STRINGSTRING
ITGA3 ITGA3 ITGA4 ITGA4 IL23R IL23R IL12RB2 IL12RB2 ITGA1 ITGA1 IL6ST IL6ST GPR156 GPR156 TFRC TFRC RAMP2 RAMP2 GRID2 GRID2 ITGA6 ITGA6 TLR6 TLR6 TRAT1 TRAT1 GP1BA GP1BA ITGB3 ITGB3 CD8A CD8A CD40 CD40 ACVR1C ACVR1C ITGA5 ITGA5 CHRNA10 CHRNA10 ITGA11 ITGA11 GRIA4 GRIA4 ITGB7 ITGB7 GRIN2D GRIN2D ABHD6 ABHD6 OLFM3 OLFM3 ITGB8 ITGB8 HTR3B HTR3B CHRNB4 CHRNB4 CACNG7 CACNG7 TF TF GRIA3 GRIA3 IL18R1 IL18R1 TGFBR2 TGFBR2 PTPN6 PTPN6 CHRNA5 CHRNA5 IFNL1 IFNL1 TRAF2 TRAF2 TGFB3 TGFB3 IL12RB1 IL12RB1 IGF1R IGF1R ITGA2B ITGA2B ITGA7 ITGA7 CACNG3 CACNG3 FLNA FLNA SHISA9 SHISA9 HTR3C HTR3C CALCR CALCR JAK2 JAK2 SHISA8 SHISA8 CHRNA4 CHRNA4 ITGA10 ITGA10 HJV HJV GRIN3A GRIN3A CSF2 CSF2 STXBP5 STXBP5 GRIK5 GRIK5 CD3D CD3D CHRNB1 CHRNB1 ITGB1 ITGB1 TRAF6 TRAF6 ACVR1 ACVR1 ACVR2B ACVR2B GRIN2B GRIN2B PTK2B PTK2B ITGAV ITGAV EPS8 EPS8 CNTFR CNTFR ZAP70 ZAP70 ITGB4 ITGB4 CHRNA1 CHRNA1 CHRNG CHRNG CHRNA7 CHRNA7 IL6R IL6R IFNLR1 IFNLR1 TGFB1 TGFB1 CHRNA3 CHRNA3 IKBKB IKBKB ITGAL ITGAL GABBR1 GABBR1 HFE HFE CHRNA9 CHRNA9 ITGAE ITGAE IL18RAP IL18RAP CACNG2 CACNG2 ABHD12 ABHD12 TRAF5 TRAF5 LOC719678 LOC719678 IL23A IL23A GRIN1 GRIN1 DLG3 DLG3 GP1BB GP1BB CHUK CHUK IRS1 IRS1 GRIK2 GRIK2 OLFM2 OLFM2 INSR INSR CACNG8 CACNG8 GRIN2A GRIN2A CHRNA6 CHRNA6 BMPR1B BMPR1B CSF2RB CSF2RB CHRND CHRND IL6 IL6 TFR2 TFR2 ERBB3 ERBB3 GRIN3B GRIN3B TGFBR1 TGFBR1 ITGAM ITGAM LYN LYN ACVR1B ACVR1B CD79B CD79B HTR3D HTR3D ITGA2 ITGA2 VWC2 VWC2 ITGB6 ITGB6 CD3G CD3G PGBD4 PGBD4 GRIK4 GRIK4 CD79A CD79A IL27RA IL27RA CHRNA2 CHRNA2 HTR3E HTR3E CNIH2 CNIH2 CD247 CD247 SDCBP SDCBP GRIA1 GRIA1 GRIA2 GRIA2 VWC2L VWC2L CD3E CD3E GABBR2 GABBR2 GP9 GP9 SYK SYK ITGB5 ITGB5 ERBB2 ERBB2 INSRR INSRR CACNG5 CACNG5 BMP2 BMP2 ENSMMUP00000066266 ENSMMUP00000066266 TRAF3 TRAF3 TYK2 TYK2 HTR3A HTR3A CHRNE CHRNE PORCN PORCN DLG4 DLG4 ENSMMUP00000068605 ENSMMUP00000068605 ITGAX ITGAX CACNG4 CACNG4 RAMP3 RAMP3 APBB1IP APBB1IP RAMP1 RAMP1 ACVR2A ACVR2A GRIN2C GRIN2C PMP22 PMP22 OSMR OSMR CPT1C CPT1C HTRA2 HTRA2 ENSMMUP00000073505 ENSMMUP00000073505 CNIH3 CNIH3 ITGB2 ITGB2 BIRC2 BIRC2 AMHR2 AMHR2 RNF31 RNF31 CALCRL CALCRL B2M B2M KHK KHK SKAP1 SKAP1 ITGA8 ITGA8 ITGA9 ITGA9 TLR1 TLR1 IL13RA1 IL13RA1 SHISA6 SHISA6 BMPR1A BMPR1A LIME1 LIME1 SHISA7 SHISA7 CHRNB2 CHRNB2 GRM1 GRM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1064 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
IL23RInterleukin 23 receptor. (629 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (863 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1174 aa)
IL6STUncharacterized protein. (942 aa)
GPR156G protein-coupled receptor 156. (814 aa)
TFRCTransferrin receptor protein 1. (760 aa)
RAMP2Receptor activity-modifying protein 2. (175 aa)
GRID2Glutamate ionotropic receptor delta type subunit 2. (1007 aa)
ITGA6Integrin alpha-6 isoform a; Belongs to the integrin alpha chain family. (1091 aa)
TLR6Toll-like receptor. (796 aa)
TRAT1T cell receptor associated transmembrane adaptor 1. (187 aa)
GP1BAGlycoprotein Ib platelet subunit alpha. (754 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (741 aa)
CD8ACD8a molecule. (269 aa)
CD40Tumor necrosis factor receptor superfamily member 5 isoform 1. (278 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1049 aa)
CHRNA10Cholinergic receptor nicotinic alpha 10 subunit. (450 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1188 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (884 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (807 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (1336 aa)
ABHD6Abhydrolase domain containing 6. (337 aa)
OLFM3Olfactomedin-like domain-containing protein. (478 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (822 aa)
HTR3B5-hydroxytryptamine receptor 3B; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (441 aa)
CHRNB4Cholinergic receptor nicotinic beta 4 subunit. (492 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
