STRINGSTRING
SHH SHH DUSP1 DUSP1 TACR3 TACR3 ZP1 ZP1 ASPM ASPM OOEP OOEP EAF2 EAF2 INHBC INHBC MAPK15 MAPK15 YTHDC2 YTHDC2 CDC23 CDC23 ANAPC2 ANAPC2 TACR1 TACR1 ZP4 ZP4 IGF1 IGF1 STRA8 STRA8 TAC3 TAC3 ITGB3 ITGB3 ZP3 ZP3 ACVR1C ACVR1C PRDM9 PRDM9 SPINLW1 SPINLW1 BMP7 BMP7 PLCB1 PLCB1 IQCF1 IQCF1 IQCF5 IQCF5 ANAPC10 ANAPC10 GJA1 GJA1 CCDC87 CCDC87 CCR6 CCR6 BCL2L1 BCL2L1 NOX5 NOX5 AGO2 AGO2 UNC5C UNC5C INTS13 INTS13 C1QBP C1QBP PDE5A PDE5A PHLDA2 PHLDA2 NANOS2 NANOS2 PDE3A PDE3A PLB1 PLB1 SHB SHB CDC25C CDC25C WT1 WT1 FGF9 FGF9 HORMAD1 HORMAD1 OXT OXT FBN2 FBN2 SPATA22 SPATA22 ANKRD31 ANKRD31 AR AR OVOL1 OVOL1 CNTD1 CNTD1 ANAPC11 ANAPC11 SOX3 SOX3 STK4 STK4 NR5A1 NR5A1 GLRA1 GLRA1 TRIP13 TRIP13 METTL3 METTL3 MEIOC MEIOC RAD51AP1 RAD51AP1 MOS MOS TACR2 TACR2 LFNG LFNG SYCP2 SYCP2 NPR2 NPR2 ZP2 ZP2 NOTCH1 NOTCH1 SPINK1 SPINK1 SEMG2 SEMG2 JAG1 JAG1 GPR3 GPR3 CDC27 CDC27 VIP VIP FBXO5 FBXO5 RNASE10 RNASE10 FZR1 FZR1 SRC SRC CDC25A CDC25A PRDX4 PRDX4 PPP2R1A PPP2R1A GCM1 GCM1 STK11 STK11 HPGDS HPGDS YBX3 YBX3 NODAL NODAL SULF1 SULF1 CFAP69 CFAP69 SFRP1 SFRP1 GNRH1 GNRH1 TPPP2 TPPP2 ANAPC4 ANAPC4 UMODL1 UMODL1 CDC16 CDC16 MAEL MAEL ADA ADA AURKA AURKA P2RY1 P2RY1 HYAL3 HYAL3 PAEP PAEP CDC20 CDC20 F6V1S9_MACMU F6V1S9_MACMU TIMP1 TIMP1 TEX101 TEX101 CDC25B CDC25B TCP11 TCP11 PIWIL2 PIWIL2 CFAP206 CFAP206 PSMA8 PSMA8 CITED4 CITED4 ENSMMUP00000044881 ENSMMUP00000044881 RAD1 RAD1 SRY SRY STK3 STK3 CIB1 CIB1 FANCA FANCA RPS6KA2 RPS6KA2 CALR CALR NKX3-1 NKX3-1 TEX11 TEX11 NLRP5 NLRP5 OPRD1 OPRD1 CITED2 CITED2 BHMG1 BHMG1 BNC1 BNC1 LIF LIF ACVR1B ACVR1B KIF9 KIF9 MYH9 MYH9 WEE2 WEE2 CACNA1H CACNA1H HDAC2 HDAC2 PLAT PLAT SYDE1 SYDE1 KIT KIT CTNNB1 CTNNB1 DHX37 DHX37 SNAI1 SNAI1 CDKN1B CDKN1B GPR149 GPR149 PLA2G10 PLA2G10 PRSS37 PRSS37 ASTL ASTL SYCE3 SYCE3 WNT4 WNT4 YTHDF3 YTHDF3 ESR1 ESR1 DDB1 DDB1 EFCAB1 EFCAB1 ANAPC1 ANAPC1 PLA2G2F PLA2G2F PAEP-2 PAEP-2 B4GALT1 B4GALT1 RETN RETN AMH AMH SERPINF1 SERPINF1 LOC693332 LOC693332 ZFPM2 ZFPM2 ANAPC7 ANAPC7 PTGDS PTGDS LHFPL2 LHFPL2 SOX9 SOX9 CCDC36 CCDC36 OVGP1 OVGP1 WNT5A WNT5A TAC1 TAC1 NPPC NPPC HOXD13 HOXD13 SPINK13 SPINK13 FBXO42 FBXO42 SMURF2 SMURF2 INHBA INHBA BMP4 BMP4 MSX1 MSX1 DEFB1 DEFB1 APELA APELA SIRT2 SIRT2 PTGDR2 PTGDR2 PRDM14 PRDM14 INHBB INHBB ENSMMUP00000079229 ENSMMUP00000079229
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
TACR3NK-3 receptor; Belongs to the G-protein coupled receptor 1 family. (463 aa)
ZP1Zona pellucida glycoprotein 1. (640 aa)
ASPMAbnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). (3476 aa)
OOEPOocyte expressed protein. (149 aa)
EAF2EAF domain-containing protein. (261 aa)
INHBCTGF_BETA_2 domain-containing protein. (356 aa)
MAPK15Mitogen-activated protein kinase. (544 aa)
YTHDC2YTH domain containing 2. (1430 aa)
CDC23Cell division cycle protein 23 homolog. (597 aa)
ANAPC2Anaphase-promoting complex subunit 2; Belongs to the cullin family. (822 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
ZP4Zona pellucida glycoprotein 4. (538 aa)
IGF1Insulin like growth factor 1. (208 aa)
STRA8Stimulated by retinoic acid 8. (369 aa)
TAC3Tachykinin 3. (196 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (741 aa)
ZP3ZP domain-containing protein. (424 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
PRDM9Uncharacterized protein. (482 aa)
SPINLW1Eppin; Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility (By similarity). (133 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
IQCF1IQ motif containing F1. (205 aa)
IQCF5Uncharacterized protein. (140 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
CCDC87Coiled-coil domain containing 87. (842 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (379 aa)
BCL2L1Bcl-2-like protein 1 isoform 1. (233 aa)
NOX5NADPH oxidase 5. (737 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (867 aa)
UNC5CUnc-5 netrin receptor C. (931 aa)
INTS13Cell cycle regulator Mat89Bb homolog. (706 aa)
