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| | HTRA4 | HtrA serine peptidase 4. (475 aa) |
| | SORL1 | Sortilin related receptor 1. (2214 aa) |
| | FOXD1 | Forkhead box D1. (468 aa) |
| | CAV3 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (196 aa) |
| | PPM1A | Protein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa) |
| | BCL9L | BCL9 like. (1500 aa) |
| | CRIM1 | Cysteine rich transmembrane BMP regulator 1. (1036 aa) |
| | SOX11 | Transcription factor SOX. (441 aa) |
| | KIAA1324L | UPF0577 protein KIAA1324-like isoform 1. (1029 aa) |
| | PBLD | Uncharacterized protein. (519 aa) |
| | SPRED2 | Uncharacterized protein. (419 aa) |
| | HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa) |
| | FKBP8 | Peptidylprolyl isomerase. (441 aa) |
| | RGMA | Repulsive guidance molecule BMP co-receptor a. (576 aa) |
| | CDKN1C | Cyclin dependent kinase inhibitor 1C. (332 aa) |
| | TGFBR3L | Transforming growth factor beta receptor 3 like. (312 aa) |
| | SDCBP | Syndecan binding protein. (324 aa) |
| | NUP93 | Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family. (819 aa) |
| | BMP8B | TGF_BETA_2 domain-containing protein. (402 aa) |
| | VASN | Vasorin. (790 aa) |
| | DAND5 | DAN domain BMP antagonist family member 5. (116 aa) |
| | MYOCD | Myocardin. (986 aa) |
| | CCN1 | Cellular communication network factor 1. (381 aa) |
| | UBE2O | Ubiquitin-conjugating enzyme E2 O. (1293 aa) |
| | HFE | Homeostatic iron regulator; Belongs to the MHC class I family. (348 aa) |
| | HOXA13 | Homeobox A13. (226 aa) |
| | CAV1 | Caveolin 1. (303 aa) |
| | MSTN | Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. (375 aa) |
| | JAK2 | Tyrosine-protein kinase. (1137 aa) |
| | DNM2 | Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (880 aa) |
| | BMP10 | Bone morphogenetic protein 10. (424 aa) |
| | ING1 | Inhibitor of growth protein. (279 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | SFRP2 | Secreted frizzled-related protein 2. (295 aa) |
| | BRMS1 | BRMS1 transcriptional repressor and anoikis regulator. (280 aa) |
| | HJV | Hemojuvelin BMP co-receptor. (427 aa) |
| | PPARA | Peroxisome proliferator activated receptor alpha. (467 aa) |
| | CTDSPL2 | CTD small phosphatase-like protein 2. (466 aa) |
| | SOSTDC1 | Sclerostin domain containing 1. (206 aa) |
| | LEMD3 | Inner nuclear membrane protein Man1 isoform 1. (909 aa) |
| | NOTCH1 | Notch receptor 1. (2556 aa) |
| | CHST11 | Carbohydrate sulfotransferase. (352 aa) |
| | BMPER | BMP binding endothelial regulator. (685 aa) |
| | RNF165 | Ring finger protein 165. (346 aa) |
| | CD109 | CD109 molecule. (1364 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | ACVR1 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa) |
| | ACVR2B | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa) |
| | LATS2 | Non-specific serine/threonine protein kinase. (1086 aa) |
| | GATA4 | GATA binding protein 4. (443 aa) |
| | KIAA0319 | KIAA0319. (1072 aa) |
| | CISD1 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (210 aa) |
| | LTBP4 | Latent transforming growth factor beta binding protein 4. (1624 aa) |
| | SFRP4 | Secreted frizzled-related protein 4; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling. Has phosphaturic effects by specifically inhibiting sodium- dependent phosphate uptake. (346 aa) |
| | SAP130 | Sin3A associated protein 130. (1083 aa) |
| | MPP5 | Membrane palmitoylated protein 5; Belongs to the MAGUK family. (663 aa) |
| | LTBP1 | Latent transforming growth factor beta binding protein 1. (1720 aa) |
| | BMP6 | Bone morphogenetic protein 6. (511 aa) |
| | NRROS | Negative regulator of reactive oxygen species. (732 aa) |
