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DRD2 DRD2 SYT9 SYT9 STX4 STX4 IL13RA2 IL13RA2 GIPC2 GIPC2 LOC114675624 LOC114675624 SYT12 SYT12 NCKAP1L NCKAP1L PREPL PREPL PFN1 PFN1 SYNPR SYNPR DTNBP1 DTNBP1 PRAM1 PRAM1 ITGB2 ITGB2 SNAPIN SNAPIN RAB27A RAB27A FBXL20 FBXL20 RIMS3 RIMS3 PLA2G3 PLA2G3 GIPC3 GIPC3 SYN1 SYN1 RAP1A RAP1A CNR1 CNR1 ADCY1 ADCY1 LOC721699 LOC721699 IL4R IL4R PFN2 PFN2 DOC2A DOC2A SYT3 SYT3 FGR FGR SYP SYP CHRM2 CHRM2 SYT2 SYT2 RAB3D-2 RAB3D-2 SYK SYK FOXF1 FOXF1 CEACAM1 CEACAM1 PRKCB PRKCB ADORA2B ADORA2B RIMS4 RIMS4 GSK3B GSK3B GAB2 GAB2 CD160 CD160 FMR1 FMR1 STXBP2 STXBP2 ENSMMUP00000057803 ENSMMUP00000057803 GIT1 GIT1 CACNA1H CACNA1H SYT6 SYT6 RAC2 RAC2 ADRA1A ADRA1A SYT11 SYT11 APBA1 APBA1 RPH3AL RPH3AL CBARP CBARP LYN LYN ITGAM ITGAM SYT7 SYT7 CASK CASK RAB3GAP1 RAB3GAP1 FES FES KLRC2 KLRC2 SYT5 SYT5 RABGEF1 RABGEF1 DGKI DGKI RAB15 RAB15 DVL1 DVL1 STX1A STX1A RPH3A RPH3A BRAF BRAF ATP2A2 ATP2A2 STXBP3 STXBP3 ENSMMUP00000042210 ENSMMUP00000042210 STXBP5L STXBP5L HYAL3 HYAL3 CSPG5 CSPG5 SYT1 SYT1 GATA2 GATA2 P2RY1 P2RY1 SYT8 SYT8 CDK5R2 CDK5R2 CACNA1I CACNA1I VAMP8 VAMP8 SYT15 SYT15 CACNA1G CACNA1G SPHK2 SPHK2 PRKCG PRKCG KIAA0100 KIAA0100 MICAL1 MICAL1 CD177 CD177 CDK5 CDK5 H9H440_MACMU H9H440_MACMU BLK BLK WNT7A WNT7A STXBP5 STXBP5 NOTCH1 NOTCH1 SYT4 SYT4 REST REST GRIN3A GRIN3A GATA1 GATA1 TRPV6 TRPV6 LRRK2 LRRK2 CD84 CD84 C11H12orf4 C11H12orf4 VPS18 VPS18 NRXN3 NRXN3 FER FER PDPK1 PDPK1 F7B371_MACMU F7B371_MACMU SYT13 SYT13 SNX4 SNX4 CHRNA5 CHRNA5 SYT10 SYT10 CACNB4 CACNB4 LAMP1 LAMP1 BCR BCR MAMU-F MAMU-F P2RX1 P2RX1 BACE1 BACE1 CACNB2 CACNB2 SLC4A8 SLC4A8 KCNB1 KCNB1 GIPC1 GIPC1 DOC2B DOC2B NLGN1 NLGN1 CNR2 CNR2 IL4 IL4 IL13 IL13 UNC13D UNC13D
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (490 aa)
SYT9Synaptotagmin-9. (491 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (322 aa)
IL13RA2Interleukin 13 receptor subunit alpha 2. (388 aa)
GIPC2PDZ domain-containing protein. (319 aa)
LOC114675624Uncharacterized protein; Belongs to the MAGUK family. (450 aa)
SYT12Synaptotagmin 12. (436 aa)
NCKAP1LNCK associated protein 1 like. (1134 aa)
PREPLUncharacterized protein. (727 aa)
PFN1Profilin; Belongs to the profilin family. (140 aa)
SYNPRSynaptoporin isoform 1. (285 aa)
DTNBP1Dystrobrevin binding protein 1. (425 aa)
PRAM1PML-RARA regulated adaptor molecule 1. (736 aa)
ITGB2Integrin beta. (911 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
RAB27AUncharacterized protein. (321 aa)
FBXL20F-box and leucine rich repeat protein 20. (448 aa)
RIMS3Regulating synaptic membrane exocytosis protein 3. (308 aa)
PLA2G3Phospholipase A2 group III. (509 aa)
GIPC3PDZ domain-containing protein. (1440 aa)
SYN1Synapsin-1 isoform Ia. (705 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
CNR1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP (By similarity). In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. In [...] (472 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
LOC721699Uncharacterized protein. (387 aa)
IL4RInterleukin 4 receptor. (825 aa)
PFN2Profilin; Belongs to the profilin family. (412 aa)
DOC2ADouble C2 domain alpha. (498 aa)
SYT3Synaptotagmin-3. (590 aa)
FGRTyrosine-protein kinase. (529 aa)
SYPSynaptophysin. (401 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (492 aa)
SYT2Synaptotagmin 2. (470 aa)
RAB3D-2Ras-related protein Rab-3D. (219 aa)
SYKTyrosine-protein kinase. (635 aa)
FOXF1Forkhead box F1. (432 aa)
CEACAM1Uncharacterized protein. (525 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (331 aa)
RIMS4Regulating synaptic membrane exocytosis protein 4 isoform 2. (269 aa)
GSK3BGlycogen synthase kinase-3 beta isoform 1; Belongs to the protein kinase superfamily. (433 aa)
GAB2GRB2 associated binding protein 2. (677 aa)
CD160CD160 molecule. (229 aa)
FMR1Fragile X mental retardation 1 protein isoform ISO1. (632 aa)
STXBP2Syntaxin binding protein 2; Belongs to the STXBP/unc-18/SEC1 family. (640 aa)
ENSMMUP00000057803MHC_I-like_Ag-recog domain-containing protein. (216 aa)
GIT1GIT ArfGAP 1. (794 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2352 aa)
SYT6Synaptotagmin 6. (633 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
