node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COQ4 | COQ6 | ENSMMUP00000018589 | ENSMMUP00000014592 | Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family. | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | 0.976 |
COQ4 | ETFDH | ENSMMUP00000018589 | ENSMMUP00000063660 | Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family. | Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. | 0.506 |
COQ6 | COQ4 | ENSMMUP00000014592 | ENSMMUP00000018589 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family. | 0.976 |
COQ6 | ETFDH | ENSMMUP00000014592 | ENSMMUP00000063660 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. | 0.541 |
ETFDH | COQ4 | ENSMMUP00000063660 | ENSMMUP00000018589 | Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. | Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family. | 0.506 |
ETFDH | COQ6 | ENSMMUP00000063660 | ENSMMUP00000014592 | Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | 0.541 |
ETFDH | NDUFS8 | ENSMMUP00000063660 | ENSMMUP00000030525 | Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial. | 0.623 |
ETFDH | SDHB | ENSMMUP00000063660 | ENSMMUP00000002161 | Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). | 0.509 |
NDUFA1 | NDUFA12 | ENSMMUP00000040846 | ENSMMUP00000070899 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1. | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | 0.983 |
NDUFA1 | NDUFA2 | ENSMMUP00000040846 | ENSMMUP00000066684 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1. | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | 0.995 |
NDUFA1 | NDUFA4L2 | ENSMMUP00000040846 | ENSMMUP00000039363 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1. | NADH-ubiquinone oxidoreductase MLRQ subunit-like protein. | 0.765 |
NDUFA1 | NDUFA5 | ENSMMUP00000040846 | ENSMMUP00000063131 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1. | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5. | 0.997 |
NDUFA1 | NDUFAF3 | ENSMMUP00000040846 | ENSMMUP00000065436 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1. | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 isoform a. | 0.694 |
NDUFA1 | NDUFAF4 | ENSMMUP00000040846 | ENSMMUP00000066839 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1. | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4. | 0.731 |
NDUFA1 | NDUFB10 | ENSMMUP00000040846 | ENSMMUP00000063671 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1. | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10. | 0.980 |
NDUFA1 | NDUFB4 | ENSMMUP00000040846 | ENSMMUP00000002128 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1. | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 isoform 2. | 0.991 |
NDUFA1 | NDUFB5 | ENSMMUP00000040846 | ENSMMUP00000012756 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1. | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform 1. | 0.988 |
NDUFA1 | NDUFB7 | ENSMMUP00000040846 | ENSMMUP00000070290 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1. | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7. | 0.979 |
NDUFA1 | NDUFB8 | ENSMMUP00000040846 | ENSMMUP00000035733 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1. | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | 0.916 |
NDUFA1 | NDUFS3 | ENSMMUP00000040846 | ENSMMUP00000005738 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1. | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial; Belongs to the complex I 30 kDa subunit family. | 0.978 |