(12 nodes) Zinc finger, TRAF-type network (Macaca mulatta)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Predicted Interactions

gene neighborhood

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Your Input:
	PDZRN3	PDZ domain containing ring finger 3. (1066 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (513 aa)
	TRAF4	TNF receptor-associated factor. (470 aa)
	TRAF6	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa)
	TRAF7	E3 ubiquitin-protein ligase TRAF7. (670 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
	XAF1	TRAF-type domain-containing protein. (301 aa)
	RNF151	Uncharacterized protein. (245 aa)
	CYHR1	Cysteine and histidine rich 1. (406 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
	FBXO40	F-box protein 40. (737 aa)
	FBXO30	F-box protein 30. (733 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
TRAF2	TRAF3	ENSMMUP00000015133	ENSMMUP00000066374	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.977
TRAF2	TRAF5	ENSMMUP00000015133	ENSMMUP00000038268	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.982
TRAF2	TRAF6	ENSMMUP00000015133	ENSMMUP00000024012	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]	0.989
TRAF2	TRAF7	ENSMMUP00000015133	ENSMMUP00000025265	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	E3 ubiquitin-protein ligase TRAF7.	0.442
TRAF3	TRAF2	ENSMMUP00000066374	ENSMMUP00000015133	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.977
TRAF3	TRAF5	ENSMMUP00000066374	ENSMMUP00000038268	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.977
TRAF3	TRAF6	ENSMMUP00000066374	ENSMMUP00000024012	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]	0.989
TRAF3	TRAF7	ENSMMUP00000066374	ENSMMUP00000025265	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	E3 ubiquitin-protein ligase TRAF7.	0.468
TRAF4	TRAF6	ENSMMUP00000022296	ENSMMUP00000024012	TNF receptor-associated factor.	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]	0.481
TRAF4	TRAF7	ENSMMUP00000022296	ENSMMUP00000025265	TNF receptor-associated factor.	E3 ubiquitin-protein ligase TRAF7.	0.420
TRAF5	TRAF2	ENSMMUP00000038268	ENSMMUP00000015133	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.982
TRAF5	TRAF3	ENSMMUP00000038268	ENSMMUP00000066374	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.977
TRAF5	TRAF6	ENSMMUP00000038268	ENSMMUP00000024012	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]	0.997
TRAF5	TRAF7	ENSMMUP00000038268	ENSMMUP00000025265	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	E3 ubiquitin-protein ligase TRAF7.	0.410
TRAF6	TRAF2	ENSMMUP00000024012	ENSMMUP00000015133	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.989
TRAF6	TRAF3	ENSMMUP00000024012	ENSMMUP00000066374	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.989
TRAF6	TRAF4	ENSMMUP00000024012	ENSMMUP00000022296	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]	TNF receptor-associated factor.	0.481
TRAF6	TRAF5	ENSMMUP00000024012	ENSMMUP00000038268	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.997
TRAF7	TRAF2	ENSMMUP00000025265	ENSMMUP00000015133	E3 ubiquitin-protein ligase TRAF7.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.442
TRAF7	TRAF3	ENSMMUP00000025265	ENSMMUP00000066374	E3 ubiquitin-protein ligase TRAF7.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.468