Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa) |
