STRINGSTRING
BMP4 BMP4 BMPR1A BMPR1A EGR1 EGR1 KLF4 KLF4 ATOH8 ATOH8 JUN JUN FOS FOS LIN28B LIN28B PDGFB PDGFB BMP2 BMP2 TGFB2 TGFB2 MRTFA MRTFA TNF TNF HIF1A HIF1A RELA RELA FOSL1 FOSL1 SREBF1 SREBF1 TEAD1 TEAD1 MYB MYB SMAD6 SMAD6 STAT3 STAT3 SMAD3 SMAD3 GATA2 GATA2 NFKB1 NFKB1 SRF SRF TGFB1 TGFB1 IL10 IL10 NR1H2 NR1H2 HRAS HRAS ETS1 ETS1 PRL PRL SMAD1 SMAD1 SMAD4 SMAD4 MRTFB MRTFB MYC MYC MYOCD MYOCD GNL3 GNL3 SMARCA4 SMARCA4 TERT TERT ZC3H12A ZC3H12A WT1 WT1 TP53 TP53 PNPT1 PNPT1 GATA3 GATA3 ZSWIM8 ZSWIM8 SREBF2 SREBF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP4Bone morphogenetic protein 4. (408 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (545 aa)
KLF4Kruppel like factor 4. (544 aa)
ATOH8Atonal bHLH transcription factor 8. (357 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (334 aa)
FOSV-fos FBJ murine osteosarcoma viral oncogene-like protein. (380 aa)
LIN28BLin-28 homolog B. (262 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (265 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
MRTFAMyocardin related transcription factor A. (1083 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (826 aa)
RELARELA proto-oncogene, NF-kB subunit. (544 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1177 aa)
TEAD1TEA domain transcription factor 1. (641 aa)
MYBMYB proto-oncogene, transcription factor. (761 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
STAT3Signal transducer and activator of transcription. (871 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
GATA2GATA binding protein 2. (480 aa)
NFKB1Uncharacterized protein. (977 aa)
SRFSerum response factor. (508 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (461 aa)
HRASTransforming protein p21. (189 aa)
ETS1ETS proto-oncogene 1, transcription factor. (548 aa)
PRLProlactin; Prolactin acts primarily on the mammary gland by promoting lactation. (228 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
MRTFBMyocardin related transcription factor B. (1135 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (471 aa)
MYOCDMyocardin. (986 aa)
GNL3Guanine nucleotide-binding protein-like 3 isoform 1. (549 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1679 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1130 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (601 aa)
WT1WT1 transcription factor. (517 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1, mitochondrial. (783 aa)
GATA3GATA binding protein 3. (444 aa)
ZSWIM8Zinc finger SWIM-type containing 8. (1842 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1210 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.