(105 nodes) Helix-loop-helix DNA-binding domain superfamily network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NPAS2	Neuronal PAS domain-containing protein 2. (824 aa)
	NEUROG3	Neurogenin 3. (215 aa)
	NEUROD1	Neurogenic differentiation factor. (356 aa)
	TCFL5	Transcription factor like 5. (501 aa)
	MSGN1	Mesogenin 1. (193 aa)
	MYOD1	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
	ASCL1	Achaete-scute family bHLH transcription factor 1. (238 aa)
	NEUROG1	Neurogenin 1. (237 aa)
	ID1	DNA-binding protein inhibitor ID-1 isoform a. (154 aa)
	MAX	MYC associated factor X. (160 aa)
	TCF12	Transcription factor 12 isoform a. (706 aa)
	SREBF2	Sterol regulatory element binding transcription factor 2. (1210 aa)
	ATOH1	Atonal bHLH transcription factor 1. (354 aa)
	STRA8	Stimulated by retinoic acid 8. (369 aa)
	USF1	Upstream transcription factor 1. (366 aa)
	ASCL3	Achaete-scute family bHLH transcription factor 3. (181 aa)
	CLOCK	Clock circadian regulator. (852 aa)
	ASCL2	Achaete-scute family bHLH transcription factor 2. (193 aa)
	HELT	Uncharacterized protein. (327 aa)
	ARNT2	Aryl hydrocarbon receptor nuclear translocator 2. (711 aa)
	ARNT	Uncharacterized protein. (786 aa)
	HIF3A	Hypoxia inducible factor 3 subunit alpha. (869 aa)
	MYF6	Myogenic factor 6. (242 aa)
	MYF5	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
	NEUROG2	BHLH domain-containing protein. (272 aa)
	MXI1	Max-interacting protein 1 isoform b. (295 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (471 aa)
	ID4	DNA-binding protein inhibitor ID-4. (161 aa)
	NPAS1	Neuronal PAS domain protein 1. (591 aa)
	ATOH7	Atonal bHLH transcription factor 7. (152 aa)
	NCOA2	Nuclear receptor coactivator. (1468 aa)
	ASCL5	Achaete-scute family bHLH transcription factor 5. (206 aa)
	OLIG2	Oligodendrocyte transcription factor 2. (323 aa)
	HES7	Hes family bHLH transcription factor 7. (253 aa)
	FIGLA	Folliculogenesis specific bHLH transcription factor. (219 aa)
	NHLH1	Nescient helix-loop-helix 1. (133 aa)
	SIM1	SIM bHLH transcription factor 1. (766 aa)
	NEUROD6	Neurogenic differentiation factor. (337 aa)
	ARNTL2	Aryl hydrocarbon receptor nuclear translocator like 2. (636 aa)
	MXD3	Max dimerization protein 3 isoform a. (206 aa)
	TFEB	Transcription factor EB. (490 aa)
	MGA	MAX dimerization protein MGA. (3071 aa)
	HAND2	BHLH domain-containing protein. (186 aa)
	MLXIP	MLX interacting protein. (986 aa)
	HES6	Hes family bHLH transcription factor 6. (283 aa)
	TFE3	Transcription factor E3. (575 aa)
	MESP2	Mesoderm posterior bHLH transcription factor 2. (373 aa)
	NPAS3	Neuronal PAS domain protein 3. (979 aa)
	ID2	Inhibitor of DNA binding 2. (203 aa)
	BHLHE22	Basic helix-loop-helix family member e22. (382 aa)
	AHRR	Uncharacterized protein. (697 aa)
	BHMG1	Basic helix-loop-helix and HMG-box containing 1. (642 aa)
	TCF24	Transcription factor 24. (167 aa)
	ID3	Inhibitor of DNA binding 3, HLH protein. (119 aa)
	MLXIPL	MLX interacting protein like. (880 aa)
	BHLHE23	Basic helix-loop-helix family member e23. (241 aa)
	TFEC	Transcription factor EC. (437 aa)
	SCX	Scleraxis bHLH transcription factor. (201 aa)
	SREBF1	Sterol regulatory element binding transcription factor 1. (1177 aa)
	TCF4	Transcription factor 4. (772 aa)
	BHLHE41	Basic helix-loop-helix family member e41. (482 aa)
	EPAS1	Endothelial PAS domain protein 1. (875 aa)
	MXD4	Max dimerization protein 4. (209 aa)
	HEY1	Hairy/enhancer-of-split related with YRPW motif protein 1 isoform a. (304 aa)
	MNT	MAX network transcriptional repressor. (588 aa)
	TFAP4	Transcription factor AP-4. (338 aa)
	MITF	Microphthalmia-associated transcription factor isoform 1. (520 aa)
	HIF1A	Hypoxia-inducible factor 1-alpha isoform 1. (826 aa)
	OLIG3	Oligodendrocyte transcription factor 3. (273 aa)
	SOHLH2	BHLH domain-containing protein. (502 aa)
	NEUROD2	Neurogenic differentiation factor. (382 aa)
	MYCL	MYCL proto-oncogene, bHLH transcription factor. (394 aa)
	HES5	Uncharacterized protein. (166 aa)
	TCF3	Transcription factor 3. (654 aa)