| | LEMD2 | LEM domain containing 2. (548 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa) |
| | WFIKKN1 | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (548 aa) |
| | STK11 | Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (433 aa) |
| | HTRA3 | Putative serine protease HTRA3. (453 aa) |
| | WFIKKN2 | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (576 aa) |
| | VEPH1 | Ventricular zone expressed PH domain containing 1. (833 aa) |
| | DKK3 | Dickkopf-related protein 3. (350 aa) |
| | SPRED3 | Sprouty related EVH1 domain containing 3. (412 aa) |
| | NODAL | Nodal growth differentiation factor. (347 aa) |
| | ONECUT2 | One cut domain family member. (505 aa) |
| | SULF1 | Sulfatase 1. (1120 aa) |
| | LRG1 | Leucine rich alpha-2-glycoprotein 1. (383 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | SFRP1 | Secreted frizzled-related protein 1. (314 aa) |
| | GDF2 | Growth differentiation factor 2. (429 aa) |
| | HES5 | Uncharacterized protein. (166 aa) |
| | VWC2L | VWFC domain-containing protein. (222 aa) |
| | ZBTB7A | Zinc finger and BTB domain containing 7A. (692 aa) |
| | MTMR4 | Uncharacterized protein. (1209 aa) |
| | CDH5 | Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (785 aa) |
| | ZNF451 | Zinc finger protein 451 isoform 1. (1061 aa) |
| | RNF111 | Ring finger protein 111. (1041 aa) |
| | SFRP5 | Secreted frizzled related protein 5. (449 aa) |
| | SPRY1 | Uncharacterized protein. (343 aa) |
| | SMAD7 | Mothers against decapentaplegic homolog. (462 aa) |
| | CIDEA | Cell death inducing DFFA like effector a. (219 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | GDF6 | Growth differentiation factor 6. (455 aa) |
| | OGT | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 1. (1046 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa) |
| | SCUBE3 | Signal peptide, CUB domain and EGF like domain containing 3. (1009 aa) |
| | FBXL15 | F-box domain-containing protein. (361 aa) |
| | BMP15 | TGF_BETA_2 domain-containing protein. (393 aa) |
| | CREBBP | CREB-binding protein isoform a. (2442 aa) |
| | SLC2A10 | Solute carrier family 2 member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (624 aa) |
| | BMP2 | Bone morphogenetic protein 2. (396 aa) |
| | C10H20orf27 | Chromosome 10 C20orf27 homolog. (296 aa) |
| | GDF5 | Growth differentiation factor 5. (499 aa) |
| | ADAM17 | Disintegrin and metalloproteinase domain-containing protein 17 preproprotein. (824 aa) |
| | KDR | Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa) |
| | NKX2-1 | NK2 homeobox 1. (448 aa) |
| | DLX1 | Homeobox protein DLX-1 isoform 1. (255 aa) |
| | GREM2 | Gremlin. (168 aa) |
| | TRIM33 | Tripartite motif containing 33. (1112 aa) |
| | CILP | Cartilage intermediate layer protein 1. (1184 aa) |
| | SPRY2 | Sprouty RTK signaling antagonist 2. (315 aa) |
| | TBX20 | T-box transcription factor TBX20. (447 aa) |
| | CER1 | Cerberus-related protein. (267 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | GDF10 | Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa) |
| | BMP5 | Bone morphogenetic protein 5. (454 aa) |
| | PCSK6 | Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (966 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (557 aa) |
| | F7B371_MACMU | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (313 aa) |
| | CILP2 | Cartilage intermediate layer protein 2. (1156 aa) |
| | TNFAIP6 | Tumor necrosis factor-inducible gene 6 protein. (277 aa) |
| | DKK1 | Dickkopf WNT signaling pathway inhibitor 1. (266 aa) |
| | FBN2 | Fibrillin 2. (2912 aa) |
| | BRMS1L | Breast cancer metastasis-suppressor 1-like protein. (323 aa) |
| | SAP30L | Histone deacetylase complex subunit SAP30L isoform 1. (184 aa) |
