(35 nodes) Ras guanine-nucleotide exchange factors catalytic domain network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC106995524-2	Ras-GEF domain-containing protein. (553 aa)
	RAPGEF1	Rap guanine nucleotide exchange factor 1. (1297 aa)
	ENSMMUP00000075182	Ras-GEF domain-containing protein. (455 aa)
	LOC710997	Ras-GEF domain-containing protein. (490 aa)
	RASGEF1A	RasGEF domain family member 1A. (548 aa)
	RASGRF2	Ras protein specific guanine nucleotide releasing factor 2. (1237 aa)
	SH2D3C	SH2 domain containing 3C. (860 aa)
	RAPGEF2	Rap guanine nucleotide exchange factor 2. (1701 aa)
	GBGT1	Uncharacterized protein. (1021 aa)
	LOC107000592	Ras-GEF domain-containing protein. (334 aa)
	LOC106995524	Ras-GEF domain-containing protein. (553 aa)
	F6SS94_MACMU	Ras-GEF domain-containing protein. (447 aa)
	RAPGEF5	Rap guanine nucleotide exchange factor 5. (883 aa)
	RGL2	Ral guanine nucleotide dissociation stimulator-like 2. (777 aa)
	RASGRP4	RAS guanyl releasing protein 4. (673 aa)
	RASGRP1	RAS guanyl releasing protein 1. (826 aa)
	RALGPS2	Ral GEF with PH domain and SH3 binding motif 2. (583 aa)
	RGL1	Ral guanine nucleotide dissociation stimulator-like 1. (803 aa)
	BCAR3	BCAR3 adaptor protein, NSP family member. (835 aa)
	RGL3	Ral guanine nucleotide dissociation stimulator like 3. (708 aa)
	SOS2	Uncharacterized protein. (1332 aa)
	RASGEF1B	RasGEF domain family member 1B. (566 aa)
	RAPGEFL1	Rap guanine nucleotide exchange factor like 1. (667 aa)
	RAPGEF4	Rap guanine nucleotide exchange factor 4. (1047 aa)
	RAPGEF3	Rap guanine nucleotide exchange factor 3. (923 aa)
	RASGRP3	Uncharacterized protein. (695 aa)
	FNIP1	Uncharacterized protein. (1651 aa)
	PLCE1	Phosphoinositide phospholipase C. (2317 aa)
	LOC710293	Ras-GEF domain-containing protein. (553 aa)
	RASGRF1	Ras-specific guanine nucleotide-releasing factor 1. (1273 aa)
	RALGPS1	Ral GEF with PH domain and SH3 binding motif 1. (637 aa)
	RASGRP2	RAS guanyl-releasing protein 2. (609 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1345 aa)
	RASGEF1C	RasGEF domain family member 1C. (482 aa)
	LOC710293-2	Ras-GEF domain-containing protein. (370 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FNIP1	RAPGEF2	ENSMMUP00000008110	ENSMMUP00000044151	Uncharacterized protein.	Rap guanine nucleotide exchange factor 2.	0.901
PLCE1	RAPGEFL1	ENSMMUP00000002160	ENSMMUP00000053359	Phosphoinositide phospholipase C.	Rap guanine nucleotide exchange factor like 1.	0.509
RAPGEF2	FNIP1	ENSMMUP00000044151	ENSMMUP00000008110	Rap guanine nucleotide exchange factor 2.	Uncharacterized protein.	0.901
RAPGEF2	RASGRF2	ENSMMUP00000044151	ENSMMUP00000046122	Rap guanine nucleotide exchange factor 2.	Ras protein specific guanine nucleotide releasing factor 2.	0.473
RAPGEF3	RAPGEF4	ENSMMUP00000056387	ENSMMUP00000053645	Rap guanine nucleotide exchange factor 3.	Rap guanine nucleotide exchange factor 4.	0.949
RAPGEF4	RAPGEF3	ENSMMUP00000053645	ENSMMUP00000056387	Rap guanine nucleotide exchange factor 4.	Rap guanine nucleotide exchange factor 3.	0.949
RAPGEF5	RAPGEFL1	ENSMMUP00000035150	ENSMMUP00000053359	Rap guanine nucleotide exchange factor 5.	Rap guanine nucleotide exchange factor like 1.	0.623
RAPGEFL1	PLCE1	ENSMMUP00000053359	ENSMMUP00000002160	Rap guanine nucleotide exchange factor like 1.	Phosphoinositide phospholipase C.	0.509
RAPGEFL1	RAPGEF5	ENSMMUP00000053359	ENSMMUP00000035150	Rap guanine nucleotide exchange factor like 1.	Rap guanine nucleotide exchange factor 5.	0.623
RASGEF1A	RASGRP1	ENSMMUP00000020200	ENSMMUP00000024105	RasGEF domain family member 1A.	RAS guanyl releasing protein 1.	0.448
RASGEF1A	RASGRP2	ENSMMUP00000020200	ENSMMUP00000064748	RasGEF domain family member 1A.	RAS guanyl-releasing protein 2.	0.487
RASGEF1A	RASGRP4	ENSMMUP00000020200	ENSMMUP00000026962	RasGEF domain family member 1A.	RAS guanyl releasing protein 4.	0.548
RASGEF1A	SOS1	ENSMMUP00000020200	ENSMMUP00000066881	RasGEF domain family member 1A.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.456
RASGRF1	RASGRF2	ENSMMUP00000061619	ENSMMUP00000046122	Ras-specific guanine nucleotide-releasing factor 1.	Ras protein specific guanine nucleotide releasing factor 2.	0.954
RASGRF2	RAPGEF2	ENSMMUP00000046122	ENSMMUP00000044151	Ras protein specific guanine nucleotide releasing factor 2.	Rap guanine nucleotide exchange factor 2.	0.473
RASGRF2	RASGRF1	ENSMMUP00000046122	ENSMMUP00000061619	Ras protein specific guanine nucleotide releasing factor 2.	Ras-specific guanine nucleotide-releasing factor 1.	0.954
RASGRP1	RASGEF1A	ENSMMUP00000024105	ENSMMUP00000020200	RAS guanyl releasing protein 1.	RasGEF domain family member 1A.	0.448
RASGRP1	RASGRP2	ENSMMUP00000024105	ENSMMUP00000064748	RAS guanyl releasing protein 1.	RAS guanyl-releasing protein 2.	0.919
RASGRP1	RASGRP3	ENSMMUP00000024105	ENSMMUP00000057097	RAS guanyl releasing protein 1.	Uncharacterized protein.	0.513
RASGRP1	SOS1	ENSMMUP00000024105	ENSMMUP00000066881	RAS guanyl releasing protein 1.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.924