TFTransferrin; Belongs to the transferrin family. (698 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
IL18R1Interleukin 18 receptor 1. (540 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (626 aa)
CHRNA5Cholinergic receptor nicotinic alpha 5 subunit. (468 aa)
IFNL1Interferon lambda 1. (202 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (513 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (789 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1090 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1141 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
FLNAFilamin-A isoform 2. (2647 aa)
SHISA9Shisa family member 9. (424 aa)
HTR3C5-hydroxytryptamine receptor 3C; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (432 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (517 aa)
JAK2Tyrosine-protein kinase. (1137 aa)
SHISA8Shisa family member 8. (398 aa)
CHRNA4Uncharacterized protein. (625 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1167 aa)
HJVHemojuvelin BMP co-receptor. (427 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1115 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (144 aa)
STXBP5Syntaxin binding protein 5. (1152 aa)
GRIK5Glutamate ionotropic receptor kainate type subunit 5. (1388 aa)
CD3DIg_4 domain-containing protein. (171 aa)
CHRNB1Cholinergic receptor nicotinic beta 1 subunit. (501 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
TRAF6TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
ITGAVIntegrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1051 aa)
EPS8SH3 domain-containing protein. (833 aa)
CNTFRUncharacterized protein. (402 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
ITGB4Integrin beta. (1823 aa)
CHRNA1Cholinergic receptor nicotinic alpha 1 subunit. (502 aa)
CHRNGCholinergic receptor nicotinic gamma subunit. (516 aa)
CHRNA7Neuronal acetylcholine receptor subunit alpha-7; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin (By similarity). (502 aa)
IL6RInterleukin 6 receptor. (536 aa)
IFNLR1Interferon lambda receptor 1. (526 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CHRNA3Cholinergic receptor nicotinic alpha 3 subunit. (497 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform 1. (756 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1169 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (962 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (348 aa)
CHRNA9Cholinergic receptor nicotinic alpha 9 subunit. (479 aa)
ITGAEIntegrin subunit alpha E; Belongs to the integrin alpha chain family. (1197 aa)
IL18RAPInterleukin 18 receptor accessory protein. (598 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
ABHD12Monoacylglycerol lipase ABHD12 isoform a. (398 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
LOC719678Uncharacterized protein. (626 aa)
IL23AInterleukin-23 subunit alpha. (189 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (943 aa)
DLG3Uncharacterized protein; Belongs to the MAGUK family. (867 aa)
GP1BBGlycoprotein Ib platelet subunit beta. (208 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
IRS1Insulin receptor substrate 1. (1253 aa)
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (908 aa)
OLFM2Olfactomedin-like domain-containing protein. (478 aa)
INSRInsulin receptor subunit alpha; Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lea [...] (1279 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (387 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
CHRNA6Cholinergic receptor nicotinic alpha 6 subunit. (494 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
CSF2RBColony stimulating factor 2 receptor beta common subunit. (898 aa)
CHRNDCholinergic receptor nicotinic delta subunit. (573 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (266 aa)
TFR2Transferrin receptor 2. (829 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3 isoform 1. (1342 aa)
