(69 nodes) Negative regulation of G1/S transition of mitotic cell cycle network (Macaca mulatta)

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Your Input:
	BCL2	BCL2 apoptosis regulator. (241 aa)
	MUC1	Mucin 1, cell surface associated. (483 aa)
	RB1	Retinoblastoma-associated protein. (928 aa)
	TREX1	Three prime repair exonuclease 1. (474 aa)
	RBL2	RB transcriptional corepressor like 2. (1141 aa)
	PRAP1	Uncharacterized protein. (149 aa)
	KANK2	KN motif and ankyrin repeat domains 2. (851 aa)
	DLG1	Disks large homolog 1 isoform 2; Belongs to the MAGUK family. (926 aa)
	RBM38	RNA-binding protein 38 isoform a. (237 aa)
	CHEK2	Checkpoint kinase 2. (539 aa)
	RPS27L	40S ribosomal protein S27. (84 aa)
	GJC2	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (441 aa)
	E2F7	E2F transcription factor 7. (910 aa)
	ACVR1	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
	MYO16	Myosin XVI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1876 aa)
	TFDP3	Transcription factor. (406 aa)
	PIDD1	P53-induced death domain protein 1. (913 aa)
	PRMT2	Protein arginine N-methyltransferase 2 isoform 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (433 aa)
	PRKDC	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa)
	RBL1	RB transcriptional corepressor like 1. (1025 aa)
	MDM2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
	GIGYF2	PERQ amino acid-rich with GYF domain-containing protein 2 isoform b. (1302 aa)
	CACNB4	SH3 domain-containing protein. (520 aa)
	CRLF3	Cytokine receptor-like factor 3. (442 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (969 aa)
	WEE1	Wee1-like protein kinase. (646 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa)
	PTEN	Uncharacterized protein. (589 aa)
	RFWD3	Ring finger and WD repeat domain 3. (774 aa)
	WAC	WW domain containing adaptor with coiled-coil. (657 aa)
	FBXO7	F-box only protein 7 isoform 1. (522 aa)
	PLK3	Serine/threonine-protein kinase PLK. (664 aa)
	F6PNW7_MACMU	Uncharacterized protein. (287 aa)
	GFI1B	Growth factor independent 1B transcriptional repressor. (330 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
	BRD7	Bromodomain containing 7. (651 aa)
	NACC2	Nucleus accumbens-associated protein 2. (586 aa)
	DACT1	Dishevelled binding antagonist of beta catenin 1. (837 aa)
	CDKN2B	Cyclin dependent kinase inhibitor 2B. (158 aa)
	JADE1	Uncharacterized protein. (858 aa)
	PML	Promyelocytic leukemia protein. (882 aa)
	CDK2AP2	Cyclin-dependent kinase 2-associated protein; Belongs to the CDK2AP family. (126 aa)
	CCND1	Uncharacterized protein; Belongs to the cyclin family. (303 aa)
	ZC3H12D	Zinc finger CCCH-type containing 12D. (526 aa)
	GPNMB	PKD domain-containing protein. (556 aa)
	TRIAP1	TP53-regulated inhibitor of apoptosis 1. (76 aa)
	CDKN1A	Cyclin-dependent kinase inhibitor 1. (164 aa)
	INHBA	Inhibin subunit beta A. (426 aa)
	KLF4	Kruppel like factor 4. (544 aa)
	CTDSP2	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2. (271 aa)
	RPL26	60S ribosomal protein L26. (145 aa)
	CDC73	Parafibromin. (531 aa)
	PLK5	Serine/threonine-protein kinase PLK. (625 aa)
	APC	APC regulator of WNT signaling pathway. (2871 aa)
	DCUN1D3	DCN1-like protein. (304 aa)
	CDKN1B	Cyclin-dependent kinase inhibitor 1B. (198 aa)
	GML	UPAR/Ly6 domain-containing protein. (175 aa)
	ENSMMUP00000064504	CARD domain-containing protein. (199 aa)
	FBXO31	F-box domain-containing protein. (639 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (832 aa)
	ZNF655	Uncharacterized protein. (597 aa)
	CTDSPL	CTD small phosphatase like. (339 aa)
	DGKZ	Diacylglycerol kinase. (1118 aa)
	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (579 aa)
	CASP2	Caspase 2; Belongs to the peptidase C14A family. (452 aa)
	FHL1	Four and a half LIM domains 1. (339 aa)
	CRADD	Death domain-containing protein CRADD. (199 aa)
	LOC696134	KOW domain-containing protein. (145 aa)
	SDE2	UPF0667 protein C1orf55. (451 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVR1	INHBA	ENSMMUP00000024342	ENSMMUP00000077039	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Inhibin subunit beta A.	0.656
APC	TFDP3	ENSMMUP00000069798	ENSMMUP00000022809	APC regulator of WNT signaling pathway.	Transcription factor.	0.515
APC	TP53	ENSMMUP00000069798	ENSMMUP00000011334	APC regulator of WNT signaling pathway.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.414
ATM	BCL2	ENSMMUP00000005561	ENSMMUP00000069881	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BCL2 apoptosis regulator.	0.558
ATM	CCND1	ENSMMUP00000005561	ENSMMUP00000080080	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein; Belongs to the cyclin family.	0.460
ATM	CDKN1A	ENSMMUP00000005561	ENSMMUP00000077663	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin-dependent kinase inhibitor 1.	0.488
ATM	CDKN2B	ENSMMUP00000005561	ENSMMUP00000001506	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin dependent kinase inhibitor 2B.	0.447
ATM	CHEK2	ENSMMUP00000005561	ENSMMUP00000037133	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Checkpoint kinase 2.	0.997
ATM	EZH2	ENSMMUP00000005561	ENSMMUP00000060546	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.453
ATM	MDM2	ENSMMUP00000005561	ENSMMUP00000018645	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.936
ATM	PIDD1	ENSMMUP00000005561	ENSMMUP00000021972	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	P53-induced death domain protein 1.	0.684
ATM	PRKDC	ENSMMUP00000005561	ENSMMUP00000020132	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.810
ATM	PTEN	ENSMMUP00000005561	ENSMMUP00000011055	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.662
ATM	TP53	ENSMMUP00000005561	ENSMMUP00000011334	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.999
ATM	WEE1	ENSMMUP00000005561	ENSMMUP00000011479	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Wee1-like protein kinase.	0.596
BCL2	ATM	ENSMMUP00000069881	ENSMMUP00000005561	BCL2 apoptosis regulator.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.558
BCL2	CASP2	ENSMMUP00000069881	ENSMMUP00000054085	BCL2 apoptosis regulator.	Caspase 2; Belongs to the peptidase C14A family.	0.591
BCL2	CCND1	ENSMMUP00000069881	ENSMMUP00000080080	BCL2 apoptosis regulator.	Uncharacterized protein; Belongs to the cyclin family.	0.857
BCL2	CDKN1A	ENSMMUP00000069881	ENSMMUP00000077663	BCL2 apoptosis regulator.	Cyclin-dependent kinase inhibitor 1.	0.551
BCL2	CDKN1B	ENSMMUP00000069881	ENSMMUP00000065552	BCL2 apoptosis regulator.	Cyclin-dependent kinase inhibitor 1B.	0.400