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LCP2 LCP2 PLCG1 PLCG1 SH2D7 SH2D7 SHC4 SHC4 ABL1 ABL1 SH2D2A SH2D2A LYN LYN FES FES PTPN11 PTPN11 STAT5A STAT5A GRAP GRAP SHC3 SHC3 TNS2 TNS2 SH2D3C SH2D3C GRB2 GRB2 SLA SLA LCK LCK STAT3 STAT3 CRK CRK BTK BTK ABL2 ABL2 RIN2 RIN2 NCK2 NCK2 CHN2 CHN2 GRB7 GRB7 SH2D4A SH2D4A SHE SHE CHN1 CHN1 ZAP70 ZAP70 SOCS7 SOCS7 SRC SRC GRB10 GRB10 BLK BLK TEC TEC JAK1 JAK1 CLNK CLNK VAV2 VAV2 RIN1 RIN1 BCAR3 BCAR3 GRB14 GRB14 JAK2 JAK2 FER FER PIK3R1 PIK3R1 ITK ITK SOCS1 SOCS1 INPPL1 INPPL1 SH2B2 SH2B2 PTPN6 PTPN6 INPP5D INPP5D TNS4 TNS4 SH2D5 SH2D5 SH2D3A SH2D3A BLNK BLNK SHB SHB SH2D1B SH2D1B SH2D1A SH2D1A SHF SHF SOCS5 SOCS5 FYN FYN MATK MATK SOCS6 SOCS6 FRK FRK SLA2 SLA2 DAPP1 DAPP1 STAP1 STAP1 VAV3 VAV3 CISH CISH CBLC CBLC SHC2 SHC2 SRMS SRMS CBLB CBLB CSK CSK TNS3 TNS3 RINL RINL TYK2 TYK2 GRAP2 GRAP2 SOCS2 SOCS2 SOCS3 SOCS3 STAP2 STAP2 BMX BMX FGR FGR HCK HCK STAT2 STAT2 SH2B3 SH2B3 PIK3R2 PIK3R2 RASA1 RASA1 STAT5B STAT5B YES1 YES1 SUPT6H SUPT6H PLCG2 PLCG2 STAT4 STAT4 PTK6 PTK6 SHC1 SHC1 TNS1 TNS1 NCK1 NCK1 SH2D6 SH2D6 SYK SYK RIN3 RIN3 LOC114669853 LOC114669853 STAT6 STAT6 HSH2D HSH2D PIK3R3 PIK3R3 CBL CBL VAV1 VAV1 STAT1 STAT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LCP2Lymphocyte cytosolic protein 2. (533 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
SH2D7SH2 domain containing 7. (456 aa)
SHC4Src-like proteiny 2 domain-containing-transforming protein C4. (630 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
SH2D2ASH2 domain containing 2A. (399 aa)
LYNTyrosine-protein kinase. (577 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
GRAPUncharacterized protein. (226 aa)
SHC3Uncharacterized protein. (596 aa)
TNS2Tensin 2. (1461 aa)
SH2D3CSH2 domain containing 3C. (860 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
SLASrc like adaptor. (308 aa)
LCKTyrosine-protein kinase. (567 aa)
STAT3Signal transducer and activator of transcription. (871 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
BTKTyrosine-protein kinase. (659 aa)
ABL2Tyrosine-protein kinase. (1182 aa)
RIN2Ras and Rab interactor 2. (981 aa)
NCK2Cytoplasmic protein. (393 aa)
CHN2Chimaerin; GTPase-activating protein for p21-rac. (481 aa)
GRB7Growth factor receptor bound protein 7. (558 aa)
SH2D4ASH2 domain containing 4A. (454 aa)
SHESrc homology 2 domain containing E. (495 aa)
CHN1Chimaerin; GTPase-activating protein for p21-rac. (459 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
SOCS7Suppressor of cytokine signaling 7. (690 aa)
SRCTyrosine-protein kinase. (644 aa)
GRB10Uncharacterized protein. (631 aa)
BLKTyrosine-protein kinase. (568 aa)
TECTyrosine-protein kinase. (685 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
CLNKCytokine dependent hematopoietic cell linker. (443 aa)
VAV2Guanine nucleotide exchange factor VAV2 isoform 1. (878 aa)
RIN1Ras and Rab interactor 1. (783 aa)
BCAR3BCAR3 adaptor protein, NSP family member. (835 aa)
GRB14Growth factor receptor bound protein 14. (540 aa)