GRIN3BGlutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1042 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1271 aa)
LYNTyrosine-protein kinase. (577 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
CD79BB-cell antigen receptor complex-associated protein beta chain isoform 3. (231 aa)
HTR3D5-hydroxytryptamine receptor 3D. (440 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1180 aa)
VWC2Von Willebrand factor C domain containing 2. (325 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
CD3GCD3g molecule. (209 aa)
PGBD4PiggyBac transposable element derived 4. (583 aa)
GRIK4Glutamate ionotropic receptor kainate type subunit 4. (956 aa)
CD79ACD79a molecule. (225 aa)
IL27RAInterleukin 27 receptor subunit alpha. (641 aa)
CHRNA2Cholinergic receptor nicotinic alpha 2 subunit. (530 aa)
HTR3E5-hydroxytryptamine receptor 3E; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (420 aa)
CNIH2Cornichon family AMPA receptor auxiliary protein 2. (160 aa)
CD247CD247 molecule. (224 aa)
SDCBPSyndecan binding protein. (324 aa)
GRIA1Uncharacterized protein. (916 aa)
GRIA2Uncharacterized protein. (883 aa)
VWC2LVWFC domain-containing protein. (222 aa)
CD3ECD3e molecule. (217 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (941 aa)
GP9Uncharacterized protein. (246 aa)
SYKTyrosine-protein kinase. (635 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
ERBB2Receptor protein-tyrosine kinase. (1437 aa)
INSRRTyrosine-protein kinase receptor. (1301 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (275 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
ENSMMUP00000066266Uncharacterized protein. (188 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
TYK2Tyrosine-protein kinase. (1196 aa)
HTR3A5-hydroxytryptamine receptor 3A; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (485 aa)
CHRNECholinergic receptor nicotinic epsilon subunit. (493 aa)
PORCNPorcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (570 aa)
DLG4Uncharacterized protein; Belongs to the MAGUK family. (972 aa)
ENSMMUP00000068605Uncharacterized protein. (107 aa)
ITGAXIntegrin subunit alpha X; Belongs to the integrin alpha chain family. (1184 aa)
CACNG4Uncharacterized protein. (657 aa)
RAMP3Uncharacterized protein. (172 aa)
APBB1IPAmyloid beta precursor protein binding family B member 1 interacting protein. (674 aa)
RAMP1Uncharacterized protein. (204 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (1317 aa)
PMP22Peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system; Belongs to the PMP-22/EMP/MP20 family. (160 aa)
OSMROncostatin M receptor. (977 aa)
CPT1CCarnitine palmitoyltransferase 1C. (876 aa)
HTRA2Serine protease HTRA2, mitochondrial isoform 1 preproprotein. (458 aa)
ENSMMUP00000073505Uncharacterized protein. (391 aa)
CNIH3Cornichon family AMPA receptor auxiliary protein 3. (183 aa)
ITGB2Integrin beta. (911 aa)
BIRC2Baculoviral IAP repeat-containing protein 2. (618 aa)
AMHR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (584 aa)
RNF31Uncharacterized protein. (1146 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (472 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (119 aa)
KHKElastin microfibril interfacer 1. (1016 aa)
SKAP1Src kinase associated phosphoprotein 1. (457 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)
ITGA9Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1040 aa)
TLR1Toll-like receptor. (786 aa)
IL13RA1Uncharacterized protein. (437 aa)
SHISA6Shisa family member 6. (553 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
LIME1Uncharacterized protein. (315 aa)
SHISA7Shisa family member 7. (659 aa)
CHRNB2Neuronal acetylcholine receptor subunit beta-2. (502 aa)
GRM1Metabotropic glutamate receptor 1 isoform alpha. (1195 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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