ADRA1AAdrenoceptor alpha 1A. (445 aa)
SYT11Synaptotagmin-11. (431 aa)
APBA1Amyloid beta precursor protein binding family A member 1. (838 aa)
RPH3ALRabphilin 3A like (without C2 domains). (321 aa)
CBARPCACN subunit beta associated regulatory protein. (752 aa)
LYNTyrosine-protein kinase. (577 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1271 aa)
SYT7Synaptotagmin 7. (708 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (926 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (989 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
KLRC2NKG2-C type II integral membrane protein; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. (415 aa)
SYT5Synaptotagmin 5. (386 aa)
RABGEF1Uncharacterized protein. (492 aa)
DGKIDiacylglycerol kinase. (1100 aa)
RAB15RAB15, member RAS oncogene family. (225 aa)
DVL1Dishevelled segment polarity protein 1. (695 aa)
STX1ASyntaxin-1A isoform 1; Belongs to the syntaxin family. (288 aa)
RPH3ARabphilin 3A. (694 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1011 aa)
STXBP3Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
ENSMMUP00000042210Profilin; Belongs to the profilin family. (186 aa)
STXBP5LSyntaxin binding protein 5 like. (1200 aa)
HYAL3Hyaluronidase-3; Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Belongs to the glycosyl hydrolase 56 family. (417 aa)
CSPG5Chondroitin sulfate proteoglycan 5. (562 aa)
SYT1Synaptotagmin 1. (422 aa)
GATA2GATA binding protein 2. (480 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
SYT8Synaptotagmin 8. (476 aa)
CDK5R2Cyclin-dependent kinase 5 activator. (367 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2111 aa)
VAMP8Vesicle-associated membrane protein 8. (100 aa)
SYT15Uncharacterized protein. (422 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2377 aa)
SPHK2DAGKc domain-containing protein. (669 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (744 aa)
KIAA0100KIAA0100. (2235 aa)
MICAL1Microtubule associated monooxygenase, calponin and LIM domain containing 1. (1069 aa)
CD177CD177 molecule. (424 aa)
CDK5Cyclin dependent kinase 5. (364 aa)
H9H440_MACMUMHC_I-like_Ag-recog domain-containing protein. (128 aa)
BLKTyrosine-protein kinase. (568 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
STXBP5Syntaxin binding protein 5. (1152 aa)
NOTCH1Notch receptor 1. (2556 aa)
SYT4Synaptotagmin IV. (425 aa)
RESTRE1 silencing transcription factor. (1095 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1115 aa)
GATA1GATA binding protein 1. (413 aa)
TRPV6Transient receptor potential cation channel subfamily V member 6; Belongs to the transient receptor (TC 1.A.4) family. (821 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
CD84CD84 molecule. (345 aa)
C11H12orf4Chromosome 11 C12orf4 homolog. (577 aa)
VPS18Vacuolar protein sorting-associated protein 18-like protein. (973 aa)
NRXN3Neurexin 3. (1571 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (557 aa)
F7B371_MACMUProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (313 aa)
SYT13Synaptotagmin-13. (426 aa)
SNX4Sorting nexin 4. (450 aa)
CHRNA5Cholinergic receptor nicotinic alpha 5 subunit. (468 aa)
SYT10Synaptotagmin 10. (523 aa)
CACNB4SH3 domain-containing protein. (520 aa)
LAMP1Lysosomal associated membrane protein 1. (733 aa)
BCRBCR activator of RhoGEF and GTPase. (1271 aa)
MAMU-FMamu class I histocompatibility antigen, alpha chain F; Involved in the presentation of foreign antigens to the immune system. (348 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
BACE1Beta-secretase 1 isoform A preproprotein; Belongs to the peptidase A1 family. (501 aa)
CACNB2SH3 domain-containing protein. (660 aa)
SLC4A8Anion exchange protein. (1093 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
GIPC1PDZ domain-containing protein GIPC1 isoform 1. (333 aa)
DOC2BDouble C2-like domain-containing protein. (408 aa)
NLGN1Neuroligin-1. (823 aa)
CNR2Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family. (360 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (153 aa)
IL13Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. (146 aa)
UNC13DUnc-13 homolog D. (1090 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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