STRINGSTRING
NPPB NPPB EPHA2 EPHA2 ATP2B4 ATP2B4 KLF4 KLF4 KHK KHK PF4 PF4 FOXJ2 FOXJ2 HSPG2 HSPG2 COL4A3 COL4A3 ADGRB2 ADGRB2 SPRED1 SPRED1 ECSCR ECSCR SERPINF1 SERPINF1 HGS HGS HOXA5 HOXA5 SPRY2 SPRY2 WNT4 WNT4 SERPINE1 SERPINE1 DAB2IP DAB2IP ENSMMUP00000066948 ENSMMUP00000066948 TAFA5 TAFA5 THBS2 THBS2 MINAR1 MINAR1 TGFB2 TGFB2 SPARC SPARC VASH1 VASH1 CTNNB1 CTNNB1 GHRL GHRL GDF2 GDF2 EPN1 EPN1 SLC12A2 SLC12A2 CD160 CD160 STAT1 STAT1 TNF TNF AGO1 AGO1 PTPRM PTPRM MECP2 MECP2 KLF2 KLF2 COX16 COX16 PLK2 PLK2 SEMA3E SEMA3E ATF2 ATF2 ALOX5 ALOX5 ROCK1 ROCK1 ADGRB3 ADGRB3 GTF2I GTF2I THBS4 THBS4 NAXE NAXE SARS1 SARS1 KRIT1 KRIT1 FOXO4 FOXO4 AMOT AMOT GADD45A GADD45A ADAMTS9 ADAMTS9 SEMA4A SEMA4A ROCK2 ROCK2 SEMA6A SEMA6A SPINK5 SPINK5 ABCC8 ABCC8 SULF1 SULF1 COL4A2 COL4A2 TBC1D31 TBC1D31 CXCL10 CXCL10 ADGRB1 ADGRB1 GPR4 GPR4 HRG HRG CREB3L1 CREB3L1 STAB1 STAB1 DCN DCN CLDN5 CLDN5 CNMD CNMD ISM1 ISM1 APOH APOH ADAMTS1 ADAMTS1 E2F2 E2F2 HHEX HHEX RGCC RGCC YJEFN3 YJEFN3 TIE1 TIE1 ANGPT2 ANGPT2 PIK3CB PIK3CB TNMD TNMD NPR1 NPR1 FASLG FASLG NF1 NF1 IL17F IL17F TEK TEK THBS1 THBS1 FOXC1 FOXC1 PML PML PDE3B PDE3B ANGPT4 ANGPT4 EPN2 EPN2 NIBAN2 NIBAN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NPPBNatriuretic peptide B. (160 aa)
EPHA2EPH receptor A2. (1033 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
KLF4Kruppel like factor 4. (544 aa)
KHKElastin microfibril interfacer 1. (1016 aa)
PF4C-X-C motif chemokine. (101 aa)
FOXJ2Forkhead box J2. (586 aa)
HSPG2Heparan sulfate proteoglycan 2. (4680 aa)
COL4A3Collagen type IV alpha 3 chain. (1674 aa)
ADGRB2Adhesion G protein-coupled receptor B2; Belongs to the G-protein coupled receptor 2 family. (1629 aa)
SPRED1Sprouty-related, EVH1 domain-containing protein 1. (444 aa)
ECSCRUncharacterized protein. (263 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (418 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (805 aa)
HOXA5Homeobox A5. (381 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (407 aa)
DAB2IPDAB2 interacting protein. (1162 aa)
ENSMMUP00000066948Uncharacterized protein. (180 aa)
TAFA5Uncharacterized protein. (198 aa)
THBS2Thrombospondin 2. (1172 aa)
MINAR1UPF0258 domain-containing protein. (936 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SPARCKazal-like domain-containing protein. (343 aa)
VASH1Uncharacterized protein. (447 aa)
CTNNB1Catenin beta-1. (781 aa)
GHRLGhrelin and obestatin prepropeptide. (222 aa)
GDF2Growth differentiation factor 2. (429 aa)
EPN1Epsin 1. (662 aa)
SLC12A2Solute carrier family 12 member 2. (1210 aa)
CD160CD160 molecule. (229 aa)
STAT1Signal transducer and activator of transcription. (802 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
AGO1Protein argonaute-1; Belongs to the argonaute family. (857 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1465 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
KLF2Kruppel like factor 2. (355 aa)
COX16PDZ domain-containing protein. (182 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
ADGRB3Brain-specific angiogenesis inhibitor 3; Belongs to the G-protein coupled receptor 2 family. (1522 aa)
GTF2IUncharacterized protein. (1082 aa)
THBS4Thrombospondin 4. (987 aa)
NAXENAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (307 aa)
SARS1AA_TRNA_LIGASE_II domain-containing protein. (536 aa)
KRIT1Krev interaction trapped protein 1 isoform 1. (736 aa)
FOXO4Fork head domain transcription factor AFX1. (505 aa)
AMOTAngiomotin. (1099 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform 1. (165 aa)
ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif 9. (1935 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (760 aa)
ROCK2Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1474 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1047 aa)
SPINK5Serine peptidase inhibitor, Kazal type 5. (1087 aa)
ABCC8ATP binding cassette subfamily C member 8. (1581 aa)
SULF1Sulfatase 1. (1120 aa)
COL4A2Collagen type IV alpha 2 chain. (1739 aa)
TBC1D31Uncharacterized protein. (1067 aa)
CXCL10C-X-C motif chemokine 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (98 aa)
ADGRB1Adhesion G protein-coupled receptor B1; Belongs to the G-protein coupled receptor 2 family. (1585 aa)
GPR4G protein-coupled receptor 4; Belongs to the G-protein coupled receptor 1 family. (362 aa)
HRGHistidine rich glycoprotein. (525 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (519 aa)
STAB1Stabilin 1. (2575 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
CNMDLeukocyte cell-derived chemotaxin 1 isoform 1. (334 aa)
ISM1Isthmin 1. (464 aa)
APOHApolipoprotein H. (371 aa)
ADAMTS1A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein. (967 aa)
E2F2E2F transcription factor 2. (437 aa)
HHEXHematopoietically expressed homeobox. (270 aa)
RGCCUncharacterized protein. (162 aa)
YJEFN3YjeF N-terminal domain containing 3. (299 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
ANGPT2Angiopoietin 2. (496 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TNMDTenomodulin. (317 aa)
NPR1Guanylate cyclase. (1061 aa)
FASLGTumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa)
NF1Neurofibromin 1. (2867 aa)
IL17FInterleukin-17F. (163 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
THBS1Thrombospondin 1. (1170 aa)
FOXC1Forkhead box C1. (551 aa)
PMLPromyelocytic leukemia protein. (882 aa)
PDE3BPhosphodiesterase. (1117 aa)
ANGPT4Angiopoietin 4. (503 aa)
EPN2Epsin-2 isoform b. (641 aa)
NIBAN2Niban-like protein 1 isoform 1. (746 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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