38 items (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MEIOB	Meiosis specific with OB-fold. (550 aa)
	RPA3	Replication protein A 14 kDa subunit. (121 aa)
	POLE4	DNA polymerase epsilon subunit 4. (117 aa)
	RFC3	Replication factor C subunit 3 isoform 1. (356 aa)
	RFC4	Replication factor C subunit 4. (363 aa)
	RFC2	Replication factor C subunit 2. (233 aa)
	POLE2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
	CUL4B	Cullin 4B; Belongs to the cullin family. (933 aa)
	DTL	Denticleless E3 ubiquitin protein ligase homolog. (730 aa)
	RFC5	Replication factor C subunit 5 isoform 1. (340 aa)
	RPS27A	Uncharacterized protein. (156 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2288 aa)
	RPS27A-2	Ubiquitin-40S ribosomal protein S27a. (156 aa)
	UBA52	Ubiquitin-60S ribosomal protein L40. (128 aa)
	CUL4A	Cullin 4A; Belongs to the cullin family. (759 aa)
	RAD18	RAD18 E3 ubiquitin protein ligase. (505 aa)
	POLD3	DNA polymerase delta subunit 3. (466 aa)
	F7DM39_MACMU	Uncharacterized protein. (143 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	KXD1	KxDL domain-containing protein. (231 aa)
	WDR48	WD repeat domain 48. (745 aa)
	UBC	Uncharacterized protein. (270 aa)
	POLE3	DNA polymerase epsilon subunit 3. (147 aa)
	ATAD5	ATPase family AAA domain containing 5. (1848 aa)
	UBB	Uncharacterized protein. (229 aa)
	RCBTB1	RCC1 and BTB domain-containing protein 1. (531 aa)
	RBX1	E3 ubiquitin-protein ligase RBX1. (108 aa)
	RCBTB2	RCC1 and BTB domain containing protein 2. (556 aa)
	RFC1	Replication factor C subunit 1. (1146 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	ENSMMUP00000067421	Ubiquitin-like domain-containing protein. (135 aa)
	USP1	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (785 aa)
	POLD1	DNA polymerase. (1145 aa)
	ENSMMUP00000069269	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (437 aa)
	DDB1	Damage specific DNA binding protein 1. (1147 aa)
	ENSMMUP00000070235	Ubiquitin-like domain-containing protein. (110 aa)
	POLD2	DNA polymerase delta 2, accessory subunit. (536 aa)
	POLD4	DNA polymerase delta subunit p12. (107 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	CUL4A	ENSMMUP00000050281	ENSMMUP00000025356	ATPase family AAA domain containing 5.	Cullin 4A; Belongs to the cullin family.	0.504
ATAD5	CUL4B	ENSMMUP00000050281	ENSMMUP00000011849	ATPase family AAA domain containing 5.	Cullin 4B; Belongs to the cullin family.	0.504
ATAD5	DDB1	ENSMMUP00000050281	ENSMMUP00000069687	ATPase family AAA domain containing 5.	Damage specific DNA binding protein 1.	0.568
ATAD5	DTL	ENSMMUP00000050281	ENSMMUP00000013304	ATPase family AAA domain containing 5.	Denticleless E3 ubiquitin protein ligase homolog.	0.793
ATAD5	ENSMMUP00000069269	ENSMMUP00000050281	ENSMMUP00000069269	ATPase family AAA domain containing 5.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.677
ATAD5	F7DM39_MACMU	ENSMMUP00000050281	ENSMMUP00000028100	ATPase family AAA domain containing 5.	Uncharacterized protein.	0.463
ATAD5	MEIOB	ENSMMUP00000050281	ENSMMUP00000000992	ATPase family AAA domain containing 5.	Meiosis specific with OB-fold.	0.677
ATAD5	PCNA	ENSMMUP00000050281	ENSMMUP00000062455	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.964
ATAD5	POLD1	ENSMMUP00000050281	ENSMMUP00000068636	ATPase family AAA domain containing 5.	DNA polymerase.	0.778
ATAD5	POLD2	ENSMMUP00000050281	ENSMMUP00000079598	ATPase family AAA domain containing 5.	DNA polymerase delta 2, accessory subunit.	0.656
ATAD5	POLE	ENSMMUP00000050281	ENSMMUP00000020284	ATPase family AAA domain containing 5.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.871
ATAD5	POLE2	ENSMMUP00000050281	ENSMMUP00000005221	ATPase family AAA domain containing 5.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.815
ATAD5	POLE3	ENSMMUP00000050281	ENSMMUP00000049200	ATPase family AAA domain containing 5.	DNA polymerase epsilon subunit 3.	0.746
ATAD5	POLE4	ENSMMUP00000050281	ENSMMUP00000002454	ATPase family AAA domain containing 5.	DNA polymerase epsilon subunit 4.	0.687
ATAD5	RAD18	ENSMMUP00000050281	ENSMMUP00000026314	ATPase family AAA domain containing 5.	RAD18 E3 ubiquitin protein ligase.	0.779
ATAD5	RBX1	ENSMMUP00000050281	ENSMMUP00000056775	ATPase family AAA domain containing 5.	E3 ubiquitin-protein ligase RBX1.	0.424
ATAD5	RFC1	ENSMMUP00000050281	ENSMMUP00000057228	ATPase family AAA domain containing 5.	Replication factor C subunit 1.	0.777
ATAD5	RFC2	ENSMMUP00000050281	ENSMMUP00000005125	ATPase family AAA domain containing 5.	Replication factor C subunit 2.	0.984
ATAD5	RFC3	ENSMMUP00000050281	ENSMMUP00000004492	ATPase family AAA domain containing 5.	Replication factor C subunit 3 isoform 1.	0.978
ATAD5	RFC4	ENSMMUP00000050281	ENSMMUP00000004943	ATPase family AAA domain containing 5.	Replication factor C subunit 4.	0.985