| | BMP3 | Bone morphogenetic protein 3; Belongs to the TGF-beta family. (474 aa) |
| | SKI | SKI proto-oncogene. (730 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa) |
| | FGF9 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | NEO1 | Neogenin 1. (1465 aa) |
| | SIN3A | SIN3 transcription regulator family member A. (1273 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa) |
| | ING2 | Inhibitor of growth protein. (280 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa) |
| | CHRD | Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (955 aa) |
| | LOC718677 | TGF_BETA_2 domain-containing protein. (402 aa) |
| | INHA | Inhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (366 aa) |
| | XBP1 | X-box binding protein 1. (376 aa) |
| | ARID4B | AT-rich interaction domain 4B. (1318 aa) |
| | SKOR1 | SKI family transcriptional corepressor 1. (964 aa) |
| | IL17F | Interleukin-17F. (163 aa) |
| | CRB2 | Crumbs cell polarity complex component 2. (1287 aa) |
| | KCP | Kielin cysteine rich BMP regulator. (1630 aa) |
| | GDF11 | Growth differentiation factor 11. (408 aa) |
| | DAB2 | Differentially-expressed protein 2. (770 aa) |
| | SIRT1 | Sirtuin 1. (743 aa) |
| | ZEB1 | Zinc finger E-box binding homeobox 1. (1126 aa) |
| | CHRDL2 | Chordin like 2. (430 aa) |
| | MEN1 | Menin isoform 2. (610 aa) |
| | FERMT1 | Fermitin family member 1. (677 aa) |
| | FAM89B | Uncharacterized protein. (176 aa) |
| | IL17RD | Interleukin 17 receptor D. (739 aa) |
| | ACVRL1 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa) |
| | ADAMTSL2 | ADAMTS like 2. (958 aa) |
| | EID2 | EP300-interacting inhibitor of differentiation 2. (236 aa) |
| | PRDM16 | PR/SET domain 16. (1276 aa) |
| | IGSF1 | Immunoglobulin superfamily member 1. (1354 aa) |
| | CHRDL1 | Chordin-like protein 1 isoform 1. (458 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (425 aa) |
| | GLG1 | Golgi glycoprotein 1. (1212 aa) |
| | STUB1 | STIP1 homology and U-box containing protein 1. (539 aa) |
| | CITED4 | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4. (232 aa) |
| | SMAD6 | Mothers against decapentaplegic homolog. (496 aa) |
| | TET1 | Tet methylcytosine dioxygenase 1. (2132 aa) |
| | LOC714226 | Uncharacterized protein. (1222 aa) |
| | SMAD2 | Mothers against decapentaplegic homolog. (467 aa) |
| | FSTL1 | Uncharacterized protein. (327 aa) |
| | SNX25 | Sorting nexin 25. (879 aa) |
| | NOTCH2 | Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa) |
| | STRAP | Serine-threonine kinase receptor-associated protein. (350 aa) |
| | TGFB1I1 | Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (485 aa) |
| | ZEB2 | Zinc finger E-box binding homeobox 2. (1213 aa) |
| | SPINT3 | Serine peptidase inhibitor, Kunitz type 3. (89 aa) |
| | SKOR2 | SKI family transcriptional corepressor 2. (1013 aa) |
| | CITED2 | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa) |
| | SNW1 | SNW domain-containing protein 1. (536 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa) |
| | MAGI2 | Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1452 aa) |
| | ACVR1B | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa) |
| | PYCR2 | Left-right determination factor. (364 aa) |
| | UBL3 | Ubiquitin-like protein. (117 aa) |
| | PEG10 | Paternally expressed 10. (401 aa) |
| | VWC2 | Von Willebrand factor C domain containing 2. (325 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | ABL1 | Tyrosine-protein kinase. (1149 aa) |
| | LRP1 | LDL receptor related protein 1. (4561 aa) |
| | PMEPA1 | Prostate transmembrane protein, androgen induced 1. (287 aa) |
| | FSTL3 | Uncharacterized protein. (436 aa) |
| | BMPR1A | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa) |