C1QBPComplement C1q binding protein. (281 aa)
PDE5APhosphodiesterase. (875 aa)
PHLDA2Pleckstrin homology like domain family A member 2. (152 aa)
NANOS2Nanos C2HC-type zinc finger 2; Belongs to the nanos family. (138 aa)
PDE3APhosphodiesterase. (1141 aa)
PLB1Phospholipase B1. (1461 aa)
SHBSH2 domain containing adaptor protein B. (509 aa)
CDC25CCell division cycle 25C. (507 aa)
WT1WT1 transcription factor. (517 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
HORMAD1HORMA domain-containing protein. (394 aa)
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
FBN2Fibrillin 2. (2912 aa)
SPATA22Spermatogenesis associated 22. (363 aa)
ANKRD31Ankyrin repeat domain 31. (1875 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (895 aa)
OVOL1Uncharacterized protein. (267 aa)
CNTD1Cyclin N-terminal domain containing 1. (329 aa)
ANAPC11Uncharacterized protein. (192 aa)
SOX3HMG box domain-containing protein. (446 aa)
STK4Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...] (487 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (500 aa)
GLRA1Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (449 aa)
TRIP13Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (432 aa)
METTL3N6-adenosine-methyltransferase 70 kDa subunit; Belongs to the MT-A70-like family. (580 aa)
MEIOCMeiosis specific with coiled-coil domain. (955 aa)
RAD51AP1RAD51 associated protein 1. (352 aa)
MOSProto-oncogene serine/threonine-protein kinase mos; Belongs to the protein kinase superfamily. (346 aa)
TACR2Tachykinin receptor 2; Belongs to the G-protein coupled receptor 1 family. (398 aa)
LFNGBeta-1,3-N-acetylglucosaminyltransferase. (379 aa)
SYCP2Synaptonemal complex protein 2. (1530 aa)
NPR2Guanylate cyclase. (1047 aa)
ZP2Zona pellucida glycoprotein 2. (745 aa)
NOTCH1Notch receptor 1. (2556 aa)
SPINK1Serine peptidase inhibitor, Kazal type 1. (79 aa)
SEMG2Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa. (623 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
GPR3G protein-coupled receptor 3; Belongs to the G-protein coupled receptor 1 family. (330 aa)
CDC27Cell division cycle protein 27 homolog isoform 1. (830 aa)
VIPVIP peptides isoform 1 preproprotein. (170 aa)
FBXO5F-box protein 5. (448 aa)
RNASE10Ribonuclease A family member 10 (inactive); Belongs to the pancreatic ribonuclease family. (270 aa)
FZR1Fizzy and cell division cycle 20 related 1. (493 aa)
SRCTyrosine-protein kinase. (644 aa)
CDC25AM-phase inducer phosphatase 1 isoform a. (524 aa)
PRDX4Peroxiredoxin 4. (281 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
GCM1Glial cells missing transcription factor 1. (436 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (433 aa)
HPGDSHematopoietic prostaglandin D synthase; Belongs to the GST superfamily. (199 aa)
YBX3Y-box binding protein 3. (372 aa)
NODALNodal growth differentiation factor. (347 aa)
SULF1Sulfatase 1. (1120 aa)
CFAP69Cilia and flagella associated protein 69. (977 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
GNRH1GnRH-associated peptide 1; Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones; Belongs to the GnRH family. (96 aa)
TPPP2Uncharacterized protein. (170 aa)
ANAPC4Anaphase promoting complex subunit 4. (981 aa)
UMODL1Uromodulin like 1. (852 aa)
CDC16Cell division cycle protein 16 homolog. (620 aa)
MAELProtein maelstrom homolog. (434 aa)
ADAAdenosine deaminase. (390 aa)
AURKASerine/threonine-protein kinase 6; Belongs to the protein kinase superfamily. (403 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
HYAL3Hyaluronidase-3; Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Belongs to the glycosyl hydrolase 56 family. (417 aa)
PAEPLipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (186 aa)
CDC20Cell division cycle protein 20 homolog. (499 aa)
F6V1S9_MACMUUncharacterized protein. (337 aa)
TIMP1Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). (207 aa)