	HEY2	Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
	TCF15	BHLH domain-containing protein. (197 aa)
	MSC	Musculin. (206 aa)
	HES4	Hes family bHLH transcription factor 4. (252 aa)
	MESP1	Mesoderm posterior bHLH transcription factor 1. (272 aa)
	NCOA1	Nuclear receptor coactivator. (1441 aa)
	TCF23	Transcription factor 23. (214 aa)
	ARNTL	Aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a. (626 aa)
	TAL1	BHLH domain-containing protein. (331 aa)
	AHR	Uncharacterized protein. (848 aa)
	HES2	Hes family bHLH transcription factor 2. (258 aa)
	NEUROD4	Neurogenic differentiation factor. (331 aa)
	HEYL	Hes related family bHLH transcription factor with YRPW motif like. (477 aa)
	NHLH2	BHLH domain-containing protein. (135 aa)
	MYOG	Myogenin. (249 aa)
	SIM2	SIM bHLH transcription factor 2. (667 aa)
	PTF1A	Pancreas associated transcription factor 1a. (329 aa)
	ASCL4	Achaete-scute family bHLH transcription factor 4. (173 aa)
	ATOH8	Atonal bHLH transcription factor 8. (357 aa)
	TCF21	Transcription factor 21. (179 aa)
	MYCN	MYCN proto-oncogene, bHLH transcription factor. (555 aa)
	NCOA3	Nuclear receptor coactivator. (1421 aa)
	HES1	Transcription factor HES-1. (280 aa)
	USF3	Upstream transcription factor family member 3. (2245 aa)
	USF2	BHLH domain-containing protein. (903 aa)
	BHLHE40	Uncharacterized protein. (631 aa)
	HES3	Hes family bHLH transcription factor 3. (178 aa)
	HAND1	Heart and neural crest derivatives expressed 1. (215 aa)
	TWIST2	BHLH domain-containing protein. (160 aa)
	MLX	MAX dimerization protein MLX. (298 aa)
	MXD1	Max dimerization protein 1 isoform 1. (221 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHR	ARNT	ENSMMUP00000069878	ENSMMUP00000000731	Uncharacterized protein.	Uncharacterized protein.	0.970
AHR	ARNT2	ENSMMUP00000069878	ENSMMUP00000000734	Uncharacterized protein.	Aryl hydrocarbon receptor nuclear translocator 2.	0.933
AHR	ARNTL	ENSMMUP00000069878	ENSMMUP00000069046	Uncharacterized protein.	Aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a.	0.816
AHR	ARNTL2	ENSMMUP00000069878	ENSMMUP00000030596	Uncharacterized protein.	Aryl hydrocarbon receptor nuclear translocator like 2.	0.816
AHR	CLOCK	ENSMMUP00000069878	ENSMMUP00000002568	Uncharacterized protein.	Clock circadian regulator.	0.617
AHR	NCOA1	ENSMMUP00000069878	ENSMMUP00000068221	Uncharacterized protein.	Nuclear receptor coactivator.	0.616
AHR	NCOA2	ENSMMUP00000069878	ENSMMUP00000021016	Uncharacterized protein.	Nuclear receptor coactivator.	0.616
AHR	NCOA3	ENSMMUP00000069878	ENSMMUP00000078059	Uncharacterized protein.	Nuclear receptor coactivator.	0.616
AHR	NPAS2	ENSMMUP00000069878	ENSMMUP00000012926	Uncharacterized protein.	Neuronal PAS domain-containing protein 2.	0.616
AHRR	ARNT	ENSMMUP00000048989	ENSMMUP00000000731	Uncharacterized protein.	Uncharacterized protein.	0.747
AHRR	ARNT2	ENSMMUP00000048989	ENSMMUP00000000734	Uncharacterized protein.	Aryl hydrocarbon receptor nuclear translocator 2.	0.747
AHRR	ARNTL	ENSMMUP00000048989	ENSMMUP00000069046	Uncharacterized protein.	Aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a.	0.622
AHRR	ARNTL2	ENSMMUP00000048989	ENSMMUP00000030596	Uncharacterized protein.	Aryl hydrocarbon receptor nuclear translocator like 2.	0.616
AHRR	CLOCK	ENSMMUP00000048989	ENSMMUP00000002568	Uncharacterized protein.	Clock circadian regulator.	0.616
AHRR	NCOA1	ENSMMUP00000048989	ENSMMUP00000068221	Uncharacterized protein.	Nuclear receptor coactivator.	0.616
AHRR	NCOA2	ENSMMUP00000048989	ENSMMUP00000021016	Uncharacterized protein.	Nuclear receptor coactivator.	0.616
AHRR	NCOA3	ENSMMUP00000048989	ENSMMUP00000078059	Uncharacterized protein.	Nuclear receptor coactivator.	0.616
AHRR	NPAS2	ENSMMUP00000048989	ENSMMUP00000012926	Uncharacterized protein.	Neuronal PAS domain-containing protein 2.	0.616
ARNT	AHR	ENSMMUP00000000731	ENSMMUP00000069878	Uncharacterized protein.	Uncharacterized protein.	0.970
ARNT	AHRR	ENSMMUP00000000731	ENSMMUP00000048989	Uncharacterized protein.	Uncharacterized protein.	0.747