JAK2Tyrosine-protein kinase. (1137 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ITKTyrosine-protein kinase. (620 aa)
SOCS1Suppressor of cytokine signaling 1. (215 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1315 aa)
SH2B2SH2B adaptor protein 2. (680 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (626 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1208 aa)
TNS4Tensin 4. (716 aa)
SH2D5Uncharacterized protein. (427 aa)
SH2D3ASH2 domain containing 3A. (605 aa)
BLNKB cell linker. (559 aa)
SHBSH2 domain containing adaptor protein B. (509 aa)
SH2D1BSH2 domain containing 1B. (132 aa)
SH2D1ASH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Ca [...] (130 aa)
SHFSrc homology 2 domain containing F. (488 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
FYNTyrosine-protein kinase. (589 aa)
MATKTyrosine-protein kinase. (773 aa)
SOCS6Suppressor of cytokine signaling 6. (535 aa)
FRKTyrosine-protein kinase. (529 aa)
SLA2Src-like-adapter 2 isoform a. (261 aa)
DAPP1Dual adaptor of phosphotyrosine and 3-phosphoinositides 1. (280 aa)
STAP1Uncharacterized protein. (331 aa)
VAV3Vav guanine nucleotide exchange factor 3. (1128 aa)
CISHCytokine-inducible SH2-containing protein isoform 2. (258 aa)
CBLCCbl proto-oncogene C. (474 aa)
SHC2Uncharacterized protein. (652 aa)
SRMSTyrosine-protein kinase. (489 aa)
CBLBCbl proto-oncogene B. (982 aa)
CSKTyrosine-protein kinase. (450 aa)
TNS3Tensin 3. (1575 aa)
RINLRas and Rab interactor like. (575 aa)
TYK2Tyrosine-protein kinase. (1196 aa)
GRAP2GRB2 related adaptor protein 2. (348 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
STAP2Signal transducing adaptor family member 2. (487 aa)
BMXTyrosine-protein kinase. (683 aa)
FGRTyrosine-protein kinase. (529 aa)
HCKTyrosine-protein kinase. (504 aa)
STAT2Signal transducer and activator of transcription. (851 aa)
SH2B3SH2B adaptor protein 3. (570 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
RASA1RAS p21 protein activator 1. (1044 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
YES1Tyrosine-protein kinase. (543 aa)
SUPT6HTranscription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1726 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
STAT4Signal transducer and activator of transcription. (742 aa)
PTK6Tyrosine-protein kinase. (451 aa)
SHC1SHC-transforming protein 1 isoform 3. (584 aa)
TNS1Tensin 1. (1906 aa)
NCK1Cytoplasmic protein. (377 aa)
SH2D6SH2 domain containing 6. (261 aa)
SYKTyrosine-protein kinase. (635 aa)
RIN3Ras and Rab interactor 3. (982 aa)
LOC114669853Tyrosine-protein kinase. (1125 aa)
STAT6Signal transducer and activator of transcription. (902 aa)
HSH2DHematopoietic SH2 domain containing. (475 aa)
PIK3R3Uncharacterized protein. (507 aa)
CBLE3 ubiquitin-protein ligase CBL. (907 aa)
VAV1Vav guanine nucleotide exchange factor 1. (928 aa)
STAT1Signal transducer and activator of transcription. (802 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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