(28 nodes) Growth factor complex network (Macaca mulatta)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	FLT4	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1362 aa)
	IGFALS	Insulin like growth factor binding protein acid labile subunit. (603 aa)
	VEGFD	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (353 aa)
	IGFBP3	Insulin-like growth factor-binding protein 3 isoform b. (291 aa)
	VEGFB	Vascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
	ANGPT2	Angiopoietin 2. (496 aa)
	EGF	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1213 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	IGFBP4	Insulin-like growth factor-binding protein 4. (258 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
	PDGFA	Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (249 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (421 aa)
	IGFBP2	Insulin like growth factor binding protein 2. (325 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (265 aa)
	PECAM1	Platelet and endothelial cell adhesion molecule 1. (834 aa)
	IGFBP5	Insulin-like growth factor-binding protein 5. (272 aa)
	PGF	Placental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
	HIF1A	Hypoxia-inducible factor 1-alpha isoform 1. (826 aa)
	FLT1	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1474 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	IGFBP6	Insulin-like growth factor-binding protein 6. (239 aa)
	FGF22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	IGF2	Insulin like growth factor 2. (244 aa)
	IGFBP1	Uncharacterized protein. (281 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANGPT2	EGF	ENSMMUP00000013262	ENSMMUP00000013132	Angiopoietin 2.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.440
ANGPT2	FGF2	ENSMMUP00000013262	ENSMMUP00000009729	Angiopoietin 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.526
ANGPT2	FLT1	ENSMMUP00000013262	ENSMMUP00000028363	Angiopoietin 2.	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.919
ANGPT2	FLT4	ENSMMUP00000013262	ENSMMUP00000024605	Angiopoietin 2.	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.875
ANGPT2	HIF1A	ENSMMUP00000013262	ENSMMUP00000056541	Angiopoietin 2.	Hypoxia-inducible factor 1-alpha isoform 1.	0.407
ANGPT2	KDR	ENSMMUP00000013262	ENSMMUP00000016642	Angiopoietin 2.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.901
ANGPT2	PDGFB	ENSMMUP00000013262	ENSMMUP00000066316	Angiopoietin 2.	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.624
ANGPT2	PGF	ENSMMUP00000013262	ENSMMUP00000056902	Angiopoietin 2.	Placental growth factor; Belongs to the PDGF/VEGF growth factor family.	0.570
ANGPT2	VEGFB	ENSMMUP00000013262	ENSMMUP00000016994	Angiopoietin 2.	Vascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family.	0.436
ANGPT2	VEGFC	ENSMMUP00000013262	ENSMMUP00000004996	Angiopoietin 2.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.619
ANGPT2	VEGFD	ENSMMUP00000013262	ENSMMUP00000020668	Angiopoietin 2.	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	0.493
EGF	ANGPT2	ENSMMUP00000013132	ENSMMUP00000013262	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Angiopoietin 2.	0.440
EGF	FGF18	ENSMMUP00000013132	ENSMMUP00000025492	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.919
EGF	FGF2	ENSMMUP00000013132	ENSMMUP00000009729	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.921
EGF	FGF20	ENSMMUP00000013132	ENSMMUP00000080647	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.907
EGF	FGF22	ENSMMUP00000013132	ENSMMUP00000074690	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.918
EGF	FGF6	ENSMMUP00000013132	ENSMMUP00000068686	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.923
EGF	FGF7	ENSMMUP00000013132	ENSMMUP00000012883	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.932
EGF	FGF9	ENSMMUP00000013132	ENSMMUP00000012970	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.905
EGF	FLT1	ENSMMUP00000013132	ENSMMUP00000028363	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.795