(15 nodes) Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily network (Macaca mulatta)

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Your Input:
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
	PIK3C2B	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta; Belongs to the PI3/PI4-kinase family. (1634 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	PIK3CG	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1102 aa)
	SMG1	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3660 aa)
	PIK3C2G	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1486 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (908 aa)
	PIK3C2A	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1686 aa)
	PI4KA	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family. (2126 aa)
	PRKDC	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa)
	PI4KB	Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family. (834 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	ATR	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	ATR	ENSMMUP00000005561	ENSMMUP00000010409	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.999
ATM	MTOR	ENSMMUP00000005561	ENSMMUP00000073444	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.540
ATM	PIK3CA	ENSMMUP00000005561	ENSMMUP00000006866	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.475
ATM	PRKDC	ENSMMUP00000005561	ENSMMUP00000020132	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.810
ATM	SMG1	ENSMMUP00000005561	ENSMMUP00000065979	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family.	0.595
ATR	ATM	ENSMMUP00000010409	ENSMMUP00000005561	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.999
ATR	MTOR	ENSMMUP00000010409	ENSMMUP00000073444	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.428
MTOR	ATM	ENSMMUP00000073444	ENSMMUP00000005561	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.540
MTOR	ATR	ENSMMUP00000073444	ENSMMUP00000010409	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.428
MTOR	PIK3CA	ENSMMUP00000073444	ENSMMUP00000006866	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.940
MTOR	PIK3CB	ENSMMUP00000073444	ENSMMUP00000011365	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.934
MTOR	PIK3CD	ENSMMUP00000073444	ENSMMUP00000068489	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.934
MTOR	PIK3CG	ENSMMUP00000073444	ENSMMUP00000066301	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family.	0.523
MTOR	SMG1	ENSMMUP00000073444	ENSMMUP00000065979	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family.	0.553
PI4KA	PI4KB	ENSMMUP00000029182	ENSMMUP00000017300	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family.	0.969
PI4KA	PIK3C2A	ENSMMUP00000029182	ENSMMUP00000029682	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family.	0.907
PI4KA	PIK3C2B	ENSMMUP00000029182	ENSMMUP00000078200	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta; Belongs to the PI3/PI4-kinase family.	0.900
PI4KA	PIK3C2G	ENSMMUP00000029182	ENSMMUP00000065033	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family.	0.922
PI4KA	PIK3C3	ENSMMUP00000029182	ENSMMUP00000046296	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.926
PI4KB	PI4KA	ENSMMUP00000017300	ENSMMUP00000029182	Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.	0.969