| | TFAP2B | Transcription factor AP-2 beta. (504 aa) |
| | SKIL | SKI like proto-oncogene. (693 aa) |
| | GIPC2 | PDZ domain-containing protein. (319 aa) |
| | RBPMS | RNA binding protein, mRNA processing factor. (224 aa) |
| | INHBB | Inhibin subunit beta B. (407 aa) |
| | GDF7 | Growth differentiation factor 7. (539 aa) |
| | ZC3H3 | Zinc finger CCCH-type containing 3. (1144 aa) |
| | LRP2 | LDL receptor related protein 2. (4660 aa) |
| | SPART | Spartin. (666 aa) |
| | MSX1 | Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa) |
| | BMP4 | Bone morphogenetic protein 4. (408 aa) |
| | INHBA | Inhibin subunit beta A. (426 aa) |
| | ITGA8 | Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa) |
| | EP300 | Histone acetyltransferase p300. (2414 aa) |
| | ENG | Endoglin. (672 aa) |
| | KHK | Elastin microfibril interfacer 1. (1016 aa) |
| | HTRA1 | Serine protease HTRA1. (481 aa) |
| | LOC703641 | CTCK domain-containing protein. (408 aa) |
| | SMURF2 | E3 ubiquitin-protein ligase. (748 aa) |
| | FLCN | UDENN FLCN/SMCR8-type domain-containing protein. (680 aa) |
| | LDLRAD4 | Uncharacterized protein. (306 aa) |
| | SLC29A1 | HATPase_c domain-containing protein. (1077 aa) |
| | PIN1 | Peptidyl-prolyl cis-trans isomerase. (163 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (462 aa) |
| | TWSG1 | Twisted gastrulation protein-like protein 1. (223 aa) |
| | GATA6 | Transcription factor GATA-6. (595 aa) |
| | ZNF423 | Zinc finger protein 423. (1356 aa) |
| | GDF3 | Growth differentiation factor 3. (364 aa) |
| | LOX | Lysyl oxidase. (417 aa) |
| | SPRED1 | Sprouty-related, EVH1 domain-containing protein 1. (444 aa) |
| | LATS1 | Large tumor suppressor kinase 1. (1224 aa) |
| | ACVR2A | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa) |
| | LINGO3 | Ig-like domain-containing protein. (592 aa) |
| | SOST | Sclerostin. (213 aa) |
| | NUMA1 | Nuclear mitotic apparatus protein 1. (2154 aa) |
| | GIPC3 | PDZ domain-containing protein. (1440 aa) |
| | BAMBI | BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa) |
| | SMURF1 | E3 ubiquitin-protein ligase. (757 aa) |
| | TMPRSS6 | Transmembrane serine protease 6. (970 aa) |
| | ITGA3 | Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1064 aa) |
| | AXIN1 | Axin 1. (867 aa) |
| | INHBC | TGF_BETA_2 domain-containing protein. (356 aa) |
| | CDKN2B | Cyclin dependent kinase inhibitor 2B. (158 aa) |
| | ZNF703 | Zinc finger protein 703. (591 aa) |
| | TGFBR3 | Transforming growth factor beta receptor 3. (860 aa) |
| | PELO | Protein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa) |
| | GREM1 | Gremlin-1; Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (By similarity). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity). (240 aa) |
| | SAP30 | Histone deacetylase complex subunit SAP30. (220 aa) |
| | HIPK2 | Homeodomain interacting protein kinase 2. (1212 aa) |
| | NREP | Uncharacterized protein. (112 aa) |
| | ARID4A | AT-rich interactive domain-containing protein 4A isoform I. (1257 aa) |
| | BMP7 | Bone morphogenetic protein 7. (431 aa) |
| | DACT2 | Dishevelled binding antagonist of beta catenin 2. (923 aa) |
| | FBN1 | Fibrillin-1. (2871 aa) |
| | ASPN | Asporin. (374 aa) |
| | FST | Follistatin. (344 aa) |
| | HSPA5 | 78 kDa glucose-regulated protein; Belongs to the heat shock protein 70 family. (654 aa) |
| | UCMA | Upper zone of growth plate and cartilage matrix associated. (136 aa) |
| | CCN3 | Cellular communication network factor 3. (357 aa) |
| | GIPC1 | PDZ domain-containing protein GIPC1 isoform 1. (333 aa) |
| | LOC699676 | Left-right determination factor. (366 aa) |
| | NOG | Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa) |
| | THBS1 | Thrombospondin 1. (1170 aa) |
