(64 nodes) Negative regulation of reproductive process network (Macaca mulatta)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	ZFPM2	Zinc finger protein, FOG family member 2. (1177 aa)
	ZP1	Zona pellucida glycoprotein 1. (640 aa)
	EAF2	EAF domain-containing protein. (261 aa)
	ZP4	Zona pellucida glycoprotein 4. (538 aa)
	IGF1	Insulin like growth factor 1. (208 aa)
	ACVR1C	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
	SPINLW1	Eppin; Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility (By similarity). (133 aa)
	BMP7	Bone morphogenetic protein 7. (431 aa)
	GJA1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
	BCL2L1	Bcl-2-like protein 1 isoform 1. (233 aa)
	NANOS2	Nanos C2HC-type zinc finger 2; Belongs to the nanos family. (138 aa)
	SHB	SH2 domain containing adaptor protein B. (509 aa)
	WT1	WT1 transcription factor. (517 aa)
	HORMAD1	HORMA domain-containing protein. (394 aa)
	OVOL1	Uncharacterized protein. (267 aa)
	NR5A1	Nuclear receptor subfamily 5 group A member 1. (500 aa)
	TRIP13	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (432 aa)
	DUSP1	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
	ENSMMUP00000079229	Uncharacterized protein. (756 aa)
	PTGDR2	Prostaglandin D2 receptor 2; Belongs to the G-protein coupled receptor 1 family. (396 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	MOS	Proto-oncogene serine/threonine-protein kinase mos; Belongs to the protein kinase superfamily. (346 aa)
	SYCP2	Synaptonemal complex protein 2. (1530 aa)
	NPR2	Guanylate cyclase. (1047 aa)
	ZP2	Zona pellucida glycoprotein 2. (745 aa)
	SEMG2	Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa. (623 aa)
	FBXO5	F-box protein 5. (448 aa)
	PRDX4	Peroxiredoxin 4. (281 aa)
	STK11	Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (433 aa)
	HPGDS	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. (199 aa)
	YBX3	Y-box binding protein 3. (372 aa)
	NODAL	Nodal growth differentiation factor. (347 aa)
	SULF1	Sulfatase 1. (1120 aa)
	MAEL	Protein maelstrom homolog. (434 aa)
	SPINK13	Epididymis-specific trypsin inhibitor-like protein. (94 aa)
	NPPC	C-type natriuretic peptide. (126 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (462 aa)
	OVGP1	Glyco_18 domain-containing protein; Belongs to the glycosyl hydrolase 18 family. (662 aa)
	ADA	Adenosine deaminase. (390 aa)
	HYAL3	Hyaluronidase-3; Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Belongs to the glycosyl hydrolase 56 family. (417 aa)
	PAEP	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (186 aa)
	TIMP1	Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). (207 aa)
	ENSMMUP00000044881	A_deaminase domain-containing protein. (74 aa)
	RAD1	Uncharacterized protein. (282 aa)
	RPS6KA2	Ribosomal protein S6 kinase. (758 aa)
	CALR	Calreticulin. (417 aa)
	NKX3-1	Homeobox protein Nkx-3.1. (232 aa)
	TEX11	Testis expressed 11. (940 aa)
	NLRP5	NLR family pyrin domain containing 5. (1173 aa)
	LIF	LIF interleukin 6 family cytokine. (206 aa)
	MYH9	Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1981 aa)
	WEE2	Wee1-like protein kinase. (568 aa)
	PLAT	Plasminogen activator; Belongs to the peptidase S1 family. (562 aa)
	KIT	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
	SNAI1	Snail family transcriptional repressor 1. (264 aa)
	CDKN1B	Cyclin-dependent kinase inhibitor 1B. (198 aa)
	GPR149	G protein-coupled receptor 149. (731 aa)
	ASTL	Metalloendopeptidase. (431 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	DDB1	Damage specific DNA binding protein 1. (1147 aa)
	PAEP-2	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (219 aa)
	AMH	Anti-Mullerian hormone. (561 aa)
	SERPINF1	Serpin family F member 1; Belongs to the serpin family. (418 aa)
	PTGDS	Prostaglandin-H2 D-isomerase; Belongs to the calycin superfamily. Lipocalin family. (190 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVR1C	BMP4	ENSMMUP00000004947	ENSMMUP00000077296	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Bone morphogenetic protein 4.	0.684
ACVR1C	BMP7	ENSMMUP00000004947	ENSMMUP00000005446	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Bone morphogenetic protein 7.	0.414
ACVR1C	NODAL	ENSMMUP00000004947	ENSMMUP00000030497	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Nodal growth differentiation factor.	0.957
AMH	IGF1	ENSMMUP00000071412	ENSMMUP00000002988	Anti-Mullerian hormone.	Insulin like growth factor 1.	0.510
AMH	NANOS2	ENSMMUP00000071412	ENSMMUP00000010613	Anti-Mullerian hormone.	Nanos C2HC-type zinc finger 2; Belongs to the nanos family.	0.424
AMH	NR5A1	ENSMMUP00000071412	ENSMMUP00000018545	Anti-Mullerian hormone.	Nuclear receptor subfamily 5 group A member 1.	0.740
AMH	WNT4	ENSMMUP00000071412	ENSMMUP00000068014	Anti-Mullerian hormone.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.555
AMH	WT1	ENSMMUP00000071412	ENSMMUP00000012938	Anti-Mullerian hormone.	WT1 transcription factor.	0.569
ASTL	TEX11	ENSMMUP00000066812	ENSMMUP00000049134	Metalloendopeptidase.	Testis expressed 11.	0.419
ASTL	ZP2	ENSMMUP00000066812	ENSMMUP00000022033	Metalloendopeptidase.	Zona pellucida glycoprotein 2.	0.402
BCL2L1	CDKN1B	ENSMMUP00000007865	ENSMMUP00000065552	Bcl-2-like protein 1 isoform 1.	Cyclin-dependent kinase inhibitor 1B.	0.536
BMP4	ACVR1C	ENSMMUP00000077296	ENSMMUP00000004947	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.684
BMP4	BMP7	ENSMMUP00000077296	ENSMMUP00000005446	Bone morphogenetic protein 4.	Bone morphogenetic protein 7.	0.807
BMP4	IGF1	ENSMMUP00000077296	ENSMMUP00000002988	Bone morphogenetic protein 4.	Insulin like growth factor 1.	0.454
BMP4	LIF	ENSMMUP00000077296	ENSMMUP00000052203	Bone morphogenetic protein 4.	LIF interleukin 6 family cytokine.	0.605
BMP4	WNT5A	ENSMMUP00000077296	ENSMMUP00000074193	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.510
BMP7	ACVR1C	ENSMMUP00000005446	ENSMMUP00000004947	Bone morphogenetic protein 7.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.414
BMP7	BMP4	ENSMMUP00000005446	ENSMMUP00000077296	Bone morphogenetic protein 7.	Bone morphogenetic protein 4.	0.807
BMP7	IGF1	ENSMMUP00000005446	ENSMMUP00000002988	Bone morphogenetic protein 7.	Insulin like growth factor 1.	0.522
BMP7	WNT4	ENSMMUP00000005446	ENSMMUP00000068014	Bone morphogenetic protein 7.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.488