TEX101Testis expressed 101. (258 aa)
CDC25BCell division cycle 25B. (570 aa)
TCP11T-complex 11. (581 aa)
PIWIL2Piwi like-2 protein; Belongs to the argonaute family. (973 aa)
CFAP206Uncharacterized protein. (703 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
CITED4Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4. (232 aa)
ENSMMUP00000044881A_deaminase domain-containing protein. (74 aa)
RAD1Uncharacterized protein. (282 aa)
SRYSex-determining region Y protein; Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involv [...] (203 aa)
STK3Uncharacterized protein. (519 aa)
CIB1Calcium and integrin-binding protein 1. (191 aa)
FANCAFA complementation group A. (1462 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
CALRCalreticulin. (417 aa)
NKX3-1Homeobox protein Nkx-3.1. (232 aa)
TEX11Testis expressed 11. (940 aa)
NLRP5NLR family pyrin domain containing 5. (1173 aa)
OPRD1YTH N6-methyladenosine RNA binding protein 2. (589 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
BHMG1Basic helix-loop-helix and HMG-box containing 1. (642 aa)
BNC1Basonuclin 1. (994 aa)
LIFLIF interleukin 6 family cytokine. (206 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
KIF9Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (715 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1981 aa)
WEE2Wee1-like protein kinase. (568 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2352 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (562 aa)
SYDE1Synapse defective Rho GTPase homolog 1. (733 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
CTNNB1Catenin beta-1. (781 aa)
DHX37DEAH-box helicase 37. (1210 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
GPR149G protein-coupled receptor 149. (731 aa)
PLA2G10Phospholipase A(2). (165 aa)
PRSS37Peptidase S1 domain-containing protein. (234 aa)
ASTLMetalloendopeptidase. (431 aa)
SYCE3Synaptonemal complex central element protein 3. (88 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
YTHDF3YTH N6-methyladenosine RNA binding protein 3. (588 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
EFCAB1EF-hand calcium-binding domain-containing protein 1. (211 aa)
ANAPC1Anaphase promoting complex subunit 1. (2016 aa)
PLA2G2FPhospholipase A(2). (269 aa)
PAEP-2Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (219 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (398 aa)
RETNUncharacterized protein. (248 aa)
AMHAnti-Mullerian hormone. (561 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (418 aa)
LOC693332Uncharacterized protein. (201 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1177 aa)
ANAPC7Anaphase promoting complex subunit 7. (599 aa)
PTGDSProstaglandin-H2 D-isomerase; Belongs to the calycin superfamily. Lipocalin family. (190 aa)
LHFPL2Lipoma HMGIC fusion partner-like 2 protein. (228 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
CCDC36Coiled-coil domain containing 36. (597 aa)
OVGP1Glyco_18 domain-containing protein; Belongs to the glycosyl hydrolase 18 family. (662 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (462 aa)
TAC1Tachykinin precursor 1. (246 aa)
NPPCC-type natriuretic peptide. (126 aa)
HOXD13Homeobox D13. (343 aa)
SPINK13Epididymis-specific trypsin inhibitor-like protein. (94 aa)
FBXO42F-box only protein 42. (716 aa)
SMURF2E3 ubiquitin-protein ligase. (748 aa)
INHBAInhibin subunit beta A. (426 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
DEFB1Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. (68 aa)
APELAUncharacterized protein. (54 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
PTGDR2Prostaglandin D2 receptor 2; Belongs to the G-protein coupled receptor 1 family. (396 aa)
PRDM14PR domain-containing protein 14. (571 aa)
INHBBInhibin subunit beta B. (407 aa)
ENSMMUP00000079229Uncharacterized protein. (756 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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