(32 nodes) Lateral plasma membrane network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AKAP7	A-kinase anchoring protein 7. (433 aa)
	CLDN3	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
	LEPR	Leptin receptor; Receptor for hormone LEP/leptin (By similarity). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductiv [...] (1163 aa)
	ANK3	Ankyrin 3. (4375 aa)
	ABCC1	ATP binding cassette subfamily C member 1. (1531 aa)
	KCNB1	Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
	KCNQ1	Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (676 aa)
	VANGL1	Vang-like protein. (535 aa)
	ARL2	ADP-ribosylation factor-like protein 2 isoform 1; Belongs to the small GTPase superfamily. Arf family. (184 aa)
	BVES	Blood vessel epicardial substance. (360 aa)
	SLC6A9	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (706 aa)
	SCN5A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2017 aa)
	NKD2	NKD inhibitor of WNT signaling pathway 2. (477 aa)
	VANGL2	Vang-like protein. (521 aa)
	PTPRO	Uncharacterized protein. (1216 aa)
	OMA1	OMA1 zinc metallopeptidase. (555 aa)
	ATP2B1	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1249 aa)
	MARK2	Non-specific serine/threonine protein kinase. (788 aa)
	LIN7B	Lin-7 homolog B, crumbs cell polarity complex component. (309 aa)
	EPCAM	Epithelial cell adhesion molecule; May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity). Belongs to the EPCAM family. (314 aa)
	MYO1C	Myosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1065 aa)
	SLC12A2	Solute carrier family 12 member 2. (1210 aa)
	TBCD	Tubulin folding cofactor D. (1257 aa)
	CORO1C	Coronin; Belongs to the WD repeat coronin family. (527 aa)
	CEACAM1	Uncharacterized protein. (525 aa)
	FAM168B	Protein FAM168B. (195 aa)
	C1QTNF5	C1q and TNF related 5. (392 aa)
	SLC16A3	Solute carrier family 16 member 3. (465 aa)
	MTCL1	Microtubule crosslinking factor 1. (2028 aa)
	RAB13	Uncharacterized protein. (245 aa)
	SLC16A1	Solute carrier family 16 member 1. (499 aa)
	BSG	Uncharacterized protein. (588 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANK3	SCN5A	ENSMMUP00000004790	ENSMMUP00000020800	Ankyrin 3.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.695
ARL2	TBCD	ENSMMUP00000016165	ENSMMUP00000059148	ADP-ribosylation factor-like protein 2 isoform 1; Belongs to the small GTPase superfamily. Arf family.	Tubulin folding cofactor D.	0.934
BSG	SLC16A1	ENSMMUP00000080741	ENSMMUP00000077172	Uncharacterized protein.	Solute carrier family 16 member 1.	0.971
BSG	SLC16A3	ENSMMUP00000080741	ENSMMUP00000071837	Uncharacterized protein.	Solute carrier family 16 member 3.	0.910
KCNQ1	SCN5A	ENSMMUP00000010172	ENSMMUP00000020800	Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.874
KCNQ1	SLC16A1	ENSMMUP00000010172	ENSMMUP00000077172	Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family.	Solute carrier family 16 member 1.	0.651
MARK2	MTCL1	ENSMMUP00000037412	ENSMMUP00000074767	Non-specific serine/threonine protein kinase.	Microtubule crosslinking factor 1.	0.576
MTCL1	MARK2	ENSMMUP00000074767	ENSMMUP00000037412	Microtubule crosslinking factor 1.	Non-specific serine/threonine protein kinase.	0.576
SCN5A	ANK3	ENSMMUP00000020800	ENSMMUP00000004790	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Ankyrin 3.	0.695
SCN5A	KCNQ1	ENSMMUP00000020800	ENSMMUP00000010172	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family.	0.874
SLC16A1	BSG	ENSMMUP00000077172	ENSMMUP00000080741	Solute carrier family 16 member 1.	Uncharacterized protein.	0.971
SLC16A1	KCNQ1	ENSMMUP00000077172	ENSMMUP00000010172	Solute carrier family 16 member 1.	Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family.	0.651
SLC16A3	BSG	ENSMMUP00000071837	ENSMMUP00000080741	Solute carrier family 16 member 3.	Uncharacterized protein.	0.910
TBCD	ARL2	ENSMMUP00000059148	ENSMMUP00000016165	Tubulin folding cofactor D.	ADP-ribosylation factor-like protein 2 isoform 1; Belongs to the small GTPase superfamily. Arf family.	0.934
VANGL1	VANGL2	ENSMMUP00000011750	ENSMMUP00000026708	Vang-like protein.	Vang-like protein.	0.926
VANGL2	VANGL1	ENSMMUP00000026708	ENSMMUP00000011750	Vang-like protein.	Vang-like protein.	0.926